- Lecturer, School of Biological Sciences, UEA (2007-)
- Postdoctoral Fellow, Institute of Food Research, UK (2004-2007)
- MRes & Ph.D. - University of Glasgow, UK (2000-2004)
- B.Sc. – Biomedical Science, University of Bradford, UK (1996-2000)
<- Page 1 of 2 ->
CX3CR1+ Cell–Mediated Salmonella Exclusion Protects the Intestinal Mucosa during the Initial Stage of InfectionFull Text UEA Repository
The metabolic impact of extracellular nitrite on aerobic metabolism ofFull Text UEA Repository
Nitrous Oxide Metabolism in Nitrate-Reducing Bacteria: Physiology and Regulatory MechanismsFull Text UEA Repository
Genome-Wide Discovery of Putative sRNAs in Paracoccus denitrificans Expressed under Nitrous Oxide Emitting ConditionsFull Text UEA Repository
Living with stress: A lesson from the enteric pathogen salmonella entericaFull Text UEA Repository
Copper control of bacterial nitrous oxide emission and its impact on vitamin B12-dependent metabolismFull Text UEA Repository
Resolving the contributions of the membrane-bound and periplasmic nitrate reductase systems to nitric oxide and nitrous oxide production in Salmonella enterica serovar TyphimuriumFull Text UEA Repository
ZraP is a periplasmic molecular chaperone and a repressor of the zinc-responsive two-component regulator ZraSRFull Text UEA Repository
The impact of copper, nitrate and carbon status on the emission of nitrous oxide by two species of bacteria with biochemically distinct denitrification pathwaysFull Text UEA Repository
Nitrous oxide production in soil isolates of nitrate-ammonifying bacteriaFull Text UEA Repository
Chip-seq and transcriptome analysis of the OmpR regulon od Salmonella enterica serovas Typhi and Typhimurium reveals accessory genes implicated in host colonizationFull Text UEA Repository
The production and detoxification of a potent cytotoxin, nitric oxide, by pathogenic enteric bacteriaFull Text UEA Repository
Novel Inducers of the Envelope Stress Response BaeSR in Salmonella Typhimurium: BaeR Is Critically Required for Tungstate Waste DisposalFull Text UEA Repository
The periplasmic chaperone Skp is required for successful Salmonella Typhimurium infection in a murine typhoid modelFull Text UEA Repository
Glucose and glycolysis are required for the successful infection of macrophages and mice by Salmonella enterica serovar typhimuriumFull Text UEA Repository
Salmonella enterican Serovar Typhimurium HtrA: regulation of expression and role of the chaperone and protease activities during infectionFull Text UEA Repository
All Stressed Out. Salmonella Pathogenesis and Reactive Nitrogen SpeciesFull Text UEA Repository
Small outer-membrane lipoprotein, SmpA, is regulated by oE and has a role in cell envelope integrity and virulence of Salmonella enterica serovar TyphimuriumFull Text UEA Repository
A combination of cytochrome c nitrite reductase (NrfA) and flavorubredoxin (NorV) protects Salmonella enterica serovar Typhimurium against killing by NO in anoxic environmentsFull Text UEA Repository
Role of the alternative sigma factors sigmaE and sigmaS in survival of Salmonella enterica serovar Typhimurium during starvation, refrigeration and osmotic shockFull Text UEA Repository
<- Page 1 of 2 ->
Key Research Interests
I am a Molecular Microbiologist and my primary research interests relate to the environmental regulation of enteric pathogens such as Salmonella Typhimurium. We are particular interested in dissecting how various stresses and stimuli impact on virulence phenotypes, and whether they can be manipulated to develop novel antimicrobial or vaccine targets.
Current Research Projects
- Integration of envelope stress response pathways.
- The role of nitric oxide detoxification in physiology and pathogenesis.
- Identification of novel drug transport mechanisms.
- Nitrous oxide production by enteric and environmental bacteria (with Prof David Richardson)
- The role of chaperones in periplasmic homeostasis (with Dr Tom Clarke).
Life in our research group
Our research group uses a powerful combination of genetics, functional genomics, infection models and chemostat culture systems to understand the mechanisms that bacterial pathogens use to cause disease. We use the excellent facilities across the NRP such as the Wolfson Fermentation Laboratory and the brand new tissue culture facilities in the Biomedical research Centre. We are a new lab with lots of European flair and like to keep the fun in our science. We get together on a regular basis for lab meetings and journal presentations and we make sure that at least one group member goes to conferences relevant to our work. Group members recently presented at the American Society for Microbiology Salmonella Conference in Aix en Provence and we always make a regular appearance at Society for General Microbiology meetings in the UK. We are also committed to Science Outreach with lab members taking part in local science activities. We currently collaborate with several groups across the UK. If you think we can collaborate or help you in anyway please contact us.
Postdocs & Fellows
I am always happy to discuss possibilities for postdoctoral work and collaborations. Possible funding routes include applying for fellowships, e.g. EU Marie Curie or Royal Society fellowships, with me acting as sponsor, or grant applications with you as a named postdoc.
- Skills for Biologists (BIO-1A4Y)
- Microbiology (BIO-2B28)
- Molecular Biology (BIO-2B02)
- Molecular Cell Biology (BIO-3C10)
- Microbial Biotechnology (BIO-3C09)
- Infection and Immunity (BIO-3C28)
- Medical Biotechnology (BIO-M105)
- Microbial and Enzyme Biotechnology (BIO-M101)
- Medical Biotechnology and Host:Pathogen Interactions (BIO-M207)
- Research Skills (BIO-M14Y)
- Research project (BIO-M13Y)
External Activities and Indicators of Esteem
- Council member of the Society of General Microbiology (2008-2012).
- Member of the American Society of Microbiology, the European Society of Clinical Microbiology and Infectious Disease and the Institute of Biology.
- Invited Speaker at NO: From Marvel to Menace, EuroSciCon, 2009.
- Director of Postgraduate Teaching (BIO).
- Deputy Director of Teaching (BIO).
- Director of the Wolfson Fermentation Suite.
- Course Director for the MSc in Biotechnology for a Sustainable future.
- Module organiser for Infection and Immunity (BIO-3C28)
- Module organiser for Medical Biotechnology (BIO-M105)
- Module organiser for Medical Biotechnology and Host:Pathogen Interactions (BIO-M207)
- Module organiser for Research Skills (BIO-M14Y)
- Module organiser for Research Project (BIO-M13Y).