Career History

  • Senior Lecturer, University of East Anglia (2014-present)
  • Lecturer, University of East Anglia (2000-present)
  • Post Doctoral Fellow, John Innes Centre (1993-2000)
  • Post Doctoral Fellow, University of Leicester (1991-1993)
  • Leverhulme Trust Fellowship, University of Leicester, Department of Biochemistry (1989-1990)
  • Ph.D. - Eötvös Loránd University Budapest, Hungary (1987)
  • B.Sc. - Chemistry; Eötvös Loránd University Budapest, Hungary (1984)
     

ResearcherID 

http://www.researcherid.com/rid/G-8486-2011


MSc (Master of Science) training by research is available in my laboratory. Please contact me if you are interested. Click here for further details.

All Publications

Kelemen, G. H.

(2017)

Intermediate Filaments Supporting Cell Shape and Growth in Bacteria,

in Prokaryotic Cytoskeletons.

Springer International Publishing

pp. 161-211

ISBN 978-3-319-53045-1

Full Text

(Other chapter contribution)

(Published)


Tzanis, A., Dalton, K. A., Hesketh, A., Den Hengst, C. D., Buttner, M. J., Thibessard, A., Kelemen, G. H.

(2014)

A sporulation specific, sigF -dependent protein, SspA, affects septum positioning in Streptomyces coelicolor,

in Molecular Microbiology

91

(2)

pp. 363-380

Full Text UEA Repository

(Article)

(Published)


Ditkowski, B., Holmes, N., Rydzak, J., Donczew, M., Bezulska, M., Ginda, K., Kedzierski, P., Zakrzewska-Czerwinska, J., Kelemen, G., Jakimowicz, D.

(2013)

Dynamic interplay of ParA with the polarity protein, Scy, coordinates growth with chromosome segregation in Streptomyces coelicolor,

in Open Biology

3

(3)

article no. 130006

Full Text UEA Repository

(Article)

(Published)


Holmes, N., Walshaw, J., Leggett, R., Thibessard, A., Dalton, K., Gillespie, M., Hemmings, A., Gust, B., Kelemen, G.

(2013)

Coiled-coil protein Scy is a key component of a multiprotein assembly contrlling polarized growth in Streptomyces,

in Proceedings of the National Academy of Sciences of the United States of America (PNAS)

110

(5)

pp. 397-406

UEA Repository

(Article)

(Published)


Walshaw, J., Gillespie, M., Kelemen, G.

(2010)

A novel coiled-coil repeat variant in a class of bacterial cytoskeletal proteins,

in Journal of Structural Biology

170

(2)

pp. 202-215

Full Text UEA Repository

(Article)

(Published)


Leggett, R., Grandison, S., Morris, R., Kelemen, G., Moulton, V.

(2009)

Statistical analysis of the growth and morphology of the filamentous microbe Streptomyces coelicolor.,

(Other)

(Published)


Gaskell, A., Crack, J., Cheeseman, M., Kelemen, G., Hutchings, M., Le Brun, N.

(2007)

RsmA, an anti-sigma factor from Streptomyces coelicolor, modulates its activity through a [2Fe-2s] cluster cofactor,

in Journal of Biological Chemistry

282

(43)

pp. 31812-31820

Full Text UEA Repository

(Article)

(Published)


Dalton, K., Thibessard, A., Hunter, J., Kelemen, G.

(2007)

A novel compartment, the 'subqpical stem' of the aerial hyphae, is the location of a sigN-dependent, developmentally distinct transcription in Streptomyces coelicolor.,

in Molecular Microbiology

64

(3)

pp. 719-737

Full Text UEA Repository

(Article)

(Published)


Hunt, A., Servin-Gonzalez, L., Kelemen, G., Buttner, M.

(2005)

The bldC developmental locus of Streptomyces coelicolor encodes a member of a family of small DNA-binding proteins related to the DNA-binding domains of the MerR family.,

in Journal of Bacteriology

187

(2)

pp. 716-728

Full Text UEA Repository

(Article)

(Published)


Traag, B., Kelemen, G., van Wezel, G.

(2004)

Transcription of the sporulation gene ssgA is activated by the IcIR-type regulator SsgR in a whi-independent manner in Streptomyces coelicolor A3(2).,

in Molecular Microbiology

53

(3)

pp. 985-1000

Full Text UEA Repository

(Article)

(Published)


Viollier, P., Kelemen, G., Dale, G., Nguyen, K., Buttner, M., Thompson, C.

(2003)

Specialized osmotic stress response systems involve multiple SigB-like sigma factors in Streptomyces coelicolor.,

in Molecular Microbiology

47

(3)

pp. 699-714

Full Text UEA Repository

(Article)

(Published)


Kelemen, G., Viollier, P., Tenor, J., Marri, L., Buttner, M., Thompson, C.

(2001)

A connection between stress and development in the multicelular prokaryote Streptomyces coelicolor.,

in Molecular Microbiology

40

(4)

pp. 804-814

Full Text UEA Repository

(Article)

(Published)


Key Research Interests

Our main research interest is studying bacterial development of Streptomyces coelicolor, a Gram-positive, filamentous bacterium. Unlike most bacteria that divide by binary fission, in Streptomyces coelicolor long, multigenomic filaments are formed with ocasional septa and regular branching. Cell division is completed only during sporulation when 50-100 sporulation septa are laid down synchronously in the aerial hyphae generating unigenomic spore compartments.

Current Research Projects 

  • Bacterial polarised growth and its control by cytoskeletal proteins
  • Coiled-coil proteins as synthetic scaffolds
  • Chromosome organisation during hyphal growth
  • Signalling in bacterial development
  • The role of specific RNA polymerase holoenzymes controlling development and stress response
  • Global characterisation of spore maturation and germination


MSc (Master of Science) training by research is available in my laboratory. Please arrange a meeting with me if you are interested. Click here for further details. 

Life in our Research Group 

Our laboratory focuses on the biology of the model organism for bacterial development and antibiotic production, Streptomyces coelicolor. This exciting bacterium forms long, multigenomic filaments with complex branching patterns and at the end of its life cycle generates unigenomic spores ready for dispersal. Importantly, streptomycetes are the producers of more than 70% of the commercially available antibiotics. We are studying the mechanism of regulation of the complex developmental cycle of Streptomyces, including studies on gene expression, intra- and intercellular signalling and bacterial cytoskeletal proteins controlling cell shape and cell cycle using molecular biology, biochemistry and cell biology techniques. For localisation studies we access the Henry Wellcome Imaging laboratory for “state of the art” microscopy technologies. We have lab meetings and departmental seminars where we discuss experimental progress and recent publications. To present our results we regularly attend national and international conferences, such as the Society of General Microbiology meetings, the International Symposium on the Biology of Actinomycetes and Meetings on Bacterial Development.

PhD Positions

We are seeking applicants for a PhD Studentship on “Coiled-coil proteins as nano-wire scaffolds”. Please contact me for any further information on this project.

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.


Postdocs & Fellows

I am always happy to discuss possibilities for postdoctoral work and collaborations. Possible funding routes include fellowship appliactions, e.g. EU Marie Curie fellowships, with me acting as sponsor, or grant applications with you as a named postdoc.

Teaching Interests

  • Molecular Biology (2B02 or 5003B)
  • Microbiology (2B28)
  • Microbial Cell Biology (3C10)
  • Mathematics and Statistics for Biologists (4008Y and 4009Y)
  • Fundamentals of Cell Biology and Biochemistry (4003B)

External Activities and Indicators of Esteem

2014 June –  2nd International Workshop on the Biology and Physics of Bacterial Chromosomes, Birmingham UK; Talk: Molecular link between a polarity centre and chromosome organisation in Streptomyces.

2014 September- Meeting for OUC-UEA Strategic Alliance in Integrative Ocean Science, Talk: Polar growth in bacteria – is there a possible link to environmental adaptation?

2014 October – invited speaker at the XVII. International Symposium on the Biology of Actinomycetes ( ISBA'17) in Turkey, Izmir: Molecular link between TIPOC, a polarity centre, and chromosome organisation in Streptomyces.

 

Administrative Posts

  • Director of Prostgraduate Studies in the School of Biological Sciences
  • Course Director for Molecular Biology and Genetics and Genetics
  • Module Organiser for Molecular Biology (2B02 and now 5003B; 2003-present)
  • Member of the Exam Board
  • Deputy Senior Advisor