Biography

Studied Biology at the Ludwig-Maximilians Universität in Munich (Germany) and graduated in 1979 (Diploma, Biology). After civil service, worked on my PhD thesis at the Max-Planck Institute for Biochemistry in Martinsried (Germany) in the department of ‘Connective Tissue Research’ of Prof. K. Kühn. The thesis focused on novel genes expressed in cartilage (Supervisor: Prof. P.K. Müller) and was finished in 1984 (Dr. rer.nat.). During a period as research scientist at the Sandoz Science Institute (Vienna, Austria), worked on immunological aspects of pharmacologically relevant cytokines. Thereafter, joined the group of Prof. K. Kühn at the Max-Planck Institute in Martinried and focused on various aspects of the genetics and biology of collagen IV and other extracellular matrix. In a number of collaborations with Prof. R. Timpl these studies were extended to other proteins, like perlecan, nidogens or laminins. Established a research group in the Department of ‘Experimental Medicine I’ (Director Prof. K. vonderMark) at the ‘Nikolaus-Fiebiger Zentrum’, a research centre of the Medical Faculty of the University of Erlangen-Nürnberg (Erlangen, Germany). Continued with the analysis of ECM proteins, but also started new projects focusing on the protein family of the annexins or human diseases (Osteaoarthritis). During this period, I was teaching mainly at the Medical Faculty where also the degree of  ‘Habilitation’ (Dr. med.habil.; 1997) was received. Joined the School of Biological Sciences at the University of East Anglia in 2005.

Career History

  • 2005-present: Senior Lecturer, University of East Anglia, Norwich, UK
  • 1997-2005:  Privatdozent (apl. Prof.), University of Erlangen-Nürnberg, Germany
  • 1997: Habilitation (Dr.med.habil.) Medical Faculty, University of Erlangen-Nürnberg, Germany
  • 1992-1997: Research Scientist/Group leader, University of Erlangen-Nürnberg, Germany
  • 1986-1992: Research Assistant, Max-Planck Institute of Biochemistry, Martinsried, Germany
  • 1985-1986: Research Scientist, Sandoz-Forschungs-Institut, Wien, Austria
  • 1985: Research Assistant, Max Planck Institute of Biochemistry, Martinsried, Germany
  • 1984: Dr.rer.nat. (PhD): Biology, University of München, Germany
  • 1979: Diploma Biology, University of München, Germany  

All Publications

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Reuten, R., Patel, T. R., Mcdougall, M., Rama, N., Nikodemus, D., Gibert, B., Delcros, J., Prein, C., Meier, M., Metzger, S., Zhou, Z., Kaltenberg, J., Mckee, K. K., Bald, T., Tüting, T., Zigrino, P., Djonov, V., Bloch, W., Clausen-Schaumann, H., Poschl, E., Yurchenco, P. D., Ehrbar, M., Mehlen, P., Stetefeld, J., Koch, M.

(2016)

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes,

in Nature Communications

7

article no. 13515

Full Text UEA Repository

(Article)

(Published)


Zhou, Z., Pausch, F., Schlötzer-Schrehardt, U., Brachvogel, B., Pöschl, E.

(2016)

Induction of initial steps of angiogenic differentiation and maturation of endothelial cells by pericytes in vitro and the role of collagen IV,

in Histochemistry and Cell Biology

145

(5)

pp. 511-525

Full Text UEA Repository

(Article)

(Published)


Pitzler, L., Auler, M., Probst, K., Frie, C., Bergmeier, V., Holzer, T., Belluocio, D., Van der Bergen, J., Etich, J., Ehlen, H., Zhou, Z., Bielke, W., Poschl, E., Paulsson, M., Brachvogel, B.

(2016)

miR-126-3p promotes matrix-dependent perivascular cell attachment, migration and intercellular interaction,

in Stem Cells

34

(5)

pp. 1297-1309

Full Text UEA Repository

(Article)

(Published)


Kreft, S., Klatt, A. R., Strassburger, J., Poschl, E., Flower, R. J., Emig, S., Reutlingsperger, C., Brisson, A., Brachvogel, B.

(2016)

Skin wound repair is not altered in the absence of endogenous AnxA1 or AnxA5, but pharmacological concentrations of AnxA4 and AnxA5 inhibit wound hemostasis,

in Cells Tissues Organs

201

(4)

pp. 287-298

Full Text UEA Repository

(Article)

(Published)


Grskovic, I., Kutsch, A., Frie, C., Groma, G., Stermann, J., Schlötzer-Schrehardt, U., Niehoff, A., Moss, S., Rosenbaum, S., Poschl, E., Chmielewski, M., Rappl, G., Abken, H., Bateman, J., Cheah, K., Paulsson, M., Brachvogel, B.

(2012)

Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response,

in Journal of Bone and Mineral Research

27

(11)

pp. 2399-412

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(Article)

(Published)


Poschl, E.

(2012)

Improved methods for detection of β-galactosidase (lacZ) activity in hard tissue,

in Histochemistry and Cell Biology

137

(6)

pp. 841-847

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(Article)

(Published)


Ueki, H., Mizushina, T., Laoharatchatathanin, T., Terashima, R., Nishimura, Y., Rieanrakwong, D., Yonezawa, T., Kurusu, S., Hasegawa, Y., Brachvogel, B., Poschl, E., Kawaminami, M.

(2012)

Loss of maternal annexin A5 increases the likelihood of placental platelet thrombosis and foetal loss,

in Scientific Reports

2

pp. 827

UEA Repository

(Article)

(Published)


Bouter, A., Gounou, C., Bérat, R., Tan, S., Gallois, B., Granier, T., d'Estaintot, B., Pöschl, E., Brachvogel, B., Brisson, A.

(2011)

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair,

in Nature Communications

2

pp. 274

Full Text UEA Repository

(Article)

(Published)


Rosenbaum, S., Kreft, S., Etich, J., Frie, C., Stermann, J., Grskovic, I., Frey, B., Mielenz, D., Pöschl, E., Gaipl, U., Paulsson, M., Brachvogel, B.

(2011)

Identification of novel binding partners (annexins) for the cell death signal phosphatidylserine and definition of their recognition motif,

in Journal of Biological Chemistry

286

(7)

pp. 5708-16

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(Article)

(Published)


Cooley, L., Handsley, M., Zhou, Z., Lafleur, M., Pennington, C., Thompson, E., Poschl, E., Edwards, D.

(2010)

Reversible trans-differentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro,

in Journal of Cell Science

123

(21)

pp. 3808-3816

Full Text UEA Repository

(Article)

(Published)


Belluoccio, D., Grskovic, I., Niehoff, A., Schlotzer-Schrehardt, U., Rosenbaum, S., Etich, J., Frie, C., Pausch, F., Moss, S., Poschl, E., Bateman, J., Brachvogel, B.

(2009)

Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization,

in Journal of Bone and Mineral Research

25

(1)

pp. 141-153

Full Text UEA Repository

(Article)

(Published)


Frey, B., Munoz, L., Pausch, F., Sieber, R., Franz, S., Brachvogel, B., Poschl, E., Schneider, H., Rodel, F., Sauer, R., Fietkau, R., Herrmann, M., Gaipl, U.

(2008)

The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotype,

in Journal of Cellular and Molecular Medicine

13

(7)

pp. 1391-1399

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(Article)

(Published)


Brachvogel, B., Pausch, F., Farlie, P., Gaipl, U., Etich, J., Zhou, Z., Cameron, T., von der Mark, K., Bateman, J. F., Pöschl, E.

(2007)

Isolated Anxa5(+)/Sca-1(+) perivascular cells from mouse meningeal vasculature retain their perivascular phenotype in vitro and in vivo,

in Experimental Cell Research

313

(12)

pp. 2730-2743

Full Text UEA Repository

(Article)

(Published)


Munoz, L., Frey, B., Pausch, F., Baum, W., Mueller, R., Brachvogel, B., Poschl, E., Rodel, F., von der Mark, K., Herrmann, M., Gaipl, U.

(2007)

The Role of Annexin A5 in the Modulation of the Immune Response Against Dying and Dead Cells,

Full Text UEA Repository

(Working paper)

(Published)


Gaipl, U., Munoz, L., Rodel, F., Pausch, F., Frey, B., Brachvogel, B., von der Mark, K., Poschl, E.

(2007)

Modulation of the immune system by dying clls an the phosphatidylserine-ligand annexin A5,

in Autoimmunity

40

pp. 254-259

Full Text UEA Repository

(Article)

(Published)


Gebhard, S., Hattori, T., Bauer, E., Bosl, M., Schlund, B., Poschl, E., Adam, N., de Crombrugghe, B., von der Mark, K.

(2007)

BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter,

in Histochemistry and Cell Biology

127

pp. 183-194

Full Text UEA Repository

(Article)

(Published)


Mittag, J., Oehr, W., Heuer, H., Hamalainen, T., Brachvogel, B., Poschl, E., Bauer, K.

(2007)

Expression and thyroid hormone regulation of annexins in the anterior pituitary,

in Journal of Endocrinology

195

pp. 385-392

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(Article)

(Published)


Munoz, L., Franz, S., Pausch, F., Furnrohr, B., Sheriff, A., Vogt, B., Kern, P., Baum, W., Stach, C., von Laer, D., Brachvogel, B., Poschl, E., Herrmann, M., Gaipl, U.

(2007)

The influence on the immunomodulatory effects of dying and dead cells of Annexin V,

in Journal of Leukocyte Biology

81

pp. 6-14

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(Article)

(Published)


von der Mark, H., Poschl, E., Lanig, H., Sasaki, T., Deutzman, R., von der Mark, K.

(2007)

Distinct Acidic Clusters and Hydrophobic Residues in the Alternative Splice Domains X1 and X2 of alpha7 Integrins Define Specificity for Laminin Isoforms,

in Journal of Molecular Biology

371

pp. 1188-1203

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(Article)

(Published)


Schmidl, M., Adam, N., Surmann-Schmitt, C., Hattori, T., Stock, M., Dietz, U., Decrombrugghe, B., Poschl, E., von der Mark, K.

(2006)

Twisted gastrulation modulates BMP- induced collagen II and X expression in chondrocytes in vitro and in vivo,

in Journal of Biological Chemistry

281

pp. 31790-31800

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(Article)

(Published)


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Key Research Interests

 The group is interested in three major topics:
• The analysis of components of the extracellular matrix and the their biological functions in vivo
• The biological functions of the prototype member of the annexin protein family, Annexin A5
• The role of perivascular cells during angiogenesis and regenerative processes in skeletal muscle

Current Research Projects
 

• Analysis of the consequences of the deficiency of the major collagen IV isoform α1.α1.α2(IV) in vivo by the use of knockout mouse models
• Roles of annexin A5 deficiency in knockout mouse models on diverse biological processes, like calcification of cartilage and bone, vascular development and apoptosis
• Analysis of the role of annexin A5 in modulating the phagocytosis of apoptotic cells in vivo, the induction of immune reactions and autoimmunity
• In vivo functions of murine pericytes, phenotype analysis and their role in angiogenesis 
• Exploration of the potential capacities of pericytes as stem cells for differentiation to mesenchymal lineages (adipogenic, osteoblastic, chondrogenic) 
• Contributions of pericytes and satellite cells during muscle regeneration in normal tissues and in various muscle diseases


PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

External Activities and Indicators of Esteem

  • Organizer of the DFG-Schwerpunkt Symposium 'Genetic and molecular analysis of basement membranes and membrane anchorage ' (Kloster Irsee; 04/2005)
  • Invited speaker - Joint Meeting of the German/French Connective Tissue Socienties, 2004
  • Invited speaker - Modulation of immune reactions by dying cells and the phosphatidyl-serine ligand annexinA5; Annexins. Catalina Island, 2007
  • Invited speaker - Novel attempts to analyze angiogenesis and the role of collagen IV. XIIIth International Symposium on Basement Membranes, 2007
  • Invited speaker - Annexin A5, Collagen IV, Angiogenesis, Stem cells, Muscle and everything else. Symposium Münster, 2008
  • Invited speaker - Mimicking angiogenic differentiation and maturation in vitro. University Cardiff, 2008
  • Invited speaker - Annexin A5 gene expression is a novel marker for analysing vascular differentiation and tissue regeneration; Annexins. Lacanau, 2009

Administrative Posts

  • School Radiation Protection Officer
  • Member of the exam board (Chemistry)