Biography

Andrew Gates joined the School of Biological Sciences as a lecturer in 2011. He is a member of the Molecular Microbiology theme and the Centre for Molecular and Structural Biochemistry (CMSB). Andrew holds a BSc (Hons) degree in Molecular Biology from the Faculty of Medicine at the University of Newcastle upon Tyne and a PhD in Chemistry from the University of East Anglia. Prior to his appointment within the School of Biological Sciences, he worked with Prof David Richardson (UEA) and Prof Stuart Ferguson (Oxford) as a senior post-doctoral research associate, which initiated his interest in the genetics and biochemistry of assimilatory nitrate reduction, and nitrogen and iron respiratory systems in bacteria.

ResearcherID: www.researcherid.com/rid/F-8218-2011

Career History

  • 2011 to Present - University of East Anglia. Lecturer in Bacterial Bioenergetics.
  • 2008 to 2011 - University of East Anglia. Senior Research Associate.
  • 2003 to 2007 - University of East Anglia. PhD Chemistry.
  • 2000 to 2003 - University of Newcastle upon Tyne. BSc (Hons) Molecular Biology, Class I.

All Publications

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Edwards, M. J., Gates, A. J., Butt, J. N., Richardson, D. J., Clarke, T. A.

(2017)

Comparative Structure-Potentio-Spectroscopy of the Shewanella Outer Membrane Multiheme Cytochromes,

in Current Opinion in Electrochemistry

Full Text UEA Repository

(Article)

(E-pub ahead of print)


Luque-Almagro, V. M., Manso, I., Sullivan, M. J., Rowley, G., Ferguson, S. J., Moreno-Vivián, C., Richardson, D. J., Gates, A. J., Roldán, M. D.

(2017)

Transcriptional and translational adaptation to aerobic nitrate anabolism in the denitrifier Paracoccus denitrificans,

in Biochemical Journal

474

(11)

pp. 1769-1787

Full Text UEA Repository

(Article)

(Published)


Hartop, K., Sullivan, M., Giannopoulos, G., Gates, A., Bond, P., Yuan, Z., Clarke, T., Rowley, G., Richardson, D.

(2017)

The metabolic impact of extracellular nitrite on aerobic metabolism of Paracoccus denitrificans,

in Water Research

113

pp. 207–214

Full Text UEA Repository

(Article)

(Published)


Goddard, A. D., Bali, S., Mavridou, D. A., Luque-Almagro, V. M., Gates, A. J., Roldán, M. D., Newstead, S., Richardson, D. J., Ferguson, S. J.

(2017)

The Paracoccus denitrificans NarK-like nitrate and nitrite transporters; probing nitrate uptake and nitrate/nitrite exchange mechanisms,

in Molecular Microbiology

103

(1)

pp. 117–133

Full Text UEA Repository

(Article)

(Published)


Waller, Z. A. E., Pinchbeck, B. J., Buguth, B. S., Meadows, T. G., Richardson, D. J., Gates, A. J.

(2016)

Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA,

in Chemical Communications

52

(92)

pp. 13511-13514

Full Text UEA Repository

(Article)

(Published)


Gaimster, H., Chalklen, L., Alston, M., Munnoch, J. T., Richardson, D. J., Gates, A. J., Rowley, G.

(2016)

Genome-Wide Discovery of Putative sRNAs in Paracoccus denitrificans Expressed under Nitrous Oxide Emitting Conditions,

in Frontiers in Microbiology

7

article no. 1806

Full Text UEA Repository

(Article)

(Published)


Cabrera, J. J., Salas, A., Torres, M. J., Bedmar, E. J., Richardson, D. J., Gates, A. J., Delgado, M. J.

(2016)

An integrated biochemical system for nitrate assimilation and nitric oxide detoxification in Bradyrhizobium japonicum,

in Biochemical Journal

473

(3)

pp. 297-309

Full Text UEA Repository

(Article)

(Published)


Torres, M., Simon, J., Rowley, G., Bedmar, E., Richardson, D., Gates, A., Delgado, M.

(2016)

Nitrous oxide metabolism in nitrate-reducing bacteria: Physiology and regulatory mechanisms,

in Advances in Microbial Physiology

68

pp. 353-432

Full Text UEA Repository

(Article)

(Published)


Day, H. A., Wright, E. P., MacDonald, C. J., Gates, A. J., Waller, Z. A. E.

(2015)

Reversible DNA i-motif to hairpin switching induced by copper(II) cations,

in Chemical Communications

51

(74)

pp. 14099-14102

Full Text UEA Repository

(Article)

(Published)


Butt, J., Gates, A., Marritt, S., Richardson, D.

(2015)

Enzyme Film Electrochemistry,

in Electrochemical Processes in Biological Systems.

Wiley-Blackwell

pp. 105-120

ISBN 978-0-470-57845-2

(Chapter (peer-reviewed))

(Published)


Bowater, R. P., Gates, A. J.

(2015)

Nucleotides: Structure and Properties,

in eLS

Full Text

(Literature review)

(Published)


Edwards, M. J., Baiden, N., Johs, A., Tomanicek, S. J., Liang, L., Shi, L., Fredrickson, J. K., Zachara, J. M., Gates, A. J., Butt, J. N., Richardson, D. J., Clarke, T. A.

(2014)

The X-ray crystal structure of Shewanella oneidensis OmcA reveals new insight at the microbe-mineral interface,

in FEBS Letters

588

(10)

pp. 1886-1890

Full Text UEA Repository

(Article)

(Published)


Sullivan, M. J., Gates, A. J., Appia-Ayme, C., Rowley, G., Richardson, D. J.

(2013)

Copper control of bacterial nitrous oxide emission and its impact on vitamin B12-dependent metabolism,

in Proceedings of the National Academy of Sciences of the United States of America (PNAS)

110

(49)

pp. 19926-31

Full Text UEA Repository

(Article)

(Published)


Luque-Almagro, V. M., Lyall, V. J., Ferguson, S. J., Roldán, M. D., Richardson, D. J., Gates, A. J.

(2013)

Nitrogen Oxyanion-dependent Dissociation of a Two-component Complex That Regulates Bacterial Nitrate Assimilation,

in The Journal of Biological Chemistry

288

(41)

pp. 29692-702

Full Text UEA Repository

(Article)

(Published)


Woolfenden, H., Gates, A., Bocking, C., Blyth, M., Richardson, D., Moulton, V.

(2013)

Modeling the effect of copper availability on bacterial denitrification,

in MicrobiologyOpen

2

(5)

pp. 756-765

Full Text UEA Repository

(Article)

(Published)


Gates, A. J., Marritt, S. J., Bradley, J. M., Shi, L., McMillan, D. G. G., Jeuken, L. J. C., Richardson, D. J., Butt, J. N.

(2013)

Electrode assemblies composed of redox cascades from microbial respiratory electron transfer chains,

in Biochemical Society Transactions

41

(5)

pp. 1249-1253

Full Text UEA Repository

(Article)

(Published)


Felgate, H., Giannopoulos, G., Sullivan, M., Gates, A., Clarke, T., Baggs, E., Rowley, G., Richardson, D.

(2012)

The impact of copper, nitrate and carbon status on the emission of nitrous oxide by two species of bacteria with biochemically distinct denitrification pathways,

in Environmental Microbiology

14

(7)

pp. 1788-1800

Full Text UEA Repository

(Article)

(Published)


Richardson, D., Butt, J., Fredrickson, J., Zachara, J., Shi, L., Edwards, M., White, G., Baiden, N., Gates, A., Marritt, S., Clarke, T.

(2012)

The ‘porin-cytochrome’ model for microbe-to-mineral electron transfer,

in Molecular Microbiology

85

(2)

pp. 201-212

Full Text UEA Repository

(Article)

(Published)


Richardson, D., Edwards, M., White, G., Baiden, N., Hartshorne, R., Fredrickson, J., Shi, L., Zachara, J., Gates, A., Butt, J., Clarke, T.

(2012)

Exploring the biochemistry at the extracellular redox frontier of bacterial mineral Fe(III) respiration,

in Biochemical Society Transactions

40

(3)

pp. 493-500

Full Text UEA Repository

(Article)

(Published)


Clarke, T., Edwards, M., Gates, A., Hall, A., White, G., Bradley, J., Reardon, C., Shi, L., Beliaev, A., Marshall, M., Wang, Z., Watmough, N., Fredrickson, J., Zachara, J., Butt, J., Richardson, D.

(2011)

Structure of a bacterial cell surface decaheme electron conduit,

in Proceedings of the National Academy of Sciences

108

(23)

pp. 9384-9389

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

Bacterial respiratory metabolism is highly adaptable and responsive to a changing environment. This versatility relies on the ability of the cell to employ a multitude of metalloproteins to harness energy from a variety of metabolic pathways. The global biogeochemical nitrogen cycle is essential to life and many processes are carried out by microbes, either to produce energy, or to capture bioavailable nitrogen for growth. My research group is part of the Molecular Microbiology theme and mainly focuses on investigating the role of proteins associated with the perception, trafficking, and transformation of nitrate, and nitrite, in denitrifying organisms.

We employ an interdisciplinary outlook and combine classical molecular genetics with biochemical and biophysical methods to study novel molecular enzymology and microbial physiology that underpin the nitrogen and iron cycles. As part of the Centre for Molecular and Structural Biochemistry (CMSB), we also use a range of techniques such as Electron Paramagnetic Resonance (EPR) spectroscopy and Protein Film Electrochemistry (PFE) to elucidate the redox properties and catalytic mechanism of metal-containing redox enzymes.

Recently, with Professor David Richardson and Dr Gary Rowley, we have extended our research interests to the study of, and development of mitigation strategies for, nitrous oxide production by nitrate-utilising microbes as part of the Nitrous Oxide Research Alliance (NORA). In addition, we have developed a strong international network of collaborators to study the regulation and biochemistry of nitrate-utilisation in diverse denitrifying bacteria and archaea.

Nitrous Oxide Research Alliancehttp://nora.umb.no/

 

PhD, Postdoctoral & Fellowship Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

I am more than happy to explore funding opportunities, project ideas and mentor researchers wishing to visit our laboratory to undertake postdoctoral work or perform collaborative research. Possible funding routes include EU Marie Curie or Royal Society fellowships.

Also, I would be happy to develop RCUK grant applications in partnership with early career researchers who demonstrate exceptional promise and motivation, and have a keen interest in bacterial metabolism or metalloprotein biology.

 

Research Funding

The Biochemical Society (Summer Vacation Studentship) - Making ends meet: novel forms of bacterial DNA ligases from Paracoccus denitrificans

PI: Richard P Bowater. CoI: Andrew J Gates

03/07/2017 – 28/08/2017

£1,600

European Union (Horizon 2020) - Bridging Structural Biology with Biological Synthesis and Self Assembly to Reveal Key Processes in Living Systems

PI: Richard P Bowater. CoI: Julea N Butt, Thomas A Clarke, Andrew J Gates, Christopher J Hamilton, Matthew I Hutchings, Nicholas E Le Brun, Gary Rowley, Mark Searcey, Zoë A E Waller

01/01/2016 - 31/12/2018

£58,088

Ministerio de Economia y Competitividad (Spanish Ministry) - Strategies for mitigating emissions of the greenhouse gas nitrous oxide from agricultural crops (AGL2013-45087-R)

PI: María J Delgado. CoI: Lars R Bakken, Emilio Bueno Romero, Elizabeth Baggs, Andrew J Gates, Germán Tortosa Muñoz, David J Richardson

30/09/2014 – 29/09/2018

£106,238

Royal Society - Investigating the role of cations in altering DNA conformation and gene expression in bacteria (RG140746)

PI: Andrew J Gates. CoI: Zoë A E Waller

16/03/2015 – 15/03/2016

£14,447

Ministerio de Economia y Competitividad (Spanish Ministry) - Haloarchaeal contribution to climate change: Innovative applications to waste water treatment and uses of biomass produced (CTM2013-43147-R)

PI: Rosa M Martinez-Espinosa. CoI: Lars R Bakken, Andrew J Gates, Julia M Esclapez-Espliego, David J Richardson, Vanesa B Saiz, Jörg Simon

30/09/2014 – 29/09/2018

£81,630

John and Pamela Salter Charitable Trust - Investigating control of bacterial nitrate and nitrous oxide metabolism by DNA secondary structures

PI: Andrew J Gates. CoI: Zoë A E Waller

01/10/2014 – 30/09/2015

£1,889

BBSRC (New Investigator) - Investigating widespread regulation of nitrogen assimilation at the level of RNA in bacteria (BB/M00256X/1)

PI: Andrew J Gates

01/09/2014 - 31/08/2017

£399,571

Royal Society (International Exchanges Scheme) - A new integrated system for nitrate assimilation and nitric oxide detoxification (IE140222)

01/09/2014 - 31/08/2017

PI: Andrew J Gates. CoI: María J Delgado

£10,800

BBSRC - The molecular interface of microbe-mineral electron transfer (BB/L023733/1)

PI: David J Richardson. CoI: Julea N Butt, Thomas A Clarke, Marcus J Edwards, Andrew J Gates

30/09/2014 - 29/09/2017

£355,043

BBSRC - The regulation of bacterial nitrous oxide reduction (BB/L022796/1)

PI: Gary Rowley. CoI: Andrew J Gates, Nicolas E Le Brun, David J Richardson, Matthew J Sullivan

20/08/2014 - 19/08/2017

£443,401

BBSRC (Follow-on Fund Pathfinder Scheme) – Proposal Ref. BB/FOF/PF/22/13

PI: David J Richardson. CoI: Andrew J Gates

01/11/2013 - 30/04/2014

£6,312

The Big C Appeal - Student Bursary (SB13-04)

PI: Zoë A E Waller. CoI: Richard P Bowater, Andrew J Gates

29/07/2013 – 20/09/2013

£1,400

European Union (Marie Curie ITN, Framework 7) - The Nitrous Oxide Research Alliance Training Network (316472, FP7-PEOPLE-2012-ITN)

PI: Åsa H Frostegård. CoI: Andrew J Gates, David J Richardson, Gary Rowley (and other EU partners)

01/01/2013 – 31/12/2016

£1,959,457 (Institutional award £237,647)

UEA Proof of Concept Innovation Fund - Proposal Ref. i295

PI: Andrew J Gates

19/07/2012 – 31/12/2013

£24,976

Research Group Membership

Group Members:

  • Dr Nanakow Baiden (BBSRC-funded PDRA)
  • Mr Alexander Jarvis (UEA-funded PhD Student)
  • Ms Ana Salas (Spanish Ministry-funded PhD Student; co-PI Dr Maria Delgado, CSIC Granada, Spain)
  • Mr Manuel Soriano-Laguna (EU Horizon 2020-funded Early Career Researcher & PhD Student)

Extended Group Members:

  • Dr Marcus Edwards (BBSRC-funded PDRA; PI Prof David Richardson UEA VCO)
  • Dr Hannah Gaimster (BBSRC-funded PDRA; PI Dr Gary Rowley UEA BIO)
  • Mr Mahmoud Abdelhamid (Eastern Arc Consortium-funded PhD Student; PI Dr Zoë Waller, UEA PHA)
  • Ms Sophie Bennett (BBSRC-funded PhD Student; PI Prof Nick LeBrun, UEA CHE)
  • Ms Amy Easey (BBSRC-funded PhD Student; PI Dr Richard Bowater, UEA BIO)
  • Ms Isabel Johnston (UEA-funded PhD Student; PI Dr Gary Rowley, UEA BIO)

Former Group Members:

  • Ms Annabelle Schofield (Biochemical Society Summer Research Student)
  • Mr Alexander Goodchild (BBSRC-funded PhD Student; PI Dr Gary Rowley UEA BIO)
  • Ms Lindsey Wiggins (Undergraduate Research Student, 2017)
  • Mr Oliver Hayward (BBSRC-funded Research Technician, 2014-2017)
  • Mr Benjamin Pinchbeck (UEA-funded PhD Student, 2012-2016)
  • Dr Shun Tse (PhD Student, 2011-2015; PI Dr Nick Watmough, UEA BIO)
  • Dr Anthony Blake (Industry-funded PDRA, 2013)
  • Ms Fatuma Abdi (Undergraduate Research Student, 2016)
  • Mr Nathan Voller (Undergraduate Research Student, 2016)
  • Ms Emma Nicholls (EU-funded Summer Student, 2014 & 2016)
  • Ms Alice Gregorie (EU-funded Summer Student, 2014 & 2016)
  • Ms Surina Fordington (EU-funded Summer Student, 2014)
  • Mr Alexander Sheeka (Undergraduate Research Student, 2014)
  • Mr Joseph Seager (Undergraduate Research Student, 2013)
  • Ms Jasmine Stigloe (Undergraduate Research Student, 2013)
  • Ms Lidya Ashmore (Undergraduate Research Student, 2012)

Teaching Interests

  • Lecturer: BIO-6004A "Microbial Biochemistry" Undergraduate Degree Course, Year 3.
  • Lecturer and Seminar Leader: BIO-4009Y "Foundations for Chemistry and Physiology" Undergraduate Degree Course, Year 1.
  • Lecturer and Seminar Leader: BIO-4007Y "Physical and Analytical Methods in the Biomolecular Sciences" Undergraduate Degree Course, Year 1.
  • Lecturer and Seminar Leader: BIO-4011Y "Foundations for Chemistry and Physiology with Higher Chemistry" Undergraduate Degree Course, Year 1.
  • Lecturer and Practical Leader: BIO-5002A "Biochemistry" Undergraduate Degree Course, Year 2.
  • Project Supervisor: BIO-6019Y "Laboratory-based Research Project" Undergraduate Degree Course, Year 3.
  • Undergraduate Student Advisor (Biochemistry, Biological Sciences and Natural Sciences Degree Programmes).
  • Postgraduate Student Supervisor (MSc and PhD).

External Activities and Indicators of Esteem

  • Invited Speaker at the 22nd European Nitrogen Cycle Meeting (Córdoba, Spain), September 2017
  • External Examiner for PhD candidate at the University of York, December 2016
  • Co-organiser of the 21st European Nitrogen Cycle (Norwich, UK), September 2016
  • Invited Lecture at the Department of Agrochemistry and Biochemistry, University of Alicante (Alicante, Spain), December 2015
  • Invited Speaker at the Joint CMSB-ELSA Workshop on Metals in Life and the Environment (Norwich Research Park, UK), May 2015
  • Invited Lecture at the Department of Microbiology, Swedish University of Agricultural Sciences (Uppsala, Sweden), April 2015
  • Awarded Fellow of the Higher Education Academy status, February 2015
  • External Examiner for Masters by Research candidate at the University of Exeter, January 2015
  • Invited Lecturer and Workshop Leader at the Nitrous Oxide Research Alliance Summer School (Oslo, Norway), November 2014
  • Invited Plenary Speaker at the 19th European Nitrogen Cycle Meeting (Gent, Belgium), September 2014
  • Trainer for the Biochemical Society Breakthrough Science Event: Biophysical Techniques for Probing Biological Systems (Norwich, UK), July 2014
  • External Examiner for PhD Candidate at the Norwegian University of Life Sciences (NMBU), June 2014
  • Elected Member of the Royal Society of Chemistry (RSC), 2014 - present
  • Member of the Society for Applied Microbiology (SfAM), 2014 - present
  • Member of the Society for General Microbiology (SGM), 2014 - present
  • Invited Reviewer for the Biotechnology and Biological Sciences Research Council (BBSRC), 2013 - present
  • Invited lecture at the Nitrous Oxide Research Alliance Summer School (Oslo, Norway), October 2013
  • Invited Speaker at the 2nd International Conference on Nitrification and the 16th European Nitrogen Cycle Meeting (Nijmegen, Netherlands), July 2011
  • Invited Reviewer for International Journals, 2011 - present
  • Member of the Biochemical Society, 2002 - present
  • Enterprise and Engagement Activities
  • Partner of the Nitrous Oxide Research Alliance (NORA), 2013 - present

The NORA Research Project is a Marie Curie Initial Training Network (https://nora.nmbu.no/), Funded by the EU's Seventh Framework Programme (FP7)

Administrative Posts

  • Health and Safety Officer for BIO (2017-Present)
  • Member of the Athena Swan Support and Equality Team (ASSET) for BIO (2015-2017)
  • Module Coordinator: BIO-4009Y "Foundations for Chemistry and Physiology" (2011-2016)
  • Dept. Module Coordinator: BIO-4011Y "Foundations for Chemistry and Physiology (with Higher Chemistry)" (2011-2016)
  • Dept. Module Coordinator: BIO-5002A "Biochemistry"
  • Student Partnership Officer for BIO (2011-Present)
  • Member of the BIO Teaching Committee (2011-Present)