Biography

BSc from Birmingham University in 1985, and a PhD from the University of London in 1989. He was a postdoctoral fellow at Oxford University (1989-1991), and then an Alexander vonHumboldt Fellow at the Max-Planck Institute in Martinsried (1991-1993), working in Prof. Axel Ullrich’s laboratory. His first independent research group set up in 1993 at Imperial College made significant contributions to defining novel cellular pathways that regulate cell surface receptor activation and dimerisation. This led to the first evidence that transmembrane receptor kinases have specific intracellular dimerisation domains that are essential for receptor activation. Other studies have led to the identification of important cross-talk regulatory mechanisms between receptor tyrosine kinases and calcium signalling pathways. Following his move to UEA in 2000, he began to define novel links between receptor tyrosine kinases and transforming growth factor-b (TGFb), and was the first to demonstrate pathway integration between cytosolic calcium and signalling molecules known as Smad transcription factors. Recently, he established for the first time novel mechanisms for controlling Smad signalling by reversible ubiquitination, linking HECT E3 ubiquitin ligases and deubiquitinating enzymes to TGFb-dependent tumour outgrowth/metastasis.

Career History

  • Senior Lecturer in Cell Biology, University of East Anglia (2000-present)
  • Lecturer, Department of Cancer Medicine, Imperial College (1993-2000)
  • Alexander von Humboldt Fellow, Max-Planck-Institute, Munich (1991-1993)
  • Postdoctoral Fellow, University of Oxford (1989-1991)
  • Ph.D. University of London (1989)
  • B.Sc. Medical Biochemistry, University of Birmingham (1985)

All Publications

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Soond, S. M., Smith, P. G., Wahl, L., Swingler, T. E., Clark, I. M., Hemmings, A. M., Chantry, A.

(2013)

Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancer,

in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

1832

(12)

pp. 2127-2135

Full Text UEA Repository

(Article)

(Published)


Leivonen, S., Lazaridis, K., Decock, J., Chantry, A., Edwards, D., Kähäri, V.

(2013)

TGF-β-Elicited Induction of Tissue Inhibitor of Metalloproteinases (TIMP)-3 Expression in Fibroblasts Involves Complex Interplay between Smad3, p38α, and ERK1/2,

in PLoS ONE

8

(2)

article no. e57474

Full Text UEA Repository

(Article)

(Published)


Smith, P. G., Tanaka, H., Chantry, A.

(2012)

A novel co-operative mechanism linking TGFb and Lyn Kinase activation to imatinib resistance in chronic myeloid leukaemia cells,

in Oncotarget

3

(5)

pp. 518-524

UEA Repository

(Article)

(Published)


Soond, S., Chantry, A.

(2011)

How ubiquitination regulates the TGF-β signalling pathway: New insights and new players,

in BioEssays

33

(10)

pp. 749-758

Full Text UEA Repository

(Article)

(Published)


Chantry, A.

(2011)

WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targets,

in Cell Cycle

10

(15)

pp. 2437-2439

Full Text UEA Repository

(Article)

(Published)


Cutts, A., Soond, S., Powell, S., Chantry, A.

(2011)

Early phase TGFβ receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses,

in International Journal of Biochemistry & Cell Biology

43

(4)

pp. 604-612

Full Text UEA Repository

(Article)

(Published)


Soond, S., Chantry, A.

(2011)

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT,

in Oncogene

30

pp. 2451-2462

Full Text UEA Repository

(Article)

(Published)


Swingler, T., Culley, K., Nicolas, F., Soond, S., Abu-Elmagd, M., Boot-Handford, R., Young, D., Chantry, A., Munsterberg, A., Hajihosseini, M.

(2010)

066 Identification and Characterisation of Micrornas Involved in Chondrocyte Differentiation and Osteoarthritis,

Full Text UEA Repository

(Working paper)

(Published)


Pais, H., Nicolas, F., Soond, S., Swingler, T., Clark, I., Chantry, A., Moulton, V., Dalmay, T.

(2010)

Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level,

in RNA

16

(3)

pp. 489-494

Full Text UEA Repository

(Article)

(Published)


Traka, M., Gasper, A., Melchini, A., Bacon, J., Needs, P., Frost, V., Chantry, A., Jones, A., Ortori, C., Barrett, D., Ball, R., Mills, R., Mithen, R.

(2008)

Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate,

in PLoS ONE

3

(7)

article no. e2568

Full Text UEA Repository

(Article)

(Published)


Frost, V., Grocott, T., Eccles, M. R., Chantry, A.

(2008)

Self-Regulated Pax Gene Expression and Modulation by the TGFβ Superfamily,

in Critical Reviews in Biochemistry and Molecular Biology

43

(6)

pp. 371-391

Full Text UEA Repository

(Article)

(Published)


Møller, G., Frost, V., Melo, J., Chantry, A.

(2007)

Upregulation of the TGFbeta signalling pathway by Bcr-Abl: Implications for haemopoietic cell growth and chronic myeloid leukaemia.,

in FEBS Letters

581

(7)

pp. 1329-1334

Full Text UEA Repository

(Article)

(Published)


Grocott, T., Frost, V., Maillard, M., Johansen, T., Wheeler, G. N., Dawes, L. J., Wormstone, I. M., Chantry, A.

(2007)

The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter,

in Nucleic Acids Research

35

(3)

pp. 890-901

Full Text UEA Repository

(Article)

(Published)


Wicks, S., Grocott, T., Haros, K., Maillard, M., ten Dijke, P., Chantry, A.

(2006)

Reversible uniquitination regulates the Smad/TGF-beta signalling pathway.,

in Biochemical Society Transactions

34

pp. 761-763

Full Text UEA Repository

(Article)

(Published)


Wicks, S., Haros, K., Maillard, M., Song, L., Cohen, R., Dijke, P., Chantry, A.

(2005)

The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGFbeta signalling.,

in Oncogene

24

(54)

pp. 8080-8084

Full Text UEA Repository

(Article)

(Published)


Wormstone, I., Tamiya, S., Eldred, J., Lazaridis, K., Chantry, A., Reddan, J., Anderson, I., Duncan, G.

(2004)

Characterisation of TGF-beta 2 signalling and function in a human lens cell line.,

in Experimental Eye Research

78

(3)

pp. 705-714

Full Text UEA Repository

(Article)

(Published)


Oksvold, M., Thien, C., Widerberg, J., Chantry, A., Huitfeldt, H., Langdon, W.

(2004)

UV-radiation-induced internalization of the epidermal growth factor receptor requires distinct serine and tyrosine residues in the cytoplasmic carboxy-terminal domain.,

in Radiation Research

161

(6)

pp. 685-691

Full Text UEA Repository

(Article)

(Published)


Hall, M., Young, D., Waters, J., Rowan, A., Chantry, A., Edwards, D., Clark, I.

(2003)

The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1.,

in Journal of Biological Chemistry

278

(12)

pp. 10304-10313

Full Text UEA Repository

(Article)

(Published)


Oksvold, M., Thien, C., Widerberg, J., Chantry, A., Huitfeldt, H., Langdon, W.

(2003)

Serine mutations that abrogate ligand-induced uniquitination and internalization of the EGF receptor do not affect c-Cb1 association with the receptor.,

in Oncogene

22

pp. 8509-8518

Full Text UEA Repository

(Article)

(Published)


Sweetman, D., Smith, T., Farrell, E., Chantry, A., Munsterberg, A.

(2003)

The conserved glutamine rich region of chick csal1 and csal3 mediates protein interactions with other spalt family members - implications for Townes-Brocks syndrome.,

in Journal of Biological Chemistry

278

(8)

pp. 6560-6566

Full Text UEA Repository

(Article)

(Published)


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Key Research Interests

At present, his laboratory has a translational and drug discovery focus, and has projects aimed at developing novel therapeutic strategies targeting abnormal TGFb activity in cancer metastasis, leukaemia, osteoarthritis, and fibrotic disease. 

Current research projects; 

  • Novel therapeutics targeting the WWP2 Ubiquitin Ligase oncogene in malignant melanoma Novel Regulation of TGFb signalling by a protein kinase over-expressed in Breast Cancer
  • A new dual therapy approach for the treatment of chronic myeloid leukaemia
  • A new approach to target abnormal chondrocyte growth in osteoarthritis and the aging joint’

PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

                 


Teaching Interests

Course Director for the Biological Sciences degree programme, and teaches molecular and cellular biology, physiology, endocrinology, and biomedicine with an emphasis on cell signalling, ubiquitination and cancer biology.

Professional Activities

  • Editorial Board Molecular and Cellular Proteomics 2006-2016
  • Editorial Board Frontiers in Molecular and Structural Endocrinology 2010-2015

Administrative Posts

  • Course Director C100 Biological Sciences
  • Member of Exam Board
  • Chairman of BIO Library Committee
  • Member of GMO Committee
  • BIO Coursework Co-ordinator