Cell Signalling and Development
The cell signalling and development grouping focuses on dissecting signalling pathways in cell differentiation and cell fate determination in development and organogenesis and their dysregulation in human diseases.
Our research interests include:
- Signalling and disease in the eye
- Mechanisms regulating cellular responses to the TGF-β superfamily
- Role of fibroblast growth factor signalling in cell fate decisions and tissue morphogenesis
- Cytoskeletal reorganisation during epithelial cell differentiation
- Muscle development in vertebrates
- The regulation of protein secretion in epithelial cells
- Signalling tissue homeostasis in the human colonic epithelium
- Cell signalling and migration in Xenopus development
 | Dr Andrew Chantry Cell signalling mechanisms in cancer and fibrotic disease Regulation of TGFβ signalling by tyrosine kinase pathways Ubiquitination and the control of Smad function |
 | Dr Samuel Fountain Molecular mechanisms of purinergic signalling in health and disease Excitation-secretion coupling in inflammatory cells Cell signalling at the immunological synapse |
 | Dr Mohammad Hajihosseini Fgf signaling in neural cell specification and differentiation Role/s of Fgf signaling in lung and limb development Mouse models of Apert and Pfeiffer craniosynostosis syndromes |
 | Dr Mette Mogensen Microtubule reorganization during epithelial cell differentiation Microtubule anchorage at non-centrosomal sites in polarized cells The cytoskeleton in hearing and deafness |
 | Dr Andrea Münsterberg Wnt signaling pathways in vertebrate skeletal muscle Molecular and cellular mechanisms controling cell movements microRNAs in embryonic muscle differentiation |
 | Dr Paul Thomas Regulation of secretion in pancreatic acinar cells Regulation of PI 3-kinase signalling by capacitative calcium entry Role of mitochondria in signalling pathway cross-talk |
 | Dr Mark Williams Signalling self-renewal in the human intestinal epithelium ex vivo Molecular regulation of intestinal fluid secretion in health and disease Wnt signaling pathways in colon cancer initiation |
 | Dr Grant Wheeler Wnt/Frizzled signalling Metalloproteinases in Xenopus development Developmental Chemical Genetics |
 | Dr Michael Wormstone Development of in vitro models of the human eye Methods for Preventing Posterior Capsule Opacification Growth factor signalling and function |