Prof Vincent Ellis

Job Title	Contact	Location
Professor of Biological Sciences	V dot Ellis at uea dot ac dot uk Tel: +44 (0)1603 59 2570	Biology 0.17

Personal
Research
Teaching
Publications
External
Admin

Career

Professor of Biochemistry, University of East Anglia (2007-present)
Reader, University of East Anglia (2001-2007)
British Heart Foundation Senior Research Fellow, University of East Anglia (2000-2006)
Honorary Senior Lecturer, Thrombosis Research Institute, London (1995-2000)
Danish Cancer Society Senior Research Fellow, University of Copenhagen (1989-1994)
Honorary Lecturer, King's College School of Medicine, London (1987-1989)
Research Assistant/Research Fellow, King's College School of Medicine, London (1979-1986)
Ph.D. - Biochemistry, University of London (1984)
B.Sc. - Biochemistry, University of Liverpool (1978)

ResearcherID

http://www.researcherid.com/rid/D-1860-2009

Key Research Interests

My laboratory is investigating the mechanisms underlying the regulation of serine protease activity and function in pericellular proteolysis, with emphasis on the plasminogen activation system and type-II transmembrane serine protease. The aim of this research programme is to understand at the molecular level how the activity of these powerful proteolytic systems are controlled and how they becomes deregulated in various diseases, in particular those of the cardiovascular system.

Current Research Projects

Role of the type-II transmembrane serine proteases, matriptase and hepsin, in the activation of HGF/SF (hepatocyte growth factor/scatter factor)
Role of the type-II transmembrane serine protease matriptase in regulation of epithelial cell function
Cellular regulation of protase function and the control of vascular matrix remodelling
Proteolytic processing and activation of pro-neurotrophins in the cardiovascular system
Regulation of uPA-recptor function by tetraspanins and integrins.

Life in our Research Group

We use biochemical, cell and molecular biology techniques to answer research questions related to the biological activities of serine proteases. The laboratory is situated in the Biomedical Research Centre, a state-of-the-art, well equipped, open plan working environment. We are part of the Cellular Protease Group at UEA, which brings together several groups of researchers with complementary interests. We collaborate with several other research groups in the UK, Europe and North America, and students and post-doctoral researchers are encouraged to travel to collaborators research laboratories and to give presentations at international meetings.

PhD Positions

Please email me to discuss PhD opportunities and projects within the School of Biological Sciences.

Postdocs & Fellows

I am always happy to discuss possibilities for postdoctoral work, fellowships and collaborations.

Teaching Activities

Seminars in Biochemistry (1A3Y)

Introduction to Biomedicine (1A5Y)

Fundamentals of Cell Biology and Biochemistry (1A14)

Introduction to Chemistry for Life Sciences (1A61)

Biochemistry (2B01)

Molecular Biology (2B02)

Investigation of Human Disease (2B30)

Molecular Enzymology (3C01)

Biomedicine (3C34)

Jump to: Article | Book Section

Number of items: 24.

Article

Owen, KA, Qiu, D, Alves, J, Schumacher, AM, Kilpatrick, LM, Li, J, Harris, JL and Ellis, V (2010) Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA. Biochemical Journal, 426 (2). pp. 219-228. ISSN 0264-6021

Ravenhill, L, Wagstaff, L, Edwards, DR, Ellis, V and Bass, R (2010) G-helix of Maspin Mediates Effects on Cell Migration and Adhesion. Journal of Biological Chemistry, 285 (47). pp. 36285-36292. ISSN 0021-9258

Bass, R, Wagstaff, L, Ravenhill, L and Ellis, V (2009) Binding of Extracellular Maspin to 1 Integrins Inhibits Vascular Smooth Muscle Cell Migration. Journal of Biological Chemistry, 284 (40). pp. 27712-27720. ISSN 0021-9258

Bass, R and Ellis, V (2009) Regulation of urokinase receptor function and pericellular proteolysis by the integrin α5β1. Thrombosis and Haemostasis, 101 (5). pp. 954-962. ISSN 0340-6245

Gray, K and Ellis, V (2008) Activation of pro-BDNF by the pericellular serine protease plasmin. FEBS Letters, 582 (6). pp. 907-910. ISSN 00145793

Qiu, D, Owen, K, Gray, K, Bass, R and Ellis, V (2007) Roles and regulation of membrane-associated serine proteases. Biochemical Society Transactions, 35 (3). pp. 583-587. ISSN 03005127

Kilpatrick, L.M., Harris, R.L., Owen, K.A., Bass, R., Ghorayeb, C., Bar-Or, A. and Ellis, V. (2006) Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase. Blood, 108 (8). pp. 2616-2623. ISSN 0006-4971

Bass, R. and Ellis, V. (2005) Regulation of uPAR function by the integrin alpha 5 eta 1. Thrombosis and Haemostasis, 93. p. 70.

Bass, R., Werner, F., Odintsova, E., Sugiura, T., Berditchevski, F. and Ellis, V. (2005) Regulation of urokinase receptor proteolytic function by the tetraspanin CD82. Journal of Biological Chemistry, 280 (15). pp. 14811-14818. ISSN 0021-9258

Gray, K. and Ellis, V. (2005) Proteolytic processing of neurotrophin and its effect on vascular smooth muscle cell behaviour. Thrombosis and Haemostasis, 93. p. 98.

Kilpatrick, L., Owen, K., Harris, R. and Ellis, V. (2005) Dual roles of the type-II transmembrane serine proteases matriptase and hepsin in the activation of pro-uPA and HGF/SF at the cell surface. Thrombosis and Haemostasis, 93. p. 14.

Riddick, A.C., Shukla, C.J., Pennington, C.J., Bass, R., Nuttall, R.K., Hogan, A., Sethia, K.K., Ellis, V., Collins, A.T., Maitland, N.J., Ball, R.Y. and Edwards, D.R. (2005) Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues. British Journal of Cancer, 92 (12). pp. 2171-2180. ISSN 0007-0920

Dalvi, N., Thomas, G.J., Marshall, J.F., Morgan, M., Bass, R., Ellis, V., Speight, P.M. and Whawell, S.A. (2004) Modulation of the urokinase-type plasminogen activator receptor by the beta 6 integrin subunit. Biochemical and Biophysical Research Communications, 317 (1). pp. 92-99. ISSN 0006-291X

Ellis, V. (2003) Plasminogen activation at the cell surface. Current Topics in Developmental Biology, 54. pp. 263-312.

Miles, L.A. and Ellis, V. (2003) alpha-enolase comes muscling in on plasminogen activation. Thrombosis and Haemostasis, 90. pp. 564-566.

Razzaq, T.M., Bass, R., Vines, D.J., Werner, F., Whawell, S.A. and Ellis, V. (2003) Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4). Journal of Biological Chemistry, 278 (43). pp. 42679-42685. ISSN 0021-9258

Riddick, A.C.P., Barker, C., Sheriffs, I., Bass, R., Ellis, V., Sethia, K.K., Edwards, D.R. and Ball, R.Y. (2003) Banking of fresh frozen prostate tissue: methods, validation and use. British Journal of Urology Internation, 91. pp. 315-323.

Bass, R. and Ellis, V. (2002) Mechanisms regulating pericellular plasmin generation. Biochemical Society Transactions, 30. pp. 189-194.

Bass, R. and Ellis, V. (2002) Cellular mechanisms regulating non-haemostatic plasmin generation. Biochemical Society Transactions, 30. pp. 189-194.

Bass, R., Moreno Fernandez, A.M. and Ellis, V. (2002) Maspin inhibits cell migration in the absence of protease inhibitory activity. Journal of Biological Chemistry, 277 (49). pp. 46845-46848. ISSN 0021-9258

Ellis, V., Daniels, M., Misra, R. and Brown, D.R. (2002) Plasminogen activation is stimulated by prion protein and regulated in a copper-dependent manner (Accelerated Communication). Biochemistry, 41 (22). pp. 6891-6896. ISSN 0006-2960

Ellis, V. and Murphy, G. (2001) Cellular strategies for proteolytic targeting during migration and invasion. FEBS Letters, 506. pp. 1-5.

Book Section

Ellis, V (2004) Urokinase plasminogen activator. In: Handbook of Proteolytic Enzymes 2nd Edition. UNSPECIFIED. ISBN 978-0-12-079610-6

Ellis, V. (2003) Plasminogen activators - structure and function. In: Plasminogen-Structure, Activation and Regulations. Kluwer Academic/Plenum Publishers, pp. 19-46.

This list was generated on Sat Apr 6 09:31:54 2013 BST.

External Activities and Indicators of Esteem

Organiser, XIIIth International Workshop on Molecular & Cellular Biology of Plasminogen Activation, Clare College Cambridge, 2011

External PhD examiner, University of Copenhagen and University of Aarhus, Denmark

Vice-chair Gordon Research Conference "Fibrinolysis and Extracellular Proteolysis", Ventura, California, 2010

Editorial Board member (Section Editor), Thrombosis and Haemostasis (2005-present)

Biochemical Society Theme Panel member (2003-present)

Editor, Biochemical Society Transactions Vol. 30 Proceedings of Protein and Peptide Science Colloquium "Non-haemostatic Roles for Blood Coagulation Proteases and their Receptors"

Scientific committee member, XIXth Congress of the International Society on Thrombosis and Haemostasis, Birmingham, UK, 2003

Invited speaker: Gordon Research Conference "Fibrinolysis and Extracellular Proteolysis", Ventura, California, 2006

Danish Cancer Society (Kraeftens Bekaempelse) Senior Research Fellowship (1992-1994) * British Heart Foundation Senior Research Fellowship (2000-2006)

Administrative Posts/Responsibilities

Course Director for C930 Biomedicine

Module Organiser for 2B30 (Investigation of Human Disease).