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Academic

Prof Ulrike Mayer

Ulrike Mayer
Job Title Contact Location
Professor of Biology  U dot Mayer at uea dot ac dot uk
Tel: +44 (0)1603 59 2980  
Bio-Medical Research Centre (BMRC) 0.04 
  • Personal
  • Research
  • Teaching
  • Publications
  • External
  • Admin

Career

  • 2005 onwards, Professor of Cell Biology, Biomedical Research Centre, School of Biological Sciences, University of East Anglia, UK
  • 2002-2005, Senior Lecturer in Biological Sciences, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, UK
  • 2000-2002, Lecturer in Dental Genetics, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, UK
  • 1994-2000, Junior Research Leader, Max-Planck-Institute of Bochemistry, Martinsried, Germany
  • 1993, Research Assistant, Max-Planck-Research Group for Rheumatology and Immunology, University of Erlangen, Germany
  • 1988-1992, Research Assistant, Department of Exracellular Matrix Research, Max-Planck-Institute of Biochemistry, Martinsried, Germany
  • 1988, Ph.D. in Chemistry, 1988 Ludwig-Maximillian University of Munich, Germany
  • 1984, Diploma in Chemistry Albert-Ludwigs-University of Freiburg, Germany

Key Research Interests

Our group aims at understanding the role cell-extracellular matrix interaction plays in development and tissue maintenance in the adult. Using mice as a model system, we are interested to unravel the mechanisms by which cells direct extracellular matrix composition and supramolecular organisation, and vice versa, how the environment influences cellular behavior. In recent years, we have focused our research on the function of cell surface receptors for skeletal muscle maintenance and regeneration, and as potential therapeutic target in muscle wasting diseases, such as Duchenne muscular dystrophy.

Current Research Projects

  • Integrin function ins skeletal muscle.
  • Signalling mechanism in skelatal muscle.
  • Integrin function in muscle stem cell renewal and proliferation.
  • Integrin alpha7 as therapeutic target for muscle wastng diseases.

PhD Positions

Please email me to discuss PhD opportunities and projects within the School of Biological Sciences.

Teaching Activities

  • 1A4Y (Skills for Biologists)
  • 1A5Y (Introduction to Biomedicine)
  • 2B06 (Cell Biology)
  • 3C41 (Genome Biology)
  • I also offer undergraduate final year Research Projects.
Number of items: 34.

Article

Ackroyd, MR, Whitmore, C, Prior, S, Kaluarachchi, M, Nikolic, M, Mayer, U, Muntoni, F and Brown, SC (2011) Fukutin-Related Protein Alters the Deposition of Laminin in the Eye and Brain. Journal of Neuroscience, 31 (36). pp. 12927-12935. ISSN 0270-6474

Mokkapati, S, Fleger-Weckmann, A, Bechtel, M, Koch, M, Breitkreutz, D, Mayer, U, Smyth, N and Nischt, R (2011) Basement Membrane Deposition of Nidogen 1 but Not Nidogen 2 Requires the Nidogen Binding Module of the Laminin 1 Chain. Journal of Biological Chemistry, 286 (3). pp. 1911-1918. ISSN 0021-9258

Makwana, M, Werner, A, Acosta-Saltos, A, Gonitel, R, Pararajasingham, A, Ruff, C, Rumajogee, P, Cuthill, D, Galiano, M, Bohatschek, M, Wallace, AS, Anderson, PN, Mayer, U, Behrens, A and Raivich, G (2010) Peripheral facial nerve axotomy in mice causes sprouting of motor axons into perineuronal central white matter: Time course and molecular characterization. The Journal of Comparative Neurology, 518 (5). pp. 699-721. ISSN 00219967

Aigner, B, Rathkolb, B, Klaften, M, Sedlmeier, R, Klempt, M, Wagner, S, Michel, D, Mayer, U, Klopstock, T, Hrabe de Angelis, M and Wolf, E (2009) Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models. Experimental Physiology, 94 (4). pp. 412-421. ISSN 0958-0670

Han, R, Kanagawa, M, Yoshida-Moriguchi, T, Rader, EP, Ng, RA, Michele, DE, Muirhead, DE, Kunz, S, Moore, SA, Iannaccone, ST, Miyake, K, McNeil, PL, Mayer, U, Oldstone, MBA, Faulkner, JA and Campbell, KP (2009) Inaugural Article: Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of -dystroglycan. Proceedings of the National Academy of Sciences, 106 (31). pp. 12573-12579. ISSN 0027-8424

Hager, M, Meszaros, R, Bigotti, MG, Allamand, V, Akerlund, M, Kalamajski, S, Brancaccio, A, Mayer, U and Durbeej, M (2008) Cib2 binds integrin 7B 1D and is reduced in laminin 2 chain deficient muscular dystrophy. Journal of Biological Chemistry, 283. pp. 24760-24769.

Wang, H., Chang, L., Brixius, K., Wickstrom, S.A., Montanez, E., Thievessen, I., Schwander, M., Muller, U., Bloch, W., Mayer, U. and Fassler, R. (2008) Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage. Journal of Cell Biology, 180. pp. 1037-1049.

Bass, M.D., Roach, K.A., Morgan, M.R., Mostafavi-Pour, Z., Schoen, T., Muramatsu, T., Mayer, U., Ballestrem, C., Spatz, J.P. and Humphries, M.J. (2007) Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. Journal of Cell Biology, 177. pp. 527-538.

Candiello, Joseph, Balasubramani, Manimalha, Schreiber, Emmanuel M., Cole, Gregory J., Mayer, Ulrike, Halfter, Willi and Lin, Hai (2007) Biomechanical properties of native basement membranes. FEBS Journal, 274 (11). pp. 2897-2908. ISSN 1742-464X

Hanft, L.M., Bogan, D.J., Mayer, U., Kaufman, S.J., Kornegay, J.N. and Ervasti, J.M. (2007) Cytoplasmic y-actin expression in diverse animal models of muscular dystrophy. Neuromuscular Disorders, 17. pp. 569-574.

Leclere, P.G., Norman, E., Groutsi, F., Coffin, R., Mayer, U., Pizzey, J. and Tonge, D. (2007) Impaired axonal regeneration by isolectin B4-binding dorsal root ganglion neurons in vitro. Journal of Neuroscience, 27. pp. 1190-1199.

Gawlika, K., Mayer, U., Blomberg, K., Sonnenberg, A., Ekblom, P. and Durbeej, M. (2006) Laminin alpha1 chain mediated reduction of laminin alpha2 chain deficient muscular dystrophy involves integrin alpha7beta1 and dystroglycan. FEBS Letters, 580. pp. 1759-1765.

Guo, C., Willem, M., Raivich, G., Emerson, M., Neyses, L. and Mayer, U. (2006) Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy. Human Molecular Genetics, 15 (6). pp. 989-998. ISSN 0964-6906

Haubst, N., Georges-Labouesse, E., De Arcangelis, A., Mayer, U. and Gotz, M. (2006) Basement membrane attachment is dispensable for radial glial cell fate and for proliferation, but affects positioning of neuronal subtypes. Development, 133. pp. 3245-3254.

Macdonald, P.R., Progias, P., Ciani, B., Patel, S., Mayer, U., Steinmetz, M.O. and Kammerer, R.A. (2006) Structure of the extracellular domain of tie receptor tyrosine kinases and localization of the angiopoietin-binding epitope. Journal of Biological Chemistry, 281. pp. 28408-28414.

Smith, N.P., Losty, P.D., Connell, M.G., Mayer, U. and Jesudason, E.C. (2006) Abnormal lung development precedes oligohydramnios in a transgenic murine model of renal dysgenesis. Journal of Urology, 175. pp. 783-786.

Aumailley, M., Bruckner-Tuderman, L., Carter, W.G., Deutzmann, R., Edgar, D., Ekblom, P, Engel, J., Engvall, E., Hohenester, E., Jones, J.C.R., Kleinman, H.K., Marinkovich, M.P., Martin, G.R., Mayer, U. and Meneguzzi, G. + 17 others (2005) A simplified laminin nomenclature. Matrix Biology, 24. pp. 326-332.

Gardiner, N.J., Fernyhough, P., Tomlinson, D.R., Mayer, U., von der Mark, H. and Streuli, C.H. (2005) alpha7 integrin mediates axon regeneration of distinct populations of adult sensory neurons. Molecular and Cellular Neuroscience, 28. pp. 229-240.

Halfter, W., Willem, M. and Mayer, U. (2005) Basement membrane-dependent survival of retinal ganglion cells. Investigative Ophthalmology and Visual Science, 46. pp. 1000-1009.

Lopez, M.A., Mayer, U., Hwang, W., Taylor, T., Hashmi, M.A., Jannapureddy, S.R. and Boriek, A.M. (2005) Force transmission, compliance, and viscoelasticity are altered in the alpha7-integrin-null mouse diaphragm. American Journal of Physiology-Cell Physiology, 288. pp. 282-289.

Allikian, M.J., Hack, A.A., Mewborn, S., Mayer, U. and McNally, E.M. (2004) Genetic compensation for sarcoglycan loss by integrin alpha 7 beta 1 in muscle. Journal of Cell Science, 117. pp. 3821-3830.

Poschl, E., Schlotzer-Schredardt, U., Brachvogel, B., Saito, K., Ninomiya, Y. and Mayer, U. (2004) Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development, 131 (7). pp. 1619-1628. ISSN 0950-1991

Eble, J.A., Bruckner, P. and Mayer, U. (2003) Vipera lebetina venom contains two disintegrins inhibiting laminin-binding beta(1) integrins. Journal of Biological Chemistry, 278. pp. 26488-26496.

Ekstrom, P.A.R., Mayer, U., Panjwani, A., Pountney, D., Pizzey, J. and Tonge, D.A. (2003) Involvement of alpha 7 beta 1 integrin in the conditioning-lesion effect on sensory axon regeneration. Molecular and Cellular Neuroscience, 22. pp. 383-395.

Nawrotzki, R., Willem, M., Miosge, N., Brinkmeier, H. and Mayer, U. (2003) Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice. Human Molecular Genetics, 12 (5). pp. 483-495. ISSN 0964-6906

Porter, J.D., Merriam, A.P., Khanna, S., Andrade, F.H., Richmonds, C.R., Leahy, P., Cheng, G., Karathanasis, P., Zhou, X.H., Kusner, L.L., Adams, M.E., Willem, M., Mayer, U. and Kaminski, H.J. (2003) Constitutive properties, not molecular adaptations, mediate extraocular muscle sparing in dystrophic mdx mice. FASEB Journal, 17. pp. 893-895.

Previtali, S.C., Dina, G., Nodari, A., Fasolini, M., Wrabetz, L., Mayer, U., Feltri, M.L. and Quattrini, A. (2003) Schwann cells synthesize alpha 7 beta 1 integrin which is dispensable for peripheral nerve development and myelination. Molecular and Cellular Neuroscience, 23. pp. 210-218.

Sotgia, F., Bonuccelli, G., Bedford, M., Brancaccio, A., Mayer, U., Wilson, M.T., Campos-Gonzalez, R., Brooks, J.W., Sudol, M. and Lisanti, M.P. (2003) Localization of phospho-beta-dystroglycan (pY892) to an intracellular vesicular compartment in cultured cells and skeletal muscle fibers in vivo. Biochemistry, 42. pp. 7110-7123.

Halfter, W., Dong, S.C., Yip, Y.P., Willem, M. and Mayer, U. (2002) A critical function of the pial basement membrane in cortical histogenesis. Journal of Neuroscience, 22 (14). pp. 6029-6040. ISSN 0270-6474

Prince, J.M., Klinowska, T.C., Marshman, E., Lowe, E.T., Mayer, U., Miner, J., Aberdam, D., Vestweber, D., Gusterson, B. and Streuli, C.H. (2002) Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo. Developmental Dynamics, 223. pp. 497-516.

Willem, M., Miosge, N., Halfter, W., Smyth, N., Jannetti, I., Burghart, E., Timpl, R. and Mayer, U. (2002) Specific ablation of the nidogen-binding site in the laminin gamma 1 chain interferes with kidney and lung development. Development, 129 (11). pp. 2711-2722. ISSN 0950-1991

Book Section

Rogers, L.K. and Mayer, U. (2006) Insights into integrin function in skeletal muscle. In: Integrins and Development. Landes Bioscience, pp. 138-151.

Monograph

Smirnov, S., Harrison, D., Mckee, K., Mayer, U. and Yurchenco, P.D. (2006) Laminin-nidogen interaction in the induction of AChR clustering. Meeting Abstract. UNSPECIFIED.

Mayer, U. (2003) Integrins: Redundant or important players in skeletal muscle? Review. UNSPECIFIED.

This list was generated on Sat Apr 6 10:24:31 2013 BST.

External Activities and Indicators of Esteem

  • Invited Speaker at the Basement Membrane Gordon Conference, Plymouth, USA (2002)
  • Invited Speaker and session Chair at the 6th PanPacific Connective Tissue Societies Symposium, Waikoloa Village, Hawaii, USA (2005)
  • Invited review: Mayer, U. (2003) Integrins: redundant or important players in skeletal muscle? Journal of Biological Chemistry 278, 14587-14590.
  • Book chapter: Rogers, L.K. and Mayer, U. (2006). Insights into integrin function in skeletal muscle. In ‘Integrins and Development’, E. Danen, ed. (Landes Bioscience). pp 138-151

Administrative Posts/Responsibilities

  • Theme leader of the Cells and Tissue theme
  • Co-Director of the Biomedical Research Centre
  • Scientific Director of the Disease Modelling Unit
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