Dr Stephen Robinson
| Job Title | Contact | Location |
|---|---|---|
| Lecturer |
Stephen dot Robinson at uea dot ac dot uk
Tel: +44 (0)1603 59 1756 |
Bio-Medical Research Centre (BMRC) 01.02 |
Career
- June 2011 – present. Lecturer in Cell Signalling and Angiogenesis, University of East Anglia, School of Biological Sciences, Norwich Research Park, Norwich, UK.
- 2000 – May 2011. Postdoctoral Fellow, Cancer Research UK, Cell Adhesion and Disease Lab, Centre of Tumour Biology, QMUL, Bart’s Institute of Cancer, London, UK.
- 1993 - 2000. Postdoctoral Fellow, Massachusetts Institute of Technology, Boston, USA. Under the tutelage of Dr Richard O Hynes.
- 1987 - 1993. Graduate Student, University of California, Santa Cruz, CA, USA. Under the tutelage of Dr Charles W Daniel.
Key Research Interests
Much of my research to date has focused on the role of αvβ3-integrin in angiogenesis. My work as a postdoctoral fellow in the laboratory of Professor Kairbaan Hodivala-Dilke contributed to the seminal findings that αvβ3-integrin can act as a negative regulator of pathological angiogenesis (L.R. Reynolds et al., Nature Medicine 2002) and that low doses of αvβ3-integrin inhibitors can up-regulate angiogenesis (A. Reynolds et al., Nature Medicine, 2009). Recently I showed also that αvβ3-integrin regulates Neuropilin-1 (NRP1)’s function in angiogenesis (S.D. Robinson et al., Journal of Biological Chemistry, 2009).
Current Research Projects
My immediate goal, as I establish my own research group at UEA, is to determine whether we can exploit these latter findings to improve on existing angiogenic therapies. I am using a number of endothelial- and pericyte-specific mouse knockouts in models of normal and abnormal angiogenesis to determine how αvβ3-integrin and NRP1 expression regulates the angiogenic behavior of these two key cell-types. I also perform ex vivo and in vitro angiogenic assays on tissues and cells isolated from these knockout mice to determine the molecular mechanisms underlying any in vivo phenotypes uncovered.
My long-term goal is to discover novel therapeutic vascular targets that can be used to modulate angiogenesis during ageing and to control disease.
PhD Positions
Please email me to discuss PhD opportunities and projects within the School of Biological Sciences.Postdocs and Fellows
I am always happy to discuss possibilities for postdoctoral work and collaborations. Possible funding routes include applying for fellowships, e.g. Royal Society, Breast Cancer Campaign, Cancer Research UK and others, or grant applications with you as a named postdoc.Teaching Activities
- 3C27 (Cancer Biology)
- M201 (Frontiers in Molecular Medicine)
Article
Robinson, SD and Hodivala-Dilke, KM (2011) The role of β3-integrins in tumor angiogenesis: context is everything. Current Opinion in Cell Biology, 23 (5). pp. 630-637. ISSN 09550674
Tavora, B, Batista, S, Reynolds, LE, Jadeja, S, Robinson, SD, Kostourou, V, Hart, I, Fruttiger, M, Parsons, M and Hodivala-Dilke, KM (2010) Endothelial FAK is required for tumour angiogenesis. EMBO Molecular Medicine, 2 (12). pp. 516-528. ISSN 17574676
da Silva, RG, Tavora, B, Robinson, SD, Reynolds, LE, Szekeres, C, Lamar, J, Batista, S, Kostourou, V, Germain, MA, Reynolds, AR, Jones, DT, Watson, AR, Jones, JL, Harris, A, Hart, IR, Iruela-Arispe, ML, DiPersio, CM, Kreidberg, JA and Hodivala-Dilke, KM (2010) Endothelial α3β1-Integrin Represses Pathological Angiogenesis and Sustains Endothelial-VEGF. The American Journal of Pathology, 177 (3). pp. 1534-1548. ISSN 00029440
Reynolds, LE, Watson, AR, Baker, M, Jones, TA, D’Amico, G, Robinson, SD, Joffre, C, Garrido-Urbani, S, Rodriguez-Manzaneque, JC, Martino-Echarri, E, Aurrand-Lions, M, Sheer, D, Dagna-Bricarelli, F, Nizetic, D, McCabe, CJ, Turnell, AS, Kermorgant, S, Imhof, BA, Adams, R, Fisher, EMC, Tybulewicz, VLJ, Hart, IR and Hodivala-Dilke, KM (2010) Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome. Nature, 465 (7299). pp. 813-817. ISSN 0028-0836
Worth, DC, Hodivala-Dilke, K, Robinson, SD, King, SJ, Morton, PE, Gertler, FB, Humphries, MJ and Parsons, M (2010) Alpha v 3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. The Journal of Cell Biology, 189 (2). pp. 369-383. ISSN 0021-9525
D'Amico, G, Robinson, SD, Germain, M, Reynolds, LE, Thomas, GJ, Elia, G, Saunders, G, Fruttiger, M, Tybulewicz, V, Mavria, G and Hodivala-Dilke, KM (2010) Endothelial-Rac1 Is Not Required for Tumor Angiogenesis unless αvβ3-Integrin Is Absent. PLoS ONE, 5 (3). e9766. ISSN 1932-6203
Germain, M, De Arcangelis, A, Robinson, SD, Baker, M, Tavora, B, D'Amico, G, Silva, R, Kostourou, V, Reynolds, LE, Watson, A, Jones, JL, Georges-Labouesse, E and Hodivala-Dilke, K (2010) Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis. The Journal of Pathology, 220 (3). pp. 370-381. ISSN 00223417
Robinson, SD, Reynolds, LE, Kostourou, V, Reynolds, AR, da Silva, RG, Tavora, B, Baker, M, Marshall, JF and Hodivala-Dilke, KM (2009) avβ3 Integrin Limits the Contribution of Neuropilin-1 to Vascular Endothelial Growth Factor-induced Angiogenesis. Journal of Biological Chemistry, 284 (49). pp. 33966-33981. ISSN 0021-9258
D'Amico, G, Jones, DT, Nye, E, Sapienza, K, Ramjuan, AR, Reynolds, LE, Robinson, SD, Kostourou, V, Martinez, D, Aubyn, D, Grose, R, Thomas, GJ, Spencer-Dene, B, Zicha, D, Davies, D, Tybulewicz, V and Hodivala-Dilke, KM (2009) Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development, 136 (23). pp. 4043-4053. ISSN 0950-1991
Reynolds, AR, Hart, IT, Watson, AR, Welti, JC, Silva, RG, Robinson, SD, Da Violante, G, Gourlaouen, M, Salih, M, Jones, MC, Jones, DT, Saunders, G, Kostourou, V, Perron-Sierra, F, Norman, JC, Tucker, GC and Hodivala-Dilke, KM (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nature Medicine, 15 (4). pp. 392-400. ISSN 1078-8956
Reynolds, LE, Conti, FJ, Silva, R, Robinson, SD, Iyer, V, Rudling, R, Cross, B, Nye, E, Hart, IR, DiPersio, CM and Hodivala-Dilke, KM (2008) α3β1 integrin–controlled Smad7 regulates reepithelialization during wound healing in mice. Journal of Clinical Investigation, 118 (3). pp. 965-974. ISSN 0021-9738
External Activities and Indicators of Esteem
- Member - British Association for Cancer Research
- Member – The British Society for Cell Biology
