Dr Mohammad Hajihosseini
| Job Title | Contact | Location |
|---|---|---|
| Senior Lecturer |
M dot K dot H at uea dot ac dot uk
Tel: +44 (0)1603 59 1318 |
Biology 1.49 |
Career
- Senior Lecturer in Developmental Neurobiology & Biomedical Sciences - University of East Anglia, Norwich (2003- present)
- Postdoctoral fellow - University of Birmingham, UK (2001 - 2003) (The Wellcome Trust)
- Postdoctoral fellow - Imperial Cancer Research Fund (ICRF, now CRUK), Lincoln's Inn Fields, London (1996-2001) (ICRF and Human Frontiers fellowships)
- Postdoctoral fellow - National Institutes of Neurological Disorders & Stroke (NINDS), National Institutes of Health (NIH) Bethesda, USA, and Pasteur Institute, Paris, France (1994-1996) (The British Trust for Myelin Project)
- Post-graduate certificate in Higher Education Practice (PGHEP) – University of East Anglia, Norwich
- Ph.D. - Developmental Neurobiology - National Institute for Medical Research (NIMR), Mill Hill, London (1994) (Medical Research Council Studentship)
- M.Sc. - Neurological Sciences - University College London, University of London (1990)
- B.Sc. – Human Biology – King’s College London, University of London (1988)
Key Research Interests
Current Research Projects
- Investigation of the stem cells and the dynamics of neurogenesis in the adult hypothalamus
- Cellular and molecular basis of neurological defects in Apert syndrome
- Role of FGF signaling in the development of muscle and tendon progenitors
Life in our research group
We are based in the Biomedical Research Centre (BMRC) of the School of Biological Science, where we enjoy dynamic interactions with scientists of different background, from stem cell biologists and immunologists, to virologist and neuroscientists. BMRC provides a friendly atmosphere for sharing equipment, technical expertise and floor discussions. We also have ongoing collaborative studies with colleagues based in UK, USA, Japan, France and Finland, through which we share expertise, reagents and transgenic mice. We regularly use immunocytochemistry on tissue sections and cultured neural cells derived from the embryonic and adult rodent brain. Images generated from our work have won several prizes, including the annual Olympus competitions of 2007 and 2009 and runner up prize of ASGBI society in 2011..Postdocs & Fellows
Timothy G. Goodman (Post-doc; January 2011 – present)Christina M. Stratford (PhD student; October 2010 – present)
Marta Mikolajczak (PhD student; October 2012 – present)
PhD Positions
Please email me to discuss PhD opportunities and projects within the School of Biological Sciences.Teaching Activities
- Skills for Biologists (1A4Y)
- Foundations for Physiology (1A58)
- Introduction to Biomedicine (1A5Y)
- Human Physiology (2B05)
- Cell Biology (2B06)
- Blood Biomedicine (3C53)
- Cellular Signaling (3C03)
- Genomes, Genes and Genomics (3C41)
- Molecular and Cellular Principles of Developmental (3C39)
- Supervision of the research projects of final year undergraduates, and summer projects funded by the Wellcome Trust and the Company of Biologists
- External supervisor of two PhD students at the University of Giessen
Article
Königshoff, M, El Agha, E, Al Alam, D, Carraro, G, MacKenzie, B, Goth, K, De Langhe, SP, Voswinckel, R, Hajihosseini, MK, Rehan, VK and Bellusci, S (2012) Characterization of a Novel Fibroblast Growth Factor 10 (Fgf10) Knock-In Mouse Line to Target Mesenchymal Progenitors during Embryonic Development. PLoS ONE, 7 (6). e38452. ISSN 1932-6203
Swingler, TE, Wheeler, G, Carmont, V, Elliott, HR, Barter, MJ, Abu-Elmagd, M, Donell, ST, Boot-Handford, RP, Hajihosseini, MK, Munsterberg, A, Dalmay, T, Young, DA and Clark, IM (2012) The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis & Rheumatism, 64 (6). pp. 1909-1919. ISSN 00043591
Wheldon, LM, Khodabukus, N, Patey, SJ, Smith, TG, Heath, JK and Hajihosseini, MK (2011) Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model. Biochemical Journal, 436 (1). pp. 71-81. ISSN 0264-6021
Garcia-Morales, C., Liu, C-H., Abu-Elmagd, M., Hajihosseini, M.K. and Wheeler, G.N. (2009) Frizzled-10 promotes sensory neuron development in Xenopus embryos. Developmental Biology, 335(1). pp. 143-155.
Hajihosseini, M.K., Duarte, R., Pegrum, J., Donjacour, A., Lana-Elola, E., Rice, D., Sharpe, J. and Dickson, C. (2009) Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse model. Developmental Dynamics, 238. pp. 376-385.
Redshaw, N., Wheeler, G., Hajihosseini, M.K. and Dalmay, T. (2009) microRNA-449 is a putative regulator of choroid plexus development and function. Brain Research, 1250. pp. 20-26.
Tiozzo, Caterina, Langhe, Stijn De, Carraro, Gianni, Alam, Denise Al, Nagy, A, Wigfall, Clarence, Hajihosseini, Mohammad, Warburton, David, Minoo, Parviz and Bellusci, Saverio (2009) Fibroblast Growth Factor 10 Plays a Causative Role in the Tracheal Cartilage Defects in a Mouse Model of Apert Syndrome. Pediatric Research, 66 (4). pp. 386-390. ISSN 0031-3998
Hajihosseini, MK, De Langhe, SP, Lana-Elola, E, Morrison, H, Sparshott, N, Kelly, R, Sharpe, J, Rice, D and Bellusci, S (2008) Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis. Molecular and Cellular Neuroscience, 37 (4). pp. 857-868.
De Langhe, SP, Carraro, G, Li, C, Tefft, D, Xu, X, Chai, Y, Minoo, P, Hajihosseini, MK, Drouin, J, Kaartinen, V and Bellusci, S (2008) Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLOS One, 3. p. 1516.
De Langhe, S.P., Carraro, G., Warburton, D., Hajihosseini, M.K. and Bellusci, S. (2006) Levels of mesenchymal FGFR2 signalling modulate smooth muscle progenitor cell commitment in the lung. Developmental Biology, 299. pp. 52-62.
Tuddenham, Lee, Wheeler, G., Ntouniafousara, S., Waters, J., Hajihosseini, Mohammad, Clark, Ian and Dalmay, Tamas (2006) The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Letters, 580 (17). pp. 4214-4217. ISSN 00145793
Jaskoll, T., Abichaker, G., Witcher, D., Sala, F.G., Bellusci, S., Hajihosseini, M.K. and Melnick, M. (2005) FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Developmental Biology, 22. p. 11.
Hajihosseini, M.K., Lalioti, M.D., Arthaud, S., Burgar, R., Brown, J.M., Twigg, S.R., Wilkie, A.O.M. and Heath, J.K. (2004) Skeletal development is regulated by fibroblast growth factor receptor 1 signalling. Development, 113 (2). pp. 325-335. ISSN 0950-1991
Satoh, Y., Haraguchi, R., Wright, T.J., Mansour, S.L., Partanen, J., Hajihosseini, M.K., Eswarakumar, V.P., Lonai, P. and Yamada, G. (2004) Regulation of external genitalia development by concerted action of FGF ligands and FGF receptors. Anatomy and Embryology, 208. pp. 479-486.
Hajihosseini, M.K. and Heath, J.K. (2002) Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development. Mechanisms of Development, 113 (1). pp. 79-83. ISSN 0925-4773
Jaskoll, T., Zhou, Y.M., Chai, Y., Makarenkova, H.P., Collinson, J.M., West, J.D., Hajihosseini, M.K., Lee, J. and Melnick, M. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/*), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs, 170. pp. 83-98.
Hajihosseini, M.K., Wilson, S., De Moerlooze, L. and Dickson, C. (2001) A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes. Proceedings of the National Academy of Sciences USA, 98 (7). pp. 3855-3860. ISSN 0027-8424
Book Section
Hajihosseini, MK (2008) FGF Signalling in cranial suture development and pathogenesis. In: Craniofacial sutures: Development, Disease and Treatment. Front Oral Biol, Basel, Karger, pp. 160-177.
Monograph
Swingler, TE, Culley, KL, Nicolas, F, Soond, S, Abu-Elmagd, M, Boot-Handford, RP, Young, DA, Chantry, A, Munsterberg, A and Hajihosseini, M (2010) 066 Identification and Characterisation of Micrornas Inolved in Chondrocyte Differentiation and Osteoarthritis. Meeting Abstract. UNSPECIFIED.
External Activities and Indicators of Esteem
- I am regularly refereeing research proposals submitted to Wellcome Trust, BBSRC and MRC. I have also refereed for The Breast Cancer Research Campaign, Yorkshire Cancer Research, Multiple Sclerosis Society and the Netherland Organization for Scientific Research (NWO).
- I have also peer-reviewed scientific publications for the following journals: BBA Molecular Basis of Disease; Cells & Tissues Research; Cerebrospinal fluid Research; Clinical & Molecular Teratology; Developmental Dynamics: Disease, Models and Mechanisms; European Journal of Cell Biology; Journal of Anatomy; Journal of Dental Research, Journal of Neurochemistry; Journal of Neuroscience, Mechanisms of Development; Molecular & Cellular Biochemistry; Nature Genetics, and Stem Cells.
- EDITORIAL BOARD MEMBERSHIP:-
- Developmental Biology Journal
- International Scholarly Research Network
- Frontiers on Craniofacial biology
- World Journal of Clinical Pediatrics
- INVITED SPEAKER:-
- Oct. 2004 – University College London; Dept. of Anatomy & Developmental Biology.
- Nov. 2005 – King’s College London; Depts of Craniofacial Development and Orthodontics.
- Feb. 2006 – National Inst. for Medical Research, Mill Hill.
- Feb. 2006 – Lyon, France. French Connective Tissue Society meeting at the Inst. of Protein Biology and Chemistry (IBCP).
- July 2008 – Bochum, Germany. Dept. Cell Morphology & Molecular Neurobiology, Ruhr-University Bochum.
- April 2009 - Experimental Biology 2009/ FASEB – American Anatomical Society symposium: ‘FGF signaling in development and disease’, New Orleans, USA.
- July 2009 – Weatherall Institute of Molecular Medicine (WIMM), Oxford.
- Feb 2010 – MRC Harwell, Mammalian Genetics Unit.
- Feb 2011 – Institute of Psychiatry, King’s College London.
- OUTREACH:-
- July 2008 – Teacher Scientist Network (TSN) lecture on stem cells.
- Dec 2008 - Discussion on the importance and
- future of research into stem cells in; Future Radio’s Community Chest programme (http://www.podcastdirectory.com/podshows/3950428).
- March 2009 – National Brain Awareness week. Presentation on neurological diseases, and showing of the film; ‘Lorenzo’s Oil’ (http://www.myelin.org) to increase awareness of myelin-associated diseases such as ALS and Multiple Sclerosis.
Administrative Posts/Responsibilities
- Director of Post-graduate Studies
