Article

Dawes, LJ, Illingworth, CD and Wormstone, IM (2012) A fully human in vitro capsular bag model to permit intraocular lens evaluation. Ophthalmology and Visual Sciences, 53. pp. 23-29.

Eldred, JA, Hodgkinson, LM, Dawes, LJ, Reddan, JR, Edwards, DR and Wormstone, IM (2012) MMP2 Activity is Critical for TGF 2-Induced Matrix Contraction--Implications for Fibrosis. Investigative Ophthalmology & Visual Science, 53 (7). pp. 4085-4098. ISSN 0146-0404

Rhodes, JD, Lott, MC, Russell, SL, Moulton, V, Sanderson, J, Wormstone, IM and Broadway, DC (2012) Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataracts. Human Molecular Genetics, 21 (4). pp. 852-862.

Wang, L, Eldred, JA, Sidaway, P, Sanderson, J, Smith, AJO, Bowater, RP, Reddan, JR and Wormstone, IM (2012) Sigma 1 Receptor Stimulation Protect against Oxidative Damage through Suppression of the ER Stress Responses in the Human Lens. Mechanisms of Ageing and Development. (In Press)

Eldred, JA, Dawes, LJ and Wormstone, IM (2011) The lens as a model for fibrotic disease. Philosophical Transactions of the Royal Society B: Biological Sciences, 366 (1568). pp. 1301-1319. ISSN 0962-8436

Hodgkinson, LM, Wang, L, Duncan, G, Edwards, DR and Wormstone, IM (2010) ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells. Molecular Vision, 16. pp. 2765-2776.

Rhodes, JD, Russell, SL, Illingworth, CD, Duncan, G and Wormstone, IM (2009) Regional Differences in Store-Operated Ca2+ Entry in the Epithelium of the Intact Human Lens. Investigative Ophthalmology & Visual Science, 50 (9). pp. 4330-4336. ISSN 0146-0404

Dawes, Lucy, Sleeman, M. A., Anderson, I. K., Reddan, J. R. and Wormstone, Michael (2009) TGF /Smad4-Dependent and -Independent Regulation of Human Lens Epithelial Cells. Investigative Ophthalmology & Visual Science, 50 (11). pp. 5318-5327. ISSN 0146-0404

Wormstone, Michael, Wang, Lixin and Liu, Christopher S.C. (2009) Posterior capsule opacification. Experimental Eye Research, 88 (2). pp. 257-269. ISSN 00144835

Dawes, LJ, Eldred, JA, Anderson, IK, Sleeman, M, Reddan, JR, Duncan, G and Wormstone, IM (2008) TGF -Induced Contraction Is Not Promoted by Fibronectin-Fibronectin Receptor Interaction, or SMA Expression. Investigative Ophthalmology & Visual Science, 49 (2). pp. 650-661. ISSN 0146-0404

Dawes, L, Ellliott, RM, Reddan, JR, Wormstone, YM and Wormstone, IM (2007) Oligonucleotide regulated gene microarray analysis of human lens epithelial cells: TGF expresion. Molecular Vision, 13. pp. 1181-1197.

Dawes, L.J., Angell, H., Sleeman, M., Reddan, J.R. and Wormstone, I.M. (2007) TGFbeta isoform dependent Smad2/3 kinetics in human lens epithelial cells: A Cellomics analysis. Experimental Eye Research.

Duncan, G., Wang, L., Neilson, G.J. and Wormstone, I.M. (2007) Lens cell survival after exposure to stress in the closed capsular bag. Investigative Ophthalmology and Visual Science, 48. pp. 2701-2707.

Grocott, T, Frost, V, Maillard, M, Johansen, T, Wheeler, GN, Dawes, LJ, Wormstone, IM and Chantry, A (2007) The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. Nucleic Acids Research, 35 (3). pp. 890-901. ISSN 0305-1048

Hodgkinson, L.M., Duncan, G., Wang, L., Pennington, C.J., Edwards, D.R. and Wormstone, I.M. (2007) MMP and TIMP expression in quiescent, dividing and differentiating human lens cells. Investigative Ophthalmology and Visual Science, 48. pp. 4192-4199.

Zhang, H, Duncan, G, Wang, Lixin, Liu, P, Cui, H, Reddan, J, Yang, B and Wormstone, Michael (2007) Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells☆. Experimental Eye Research, 85 (6). pp. 825-835. ISSN 00144835

Wormstone, I.M., Anderson, I.K., Eldred, J.A., Dawes, L.J. and Duncan, G. (2006) Short-term exposure to transforming growth factor beta induces long-term fibrotic responses. Experimental Eye Research, 83. pp. 1238-1245.

Wormstone, I.M., Collison, D.J., Hanson, S.P. and Duncan, G. (2006) A focus on the human lens in vitro. Environmental Toxicology and Pharmacology, 21. pp. 215-221.

Wang, L., Wormstone, I.M., Reddan, J.R. and Duncan, G. (2005) Growth factor receptor signalling in human lens cells: role of the calcium store. Experimental Eye Research, 80. pp. 885-895.

Wormstone, IM, Tamiya, S, Eldred, JA, Lazaridis, K, Chantry, A, Reddan, JR, Anderson, I and Duncan, G (2004) Characterisation of TGF-beta 2 signalling and function in a human lens cell line. Experimental Eye Research, 78 (3). pp. 705-714.

Collison, D., Wang, L., Wormstone, I.M. and Duncan, G. (2004) Spatial characteristics of receptor-induced calcium signaling in human lens capsular bags. Investigative Ophthalmology and Visual Science, 45. pp. 200-205.

Duncan, G., Tamiya, S. and Wormstone, I.M. (2004) Antagonistic effects of TGF beta and EGF on gene expression in the human lens capsular bag. Investigative Ophthalmology and Visual Science, 45. p. 2332.

Maidment, J.M., Duncan, G., Tamiya, S., Collison, D., Wang, L.X. and Wormstone, I.M. (2004) Regional differences in tyrosine kinase receptor signalling components determine differential growth patterns in the human lens. Investigative Ophthalmology and Visual Science, 45 (5). pp. 1427-1435.

Wormstone, I.M., Maidment, J.M., Tamiya, S., Collison, D.J., Wang, L. and Duncan, G. (2004) Relationship between growth activity and expression of EGF receptor and downstream signalling proteins in the human lens. Investigative Ophthalmology and Visual Science, 45. p. 1710.

Duncan, G., Tamiya, S. and Wormstone, I.M. (2003) Dynamics of gene expression in the human lens capsular bag in response to transforming growth factor beta 2. Investigative Ophthalmology and Visual Science, 44. p. 4506.

Eldred, J.A., Sanderson, J., Wormstone, I.M., Reddan, J.R. and Duncan, G. (2003) Stress-induced ATP release from and growth modulation of human lens and retinal pigment epithelial cells. Biochemical Society Transactions, 31. pp. 1213-1215.

Wang, L., Wormstone, I.M., Reddan, J.R. and Duncan, G. (2003) EGF receptor signalling in human lens cells: Dependence on a functional calcium store. Investigative Ophthalmology and Visual Science, 44. p. 4503.

Duncan, G., Wormstone, I.M., Tamiya, S. and Anderson, I. (2002) TGF beta 2 and EGF regulation of MMP 2 and 9 expression in the human lens capsular bag. Investigative Ophthalmology and Visual Science, 42. p. 5007.

Maidment, J.M., Wormstone, I.M., Wang, L., Reddan, J.R. and Duncan, G. (2002) EGF-induced changes of the signalling proteins ERK1/2 in human lens epithelial cells. Investigative Ophthalmology and Visual Science, 43. p. 2348.

Maini, R., Collison, D.J., Maidment, J.M., Davies, P.D. and Wormstone, Michael (2002) Pterygial derived fibroblasts express functionally active histamine and epidermal growth factor receptors. Experimental Eye Research, 74 (2). pp. 237-244. ISSN 0014-4835

Wormstone, I. M., Tamiya, S.T., Anderson, I. and Duncan, G. (2002) TGF beta2 induced matrix modification and cell transdifferentiation in the human lens capsular bag. Investigative Ophthalmology and Visual Science, 43 (7). pp. 2301-2308. ISSN 0146-0404

Wormstone, I.M. (2002) Posterior capsule opacification: A cell biological perspective. Experimental Eye Research, 74. pp. 337-347.

Wormstone, I.M., Anderson, I. and Duncan, C. (2002) Short-term TGF beta 2 exposure mediates long-term changes in the human lens capsular bag. Investigative Ophthalmology and Visual Science, 43. p. 2984.

Wormstone, I.M., Tamiya, S., Eldred, Julie, Reddan, J.R., Anderson, J. and Duncan, G. (2002) Inhibition of TGF beta 2 mediated effects on human lens epithelial cells by the human monoclonal antibody CAT-152. Investigative Ophthalmology and Visual Science, 42. p. 2911.

Wormstone, I.M., Del Rio-Tsonis, K., McMahon, G., Tamiya, S., Davies, P.D., Marcantonio, J.M. and Duncan, G. (2001) FGF: An autocrine regulator of human lens cell growth independent of added stimuli. Investigative Ophthalmology and Visual Science, 42 (6). pp. 1305-1311. ISSN 0146-0404

Davidson, MG, Wormstone, IM, Morgan, D, Malakof, R, Allen, J and McGahan, MC (2000) Ex vivo canine lens capsular sac explants. Graefe's Archive for Clinical and Experimental Ophthalmology, 238 (8). pp. 708-714. ISSN 0721-832X

Tamiya, S, Wormstone, IM, Marcantonio, JM, Gavrilovic, J and Duncan, G (2000) Induction of Matrix Metalloproteinases 2 and 9 following Stress to the Lens. Experimental Eye Research, 71 (6). pp. 591-597. ISSN 00144835

Wormstone, IM, Tamiya, S, Marcantonio, JM and Reddan, JR (2000) Hepatocyte growth factor function and c-met expression in human lens epithelial cells. Investigative Ophthalmology and Visual Science, 41. pp. 4216-4222.

Duncan, G and Wormstone, IM (1999) Calcium cell signalling and cataract: Role of the endoplasmic reticulum. Eye, 13 (3b). pp. 480-483. ISSN 0950-222X

Hightower, KR, Duncan, G, Dawson, A, Wormstone, IM, Reddan, J and Dziedizc, D (1999) Research Note: Ultraviolet Irradiation (UVB) Interrupts Calcium Cell Signaling in Lens Epithelial Cells. Photochemistry and Photobiology, 69 (5). pp. 595-598. ISSN 0031-8655

Davidson, MG, Harned, J, Grimes, AM, Duncan, G, Wormstone, IM and McGahan, MC (1998) Transferrin in After-Cataract and as a Survival Factor for Lens Epithelium. Experimental Eye Research, 66 (2). pp. 207-215. ISSN 00144835

Duncan, G, Wormstone, IM and Davies, PD (1997) The aging human lens: structure, growth, and physiological behaviour. British Journal of Ophthalmology, 81 (10). pp. 818-823. ISSN 0007-1161

Duncan, G, Wormstone, IM, Liu, CSC, Marcantonio, JM and Davies, PD (1997) Thapsigargin-coated intraocular lenses inhibit human lens cell growth. Nature Medicine, 3 (9). pp. 1026-1028. ISSN 1078-8956

Quinlan, M, Wormstone, IM, Duncan, G and Davies, P D (1997) Phacoemulsification versus extracapsular cataract extraction: a comparative study of cell survival and growth on the human capsular bag in vitro. British Journal of Ophthalmology, 81 (10). pp. 907-910. ISSN 0007-1161

Book Section

Wormstone, IM (2010) Posterior Capsule Opacification. In: Encyclopedia of the Eye. Academic Press, Oxford, pp. 469-475. ISBN 9780123742032

Duncan, G. and Wormstone, I.M. (2001) Physiology of the lens. In: Duane's Clinical Ophthalmology. UNSPECIFIED, pp. 1-20.

Patent

6,255,338B1 Use of calcium intracellular store inactivators and formulations thereof as cell growth inhibitors. .