Dr Mette Mogensen
| Job Title | Contact | Location |
|---|---|---|
| Senior Lecturer |
M dot Mogensen at uea dot ac dot uk
Tel: +44 (0)1603 59 1037 |
Biology 0.57 |
Career
- Senior Lecturer in Cell and Developmental Biology, UEA (2009 - present)
- Lecturer in Cell and Developmental Biology, UEA (2001- 2009)
- Welcome Trust Lecturer / Research Fellow, Univ of Dundee. (1997-2000)
- Senior Postdoctoral Research Associate, Univ of St. Andrews (1991-1997)
- Postdoctoral Research Associate, University of St. Andrews (1985-1991)
- Demonstrator in Cell Biology, University of Manchester (1983-1985)
- Post Graduate Certificate in Higher Education Practice (2004)
- Ph.D. in Cell Biology, University of Manchester (1985)
- B.Sc. in Genetics and Cell Biology, University of Manchester (1980)
Key Research Interests
Current Research Projects
- Microtubule and centrosomal organisation in normal and colon cancer cells
- The role of ninein in microtubule minus-end anchorage
- The role of microtubule plus-end associated proteins in the formation of apico-basal arrays in polarised epithelial cells
- Microtubule plus and minus-end capture dynamics in epithelial cells
Life in our research group
Our group is located in a well equipped research lab within the BMRC in the School of Biological Sciences. We use a combination of cell culture and tissue model systems to study microtubule and centrosomal organisation during epithelial polarisation in normal and cancer cells. GFP- and RNAi-technology and widefield fluorescence, confocal and electron microscopy are being used for live and fixed cell analyses (see http://www.uea.ac.uk/bio/biobmi/ for our Bio-imaging facility). We have weekly lab meetings and regularly attend international conferences on the centrosome and the cytoskeleton.PhD Positions
Please email me to discuss PhD opportunities and projects within the School of Biological Sciences.Teaching Activities
- Fundamentals of Cell Biology (1A14)
- Foundations for Physiology (1A58)
- Introduction to Biomedicine (1A5Y)
- Skills for Biologists (1A4Y)
- Human Physiology (2B05)
- Advanced Cell Biology (3C18).
Article
Bellett, G., Carter, J.M., Keynton, J., Goldspink, D., James, C., Moss, D.K. and Mogensen, M.M. (2009) Microtubule plus-end and minus-end capture at adherens junctions is involved in the assembly of apico-basal arrays in polarised epithelial cells. Cell Motility and the Cytoskeleton, 66. pp. 893-908.
Kohlmaier, G., Loncarek, J., Meng, X., McEwen, B.F., Mogensen, M.M., Spektor, A., Dynlacht, B.D., Khodjakov, A. and Gonczy, P. (2009) Overly Long Centrioles and Defective Cell Division upon Excess of the SAS-4-Related Prootein CPAP. Current Biology, 19. pp. 1012-1018.
Wagstaff, L.J., Bellett, G., Mogensen, M.M. and Munsterberg, A. (2008) Multicellular rosette formation during cell ingression in the avian primitive streak. Developmental Dynamics, 237. pp. 91-96.
Dahm, R, Procter, J.E., Ireland, M.E., Lo, Woo-Kuen, Mogensen, M.M., Quinlan, R.A. and Prescott, A.R. (2007) Reorganisation of centrosomal marker proteins coincides with epithelial cell differentiation in vertebrate lens. Experimental Eye Research, 85. pp. 696-713.
Hoppeler-Lebel, A., Celati, C., Bellett, G., Mogensen, M.M., Klein-Hitpass, L., Bornens, M. and Tassin, A.M. (2007) Centrosomal CAP350 protein stabilises microtubule associated with the Golgi complex. Journal of Cell Science, 120 (18). pp. 3299-3308. ISSN 0021-9533
Mogensen, M.M., Rzadzinska, A. and Steel, K.P. (2007) The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and sterocilia development. Cell Motility and the Cytoskeleton, 64 (7). pp. 496-508. ISSN 0886-1544
Moss, D.K., Bellett, Gemma, Carter, J.M., Liovic, M., Keynton, Jennifer, Prescott, A.R., Lane, E.B. and Mogensen, M.M. (2007) Ninein is released from the centrosome and moves bi-directionally along microtubules. Journal of Cell Science, 120 (17). pp. 3064-3074. ISSN 0021-9533
Baird, D.H., Myers, K.A., Mogensen, M.M., Moss, D. and Baas, P.W. (2004) Distribution of the microtubule-related protein ninein in developing neurons. Neuropharmacology, 47. pp. 677-683.
Gromley, A., Jurczyk, A., Sillibourne, J., Halilovic, E., Mogensen, M.M., Groisman, I., Blomberg, M. and Doxsey, S. (2003) A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. Journal of Cell Biology, 161. pp. 535-545.
Keryer, G., Di Fiore, B., Celati, C., Lechtreck, K.F., Mogensen, M.M., Delouvee, A., Lavia, P., Bornens, M. and Tassin, A.M. (2003) Part of Ran is associated with AKAP450 at the Centrosome: Involvement in microtubule-organizing activity. Molecular Biology of the Cell, 14. pp. 4260-4271.
Keryer, G., Di Fiore, B., Celati, C., Lechtreck, K.F., Mogensen, M.M., Delouvee, A., Lavia, P., Bornens, M. and Tassin, A.M. (2003) Ran is associated with the centrosome through AKAP450 during interphase: Involvement in microtubule nucleation. Cell Motility and the Cytoskeleton, 54. p. 51.
Liovic, M., Mogensen, M.M., Prescott, A.R. and Lane, E.B. (2003) Observation of keratin particles showing fast bidirectional movement colocalized with microtubules. Journal of Cell Science, 116. pp. 1417-1427.
Moss, D.K., Bellett, G., Liovic, M., Piel, M., Prescott, A.R., Lane, E.B., Bornens, M. and Mogensen, M.M. (2003) Two functionally distinct centrosomal complexes are responsible for microtubule nucleation and anchorage. Cell Motility and the Cytoskeleton, 54. p. 40.
Abal, M., Piel, M., Bouckson-Castaing, V., Mogensen, M.M., Sibarita, J-B. and Bornens, M. (2002) Microtubule release from the centrosome in migrating cells. Journal of Cell Biology, 159. pp. 731-737.
Gromley, A., Blomberg-Wirschell, M., Groisman, I., Mogensen, M.M., Craig, R., Powers, C. and Doxsey, S. (2002) A mammalian centriole protein homologous to a component of the mitotic exit network plays a role in completion of cytokinesis, cell cycle progression and microtubule organization. Molecular Biology of the Cell, 12. p. 2256.
Mogensen, M.M., Tucker, J.B., Mackie, J.B., Prescott, A.R. and Nathke, I.S. (2002) The adenomatous polyposis coli protein unambiguously localizes to microtubule plus-ends and is involved in establishing parallel arrays of microtubule bundles in highly polarised epithelial cells. Journal of Cell Biology, 157 (6). pp. 1041-1048. ISSN 0021-9525
Mogensen, M.M., Tucker, J.B., Mackie, J.B., Prescott, A.R. and Nathke, I.S. (2002) Involvement of the Adenomatous Polyposis Coli Protein in establishing polar microtubule arrays in the inner ear epithelium. Molecular Biology of the Cell, 12. p. 266.
Book Section
Mogensen, M.M. (2004) Microtubule organizing centers in polarized epithelial cells. In: Centrosomes in Development and Disease. Wiley-VCH, Weinheim, pp. 299-312.
External Activities and Indicators of Esteem
- Member of BSCB, ECF and ASGBI
- Invited book chapter: Microtubule organising centres in polarised epithelial cells. In: Nigg, E.A. (Ed.) Centrosomes in Development and Disease. 2004. Wiley-VCH, Weinheim, 299-319.
- Recent invited conference talks/seminars: German Society for Cell Biology (2004); The Curie Institut, Paris, France (2004); ISREC, Lausanne, Switzerland (2006; 2009)
- BBSRC grant reviewer and manuscript reviewer for J. Cell Science and Cell Motility and the Cytoskeleton
- National and international external PhD examiner
Administrative Posts/Responsibilities
- Director of Cell Biology Degree Course C130
- Director of Year in Europe and Year in North America Degree Courses
- Module Organiser of Advanced Cell Biology (3C18)
- Member of Bio-Imaging committee
