Dr Jelena Gavrilovic
| Job Title | Contact | Location |
|---|---|---|
| Senior Lecturer |
J dot Gavrilovic at uea dot ac dot uk
Tel: +44 (0)1603 59 3816 |
Biology 0.55 |
Career
- Senior Lecturer in Cell Biology, University of East Anglia (2002-present)
- Lecturer in Cell Biology, University of East Anglia (1997-2002)
- Group Leader Strangeways Research Laboratory (1994-1997)
- Post-doctoral Associate, Strangeways Research Laboratory, Cambridge (1993-1994)
- Post-doctoral Fellow, University College London (1989-1992)
- Royal Society and EMBO Post-doctoral Fellow Ecole Normale Superieure, Paris, France(1987-1989)
- Ph.D. - Strangeways Research Laboratory, Cambridge (1987)
- B.Sc. - Cell Biology, University College London (1978)
Key Research Interests
Current Research Projects
- Mechanisms of nerve regeneration in wound healing models.
- Metalloproteinase expression and function in primary macrophages.
- Mechanisms of tumour cell migration and invasion: roles of novel invasion inhibitors.
Life in our research group
We are cell biologists studying several key disease processes. Using in vivo and in vitro approaches and state-of-the-art imaging techniques we work to unravel the complex mechanisms involved in inflammation and tumour spread including tumour-endothelial cell interactions. We also have interests in the effects of growing cells in a 3-dimensional matrix on metalloproteinase expression and cellular function in chondrocytes as well as in macrophages and tumour cells. Our work benefits from collaborations within BIO and with colleagues across the Norwich Research Park including Mark Searcey (Pharmacy, UEA), Nathalie Juge (Institute of Food Research) and David Russell (Chemistry, UEA) as well as with colleagues across Europe and in pharmaceutical companies.
PhD Positions
Please email me to discuss PhD opportunities and projects within the School of Biological Sciences.Postdocs & Fellows
I am always happy to discuss possibilities for postdoctoral work and collaborations.Teaching Activities
- I teach Cell Biology in second and third year modules and on Biomedicine modules and Masters Medical Biotechnology module
Article
Baker, N, Sharpe, P, Culley, K, Otero, M, Bevan, D, Newham, P, Barker, W, Clements, KM, Langham, CJ, Goldring, MB and Gavrilovic, J (2012) Dual regulation of metalloproteinase expression in chondrocytes by WISP3/CCN6. Arthritis & Rheumatism. n/a-n/a. ISSN 00043591 (In Press)
Galindo, F, Kabir, N, Gavrilovic, J and Russell, DA (2008) Spectroscopic studies of 1,2-diaminoanthraquinone (DAQ) as a fluorescent probe for the imaging of nitric oxide in live cells. Photochemical & Photobiological Sciences, 7 (1). pp. 126-130. ISSN 1474-905X
Galindo, F, Kabir, N, Gavrilovic, J and Russell, DA (2008) Spectroscopic studies of 1,2-diaminoanthraquinone (DAQ) as a fluorescent probe for the imaging of nitric oxide in living cells. Photochemical & Photobiological Sciences, 7 (1). pp. 126-130. ISSN 1474-905X
Zhong, J.L., Poghosyan, Z., Pennington, C.J., Scott, X., Handsley, M.M., Warn, A., Gavrilovic, J., Honert, K., Kruger, A., Span, P.N., Sweep, F.C.G.J. and Edwards, D.R. (2008) Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. Molecular Cancer Research, 6. pp. 383-394.
Worley, J.R., Hughes, D.A., Dozio, N., Gavrilovic, J. and Sampson, M.J. (2007) Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes. Cardiovascular Diabetology, 6 (1). p. 21.
Sampson, M., Wall, S., Baugh, M., Worley, J., Davies, I., Hughes, D. and Gavrilovic, J. (2006) Monocyte matrix and ADAM metalloproteinase expression in type 2 diabetes after aspirin therapy. Diabetes Research and Clinical Practice, 71. pp. 45-51.
Wieder, M.E., Hone, D.C., Cook, Mike, Handlsey, M.M., Gavrilovic, Jelena and Russell, David (2006) Intracellular Photodynamic Therapy with Photosensitizer-Nanoparticle Conjugates: Cancer Therapy Using a 'Trojan Horse'. Photochemical & Photobiological Sciences, 5 (8). pp. 727-734. ISSN 1474-9092
Galindo, Francisco, Burguete, M. Isabel, Vigara, Laura, Luis, Santiago V., Kabir, Nurul, Gavrilovic, Jelena and Russell, David A. (2005) Synthetic Macrocyclic Peptidomimetics as Tunable pH Probes for the Fluorescence Imaging of Acidic Organelles in Live Cells. Angewandte Chemie International Edition, 44 (40). pp. 6504-6508. ISSN 1433-7851
Singh, R.J., Mason, J.C., Lidington, E.A., Edwards, D.R., Nuttall, R.K., Khokha, R., Knauper, V., Murphy, G. and Gavrilovic, J. (2005) Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovascular Research, 67 (1). pp. 39-49. ISSN 0008-6363
Harrison, M., Abu-Elmagd, M., Grocott, T., Yates, C., Gavrilovic, J. and Wheeler, G.N. (2004) Matrix metalloproteinase genes in Xenopus development. Developmental Dynamics, 231 (2). pp. 214-220. ISSN 1058-8388
Sampson, M.J., Davies, I., Gavrilovic, J., Sussams, B., Brown, J., Astley, S.B. and Hughes, D.A. (2004) Plasma matrix metalloproteinases, low density lipoprotein oxidisability and soluble adhesion molecules after a glucose load in Type 2 diabetes. Cardiovascular Diabetology, 3. p. 7.
Baugh, M.D., Gavrilovic, J., Davies, I.R., Hughes, D.A. and Sampson, M.J. (2003) Monocyte matrix metalloproteinase production in Type 2 diabetes and controls - a cross sectional study. Cardiovasc Diabetol, 2. pp. 1-4.
Platt, C., Krekoski, C.A., Edwards, D.R. and Gavrilovic, J. (2003) Extracellular matrix and matrix metalloproteinases in sciatic nerve. Journal of Neuroscience Research, 74 (3). pp. 417-429. ISSN 0360-4012
Worley, J.R., Baugh, M.D., Hughes, D.A., Edwards, D.R., Hogan, A., Sampson, M.J. and Gavrilovic, J. (2003) Metalloproteinase expression in PMA stimulated THP-1 cells: effects of peroxisome proliferator-activated receptor-y (PPARy) agonists and 9-cis-retionic acid. Journal of Biological Chemistry, 278 (51). pp. 51340-51346.
Stringa, E., White, D., Tuan, R.S., Knauper, V. and Gavrilovic, J. (2002) Role of newly synthesized fibronectin in vascular smooth muscle cell migration on matrix-metalloproteinase-degraded collagen. Biochemical Society Transactions, 30. pp. 102-111.
Tamiya, S, Wormstone, IM, Marcantonio, JM, Gavrilovic, J and Duncan, G (2000) Induction of Matrix Metalloproteinases 2 and 9 following Stress to the Lens. Experimental Eye Research, 71 (6). pp. 591-597. ISSN 00144835
External Activities and Indicators of Esteem
- British Society of Matrix Biology Committee Member 2006-2010.
- Organiser of BSMB meeting at UEA September 6th/7th 2010 “Inflammation Meets Matrix Biology”.
Administrative Posts/Responsibilities
- Module Organiser for second year Cell Biology (2B06)
- Director of Enterprise for School of Biological Sciences, UEA
