Article

Haigney, A, Lukacs, A, Brust, R, Zhao, R, Towrie, M, Greetham, GM, Clark, I, Illarionov, B, Bacher, A, Kim, R-R, Fischer, M, Meech, SR and Tonge, PJ (2012) Vibrational Assignment of the Ultrafast Infrared Spectrum of the Photoactivatable Flavoprotein AppA. The Journal of Physical Chemistry B, 116 (35). pp. 10722-10729. ISSN 1520-6106

Ollivere, B, Wimhurst, JA, Clark, IM and Donell, SM (2012) Current concepts in osteolysis. Journal of Bone and Joint Surgery - British Volume, 94-B (1). pp. 10-15. ISSN 0301-620X

Swingler, TE, Wheeler, G, Carmont, V, Elliott, HR, Barter, MJ, Abu-Elmagd, M, Donell, ST, Boot-Handford, RP, Hajihosseini, MK, Munsterberg, A, Dalmay, T, Young, DA and Clark, IM (2012) The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis & Rheumatism, 64 (6). pp. 1909-1919. ISSN 00043591

Wilkinson, JM, Davidson, RK, Swingler, TE, Jones, ER, Corps, AN, Johnston, P, Riley, GP, Chojnowski, AJ and Clark, IM (2012) MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction. BBA - Biochimica et Biophysica Acta. (In Press)

Fields, J, Gardner-Mercer, J, Borgmann, K, Clark, IM and Ghorpade, A (2011) CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1. Journal of Neurochemistry, 118. pp. 93-104. ISSN 00223042

Milner, JM, Patel, A, Davidson, RK, Swingler, TE, Desilets, A, Young, DA, Kelso, EB, Donell, ST, Cawston, TE, Clark, IM, Ferrell, WR, Plevin, R, Lockhart, JC, Leduc, R and Rowan, AD (2010) Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis and rheumatism, 62 (7). pp. 1955-1966. ISSN 1529-0131

Milner, JM, Patel, A, Davidson, RK, Swingler, TE, Desilets, A, Young, DA, Kelso, EB, Donell, ST, Cawston, TE, Clark, IM, Ferrell, WR, Plevin, R, Lockhart, JC, Leduc, R and Rowan, AD (2010) Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis & Rheumatism, 62 (4). pp. 1955-1966. ISSN 00043591

Scott, JL, Gabrielides, C, Davidson, RK, Swingler, TE, Clark, IM, Wallis, GA, Boot-Handford, RP, Kirkwood, TBL, Talyor, RW and Young, DA. (2010) Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Annals of the Rheumatic Diseases, 69 (8). pp. 1502-1510. ISSN 0003-4967

Pais, H, Nicolas, FE, Soond, S, Swingler, T, Clark, I, Chantry, A, Moulton, V and Dalmay, T (2010) Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level. RNA, 16 (3). pp. 489-494. ISSN 1355-8382

Barter, MJ, Pybus, L, Litherland, GJ, Rowan, AD, Clark, IM, Edwards, DR, Cawston, TE and Young, DA (2010) HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes. Matrix Biology, 29 (7). pp. 602-612. ISSN 0945053X

Swingler, TE, Kevorkian, L, Culley, KL, Illman, SA, Young, DA, Parker, AE, Lohi, J and Clark, IM (2010) MMP28gene expression is regulated by Sp1 transcription factor acetylation. Biochemical Journal, 427 (3). pp. 391-400. ISSN 0264-6021

Williams, FMK, Skinner, J, Spector, TD, Cassidy, A, Clark, IM, Davidson, RM and Macgregor, AJ (2010) Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action. BMC Musculoskeletal Disorders, 11 (1). p. 280. ISSN 1471-2474

Rodgers, U.R., Kevorkian, L., Surridge, A.K., Waters, J.G., Swingler, T.E., Culley, K., Illman, S., Lohi, J., Parker, A.E. and Clark, I.M. (2009) Expression and function of matrix metalloproteinase (MMP)-28. Matrix Biology, 28. pp. 263-272.

Surridge, A.K., Rodgers, U.R., Swingler, T.E., Davidson, R.K., Kevorkian, L., Norton, R., Waters, J.G., Goldring, M.B., Parker, A.E. and Clark, I.M. (2009) Characterization and regulation of ADAMTS-16. Matrix Biology, 28. pp. 416-424.

Swingler, T.E., Waters, J.G., Davidson, R.K., Pennington, C.J., Puente, X.S., Darrah, C., Cooper, A., Donell, S.T., Guile, G.R., Wang, W. and Clark, I.M. (2009) Degradome expression profiling in human articular cartilage. Arthritis Research & Therapy, 11. p. 96.

Clark, IM, Swingler, TE, Sampieri Ramirez, CL and Edwards, DR (2008) The regulation of matrix metalloproteinases and their inhibitors. The International Journal of Biochemistry & Cell Biology, 40 (6-7). pp. 1362-1378. ISSN 13572725

Clark, I, Macgregor, A and Donell, ST (2008) The genetic association between asporin and osteoarthritis. The Knee, 15 (3). vii-viii.

Johnston, P., Larson, D., Clark, I.M. and Chojnowski, A.J. (2008) Metalloproteinase gene expression correlates with clinical outcome in Dupuytren's disease. Journal of Hand Surgery - American Volume, 33. pp. 1160-1167.

Sampieri, C.L., Nuttall, R.K., Young, D.A., Goldspink, D., Clark, I.M. and Edwards, D.R. (2008) Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes. Matrix Biology, 27. pp. 128-138.

Zhang, Q., Hu, Wi, Litherland, G.J., Barter, M.J., Davidson, Rosemary, Darrah, C., Donell, ST, Clark, I.M., Cawston, T.E., Robinson, J.H., Rowan, A.D. and Young, D.A. (2008) Differential Toll-like receptor-dependent collagenase expression in chondrocytes. Annals of the Rheumatic Diseases, 67. pp. 1633-1641.

Johnston, P, Chojnowski, A, Davidson, R, Riley, Graham, Donell, S and Clark, I (2007) A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease. The Journal of Hand Surgery, 32 (3). pp. 343-351. ISSN 03635023

Clark, I.M., Swingler, T.E. and Young, D.A. (2007) Acetylation in the regulation of MMP and TIMP gene expression. Frontiers in Bioscience, 12. pp. 528-535.

Johnston, P., Chojnowski, A.J., Davidson, R.K., Riley, G.P., Donell, S.T. and Clark, I.M. (2007) A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren's Disease. Journal of Hand Surgery - American Volume, 32. pp. 343-351.

Jones, GC, Corps, AN, Pennington, CJ, Clark, IM, Edwards, DR, Bradley, MM, Hazleman, BL and Riley, GP (2006) Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon. Arthritis & Rheumatism, 54 (3). pp. 832-842. ISSN 0004-3591

Davidson, R.K., Waters, J.G., Kevorkian, L., Darrah, C., Cooper, A., Donell, S.T. and Clark, I.M. (2006) Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage. Arthritis Research and Therapy, 8 (4). p. 124.

Engers, R., Springer, E., Kehren, V., Simic, T., Young, D.A., Beier, J., Klotz, L.O., Clark, I.M., Sies, H. and Gabbert, H.E. (2006) Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signalling. FEBS Journal, 273. pp. 4754-4769.

Milner, J.M., Kevorkian, L., Young, D.A., Jones, D., Wait, R., Donell, ST, Barksby, E., Patterson, A.M., Middleton, J., Cravatt, B.F., Clark, I.M., Rowan, A.D. and Cawston, T.E. (2006) Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis. Arthritis Research & Therapy, 8 (1). pp. 1186-1877.

Tuddenham, Lee, Wheeler, G., Ntouniafousara, S., Waters, J., Hajihosseini, Mohammad, Clark, Ian and Dalmay, Tamas (2006) The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Letters, 580 (17). pp. 4214-4217. ISSN 00145793

Porter, S., Clark, I.M., Kevorkian, L. and Edwards, D.R. (2005) The ADAMTS metalloproteinases. Biochemical Journal, 386. pp. 15-27.

Young, D.A., Billingham, O., Sampieri, C.L., Edwards, D.R. and Clark, I.M. (2005) Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta 1 induced murine tissue inhibitor of metalloproteinases-1 gene expression. FEBS Journal, 272. pp. 1912-1926.

Young, D.A., Lakey, R.L., Pennington, C.J., Jones, D., Kevorkian, L., Edwards, D.R., Cawston, T.E. and Clark, I.M. (2005) Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. Arthritis Research and Therapy, 7 (3). pp. 503-512. ISSN 1478-6354

Kevorkian, Lara, Young, D.A., Darrah, C., Donell, ST, Shepstone, Lee, Porter, S., Brockbank, S.M.V., Edwards, D.R., Parker, A.E. and Clark, I.M. (2004) Expression profiling of metalloproteinases and their inhibitors in cartilage. Arthritis and Rheumatism, 50 (1). pp. 131-141. ISSN 0004-3591

Young, D.A., Gavrilov, S., Pennington, C.J., Nuttall, R.K., Edwards, D.R., Kitsis, R.N. and Clark, I.M. (2004) Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes. Biochemical and Biophysical Research Communications, 322. pp. 759-765.

Hall, MC, Young, DA, Waters, JG, Rowan, AD, Chantry, A, Edwards, DR and Clark, IM (2003) The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. Journal of Biological Chemistry, 278 (12). pp. 10304-10313. ISSN 10304-10313

Clark, I.M. and Parker, A.E. (2003) Metalloproteinases: their role in arthritis and potential as therapeutic targets. Expert Opinion in Therapeutic Targets, 7. pp. 19-34.

Hall, M.C., Young, D.A., Rowan, A.D., Edwards, D.R. and Clark, I.M. (2002) Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors. Biotechniques, 33. pp. 1004-1008.

Koshy, P.J.T., Lundy, C.J., Rowan, A.D., Porter, S., Edwards, D.R., Hogan, A., Clark, I.M. and Cawston, T.E. (2002) The modulation of matrix metalloproteinase (MMP) and A Disintegrin And Metalloproteinase (ADAM) gene expression in human chondrocytes by interleukin-1 and oncostatin M. Arthritis and Rheumatism, 46. pp. 961-967.

Murphy, G., Knauper, K., Atkinson, S., Butler, G., English, W., Hutton, M., Stracke, J. and Clark, Ian (2002) Matrix metalloproteinases in arthritic disease. Arthritis Research and Therapy, 4. pp. 539-549.

Price, J.S., Waters, J.G., Darrah, C., Pennington, C., Edwards, D.R., Donell, S.T. and Clark, I.M. (2002) The role of chondrocyte senescence in osteoarthritis. Aging Cell, 1. pp. 57-65.

Young, D.A., Philllips, B.W., Lundy, C., Nutall, R.K., Hogan, A., Schultz, G.A., Leco, K.J., Clark, I.M. and Edwards, D.R. (2002) Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene. Biochemical Journal, 364. pp. 89-99.

Book Section

Wilkinson, JM, Jones, ER, Riley, GP, Chojnowski, AJ and Clark, IM (2012) The Expression of Collagen-Degrading Proteases Involved in Dupuytren’s Disease Fibroblast-Mediated Contraction. In: Dupuytren’s Disease and Related Hyperproliferative Disorders. UNSPECIFIED, pp. 143-149.

Rodgers, UR and Clark, IM (2010) Expression of Recombinant MMP-28 in Mammalian Cells. In: Matrix Metalloproteinase Protocols. UNSPECIFIED, pp. 55-65.

Clark, I.M. and Murphy, G. (2004) Matrix proteinases. In: UNSPECIFIED Academic Press.

Clark, I.M., Thomas, M.D. and de Vos, S. (2002) Plant matrixins. In: UNSPECIFIED Academic Press, pp. 570-572.

Monograph

Clark, IM, Macgregor, AJ and Donell, ST (2008) Editorial-The genetic association between asporin and osteoarthritis. Editorial. UNSPECIFIED.

Clark, I.M., Young, D.A. and Edwards, D.R. (2003) TIMP-1 enhancer sequence: real or bacterial. Letter to Editor. UNSPECIFIED.

Conference or Workshop Item

WIlliams, F, Davidson, R, Skinner, J, Culley, K, Bao, YP, Cassidy, A, Clark, I and Macgregor, A (2009) Epidemiological and Molecular Evidence for the Chondroprotective Effect of Garlic in Osteoarthritis. In: Annual Meeting of the British-Society-of-Rheumatology, April 28 - May 01 2009, Glasgow, Scotland.

Davidson, R., Donell, S., Darrah, C., Cooper, A. and Clark, Ian (2006) Controlling proteinase gene expression osteoarthritis. In: UNSPECIFIED.

Book

Clark, IM, Rowan, AD and Young, DA (2010) Matrix metalloproteinase protocols 2nd Edition. Medthods in Molecular Biology . Springer (Humana Press). ISBN 978-1-60327-298-8

Clark, I.M. (2001) Matrix Metalloproteinase Protocols. Humana Press, Totowa, New Jersey, USA.

Patent

418435.4 (2004) HDAC inhibitors and methods of use thereof. .