Dr Graham Riley
| Job Title | Contact | Location |
|---|---|---|
| Senior Research Fellow |
Graham dot Riley at uea dot ac dot uk
Tel: +44 (0)1603 59 3853 |
Biology 01.30 |
Career
- Arthritis Research UK Senior Research Fellow, University of East Anglia (2007-present)
- Head of Soft Tissue Injury and Repair Group, Rheumatology Research Unit (RRU) Addenbrooke’s Hospital, Cambridge (1996-2007)
- Post-doctoral Research Assistant, RRU, Addenbrooke’s Hospital, Cambridge (1993-1996)
- Research Assistant, RRU, Addenbrooke’s Hospital, Cambridge (1988-1993)
- PhD – RRU, Addenbrooke’s Hospital, Cambridge (1993)
- Research Assistant, Wellcome Laboratories, Beckenham, Kent (1987)
- Research Assistant, Leukaemia Research Fund Laboratories, London (1984-1986)
- Research Assistant, Pasteur Institute, Paris, France (1982-1984)
- BSc - Biochemistry, University of Bristol (1981)
ResearcherID
http://www.researcherid.com/rid/D-3809-2009Key Research Interests
Current Research Projects
- The role and function of MMP-23 in tendon, cartilage and other connective tissues
- The regulation of metalloproteinases in tendon cells by mechanical strain
- The role of mechanical strain in the development of tendon pathology
- The expression profile of enzymes in tendon pathology
- The role and regulation of enzymes in Dupuytren’s Disease
Life in our research group
We investigate a number of questions relating to the causes of tendon pain and rupture. We occupy space in the Biomedical Research Centre, a modern purpose-built research building that is well equipped for cell and molecular biology. The open-plan laboratory brings us into everyday contact with other researchers with similar interests. We are part of the Cellular Protease Group (CPG), which has a broad interest in the role of proteases in a variety of different diseases. We are also an integral part of the Musculoskeletal Research Group, which has research interests in cartilage, bone, tendon, ligament and fascia, all common sites of joint disease. We collaborate with scientists and clinicians in UEA and the Norfolk and Norwich University Hospital, as well as colleagues outside the Norwich Research Park. For example, we have a major and growing collaboration with a team of biomedical engineers from Queen Mary, University of London. Our work is funded by major charities, such as Arthritis Research UK and The Wellcome Trust, as well as local charities such as Action Arthritis. We have regular lab meetings, attend seminars, and engage with other scientists from a range of disciplines at national and international research meetings. In a typical year we will present our work at the biannual conferences of the British Society for Matrix Biology and the annual conference of the British Society for Rheumatology. Highlights in 2010 include participation in the American Orthopaedic Research Society meeting in New Orleans, and the Federation of European Connective Tissue Society’s (FECTS) meeting in Davos, Switzerland.PhD Positions
Please email me to discuss PhD opportunities and projects within the School of Biological Sciences.Postdocs & Fellows
I am always pleased to discuss possible research collaborations, grant applications and opportunities for graduate and postdoctoral appointments in my group. We can explore potential funding routes such as project grant applications and fellowships from bodies such as Arthritis Research UK, MRC, BBSRC, and the Wellcome Trust.Teaching Activities
- Investigation of Human Disease (2B30)
- Biomedicine (3C34)
- Mathematics and Statistics (1A6Y)
- Introductory Chemistry (1A61)
- Cell Biology (2B06)
- Cancer Biology (3C27)
- Skills for Biologists (1A4Y)
- Cell physiology (2B05)
- MSc in Medical Biotechnology (M105)
- Frontiers in molecular medicine (M201)
- Experimental techniques in molecular medicine (M203)
- Lectures to undergraduate Medicine (MBBS) students (MED) and postgraduate physiotherapists (AHP)
- Regular participation in MSc courses and graduate training programmes both within UEA and externally
Article
Corps, AN, Robinson, AHN, Harrall, RL, Avery, NC, Curry, VA, Hazleman, BL and Riley, GP (2012) Changes in matrix protein biochemistry and the expression of mRNA encoding matrix proteins and metalloproteinases in posterior tibialis tendinopathy. Annals of the Rheumatic Diseases. ISSN 0003-4967
Legerlotz, K, Jones, ER, Screen, HRC and Riley, GP (2012) Increased expression of IL-6 family members in tendon pathology. Rheumatology, Epub ahead of print. ISSN 1462-0324
Wilkinson, JM, Davidson, RK, Swingler, TE, Jones, ER, Corps, AN, Johnston, P, Riley, GP, Chojnowski, AJ and Clark, IM (2012) MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction. BBA - Biochimica et Biophysica Acta. (In Press)
Legerlotz, K, Jones, GC, Screen, HRC and Riley, GP (2011) Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes. Scandinavian Journal of Medicine & Science in Sports. n/a-n/a. ISSN 09057188
Legerlotz, K, Riley, GP and Screen, H (2010) Specimen dimensions influence the measurement of material properties in tendon fascicles. Journal of Biomechanics, 43 (12). pp. 2274-2280. ISSN 00219290
Corps, AN, Jones, GC, Harrall, RL, Curry, VA, Hazleman, BL and Riley, GP (2008) The Regulation of Aggrecanase ADAMTS-4 Expression in Human Achilles Tendon and tendon-Derived Cells. Matrix Biology, 27 (5). pp. 393-401.
Jones, GC, Riley, GP and Buttle, D (2008) The role of proteases in pathologies of the synovial joint. The International Journal of Biochemistry & Cell Biology, 40 (6-7). pp. 1199-1218. ISSN 13572725
Ljungqvist, A, Schwellnus, M, Bachl, N, Collins, M, Cook, J, Khan, K, Maffulli, N, Pitsiladis, Y, Riley, GP, Golspink, G, Venter, D, Derman, EW, Engebretsen, L and Volpi, P (2008) International Olympic Committee Consensus Statement: Molecular Basis of Connective Tissue and Muscle Injuries in Sport. Clinics in Sports Medicine, 27 (1). pp. 231-239. ISSN 02785919
Riley, G (2008) Tendinopathy—from basic science to treatment. Nature Clinical Practice Rheumatology, 4 (2). pp. 82-89. ISSN 1745-8382
Johnston, P, Chojnowski, A, Davidson, R, Riley, Graham, Donell, S and Clark, I (2007) A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease. The Journal of Hand Surgery, 32 (3). pp. 343-351. ISSN 03635023
Corps, AN, Robinson, AHN, Movin, T, Costa, ML, Hazleman, BL and Riley, GP (2006) Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy. Rheumatology, 45 (3). pp. 291-294. ISSN 1462-0324
Jones, GC, Corps, AN, Pennington, CJ, Clark, IM, Edwards, DR, Bradley, MM, Hazleman, BL and Riley, GP (2006) Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon. Arthritis & Rheumatism, 54 (3). pp. 832-842. ISSN 0004-3591
Riley, GP (2005) Gene expression and matrix turnover in overused and damaged tendons. Scandinavian Journal of Medicine and Science in Sports, 15 (4). pp. 241-251. ISSN 0905-7188
Jones, GC and Riley, GP (2005) ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. Arthritis Research and Therapy, 7 (4). pp. 160-169.
Riley, GP (2005) Chronic tendon pathology: molecular basis and therapeutic implications. Expert Reviews in Molecular Medicine, 7 (5). pp. 1-25. ISSN 1462-3994
Corps, A.N, Harrall, R.L, Curry, V.A, Hazleman, B.L and Riley, Graham (2005) Contrasting effects of fluoroquinolone antibiotics on the expression of the collagenases, matrix metalloproteinases (MMP)-1 and -13, in human tendon-derived cells. Rheumatology, 44 (12). pp. 1514-1517. ISSN 1462-0324
Corps, AN, Curry, VA, Buttle, DJ, Hazleman, BL and Riley, GP (2004) Inhibition of interleukin-1?-stimulated collagenase and stromelysin expression in human tendon fibroblasts by epigallocatechin gallate ester. Matrix Biology, 23 (3). pp. 163-169. ISSN 0945053X
Corps, AN, Robinson, AHN, Movin, T, Costa, ML, Ireland, DC, Hazleman, BL and Riley, GP (2004) Versican splice variant messenger RNA expression in normal human Achilles tendon and tendinopathies. Rheumatology, 43 (8). pp. 969-972. ISSN 1460-2172
Riley, GP (2003) The pathogenesis of tendinopathy. A molecular perspective. Rheumatology, 43 (2). pp. 131-142. ISSN 1460-2172
Corps, AN, Curry, VA, Harrall, RL, Dutt, D, Hazleman, BL and Riley, GP (2003) Ciprofloxacin reduces the stimulation of prostaglandin E2 output by interleukin-1 in human tendon-derived cells. Rheumatology, 42 (11). pp. 1306-1310. ISSN 1460-2172
Corps, AN, Harrall, RL, Curry, VA, Fenwick, SA, Hazleman, BL and Riley, GP (2002) Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1? in human tendon-derived cells. Arthritis & Rheumatism, 46 (11). pp. 3034-3040. ISSN 0004-3591
Fenwick, SA, Hazleman, BL and Riley, GP (2002) The vasculature and its role in the damaged and healing tendon. Arthritis Research, 4 (4). pp. 252-260.
Fenwick, SA, Curry, V, Harrall, RL, Hazleman, BL, Hackney, R and Riley, GP (2001) Expression of transforming growth factor-beta isoforms and their receptors in chronic tendinosis. Journal of Anatomy, 199 (3). pp. 231-240. ISSN 0021-8782
Ireland, D, Harrall, R, Curry, V, Holloway, G, Hackney, R, Hazleman, B and Riley, GP (2001) Multiple changes in gene expression in chronic human Achilles tendinopathy. Matrix Biology, 20 (3). pp. 159-169. ISSN 0945053X
Riley, GP, Cox, M, Harrall, RL, Clements, S and Hazleman, BL (2001) Inhibition of Tendon Cell Proliferation and Matrix Glycosaminoglycan Synthesis by Non-Steroidal Anti-Inflammatory Drugs in vitro. The Journal of Hand Surgery: Journal of the British Society for Surgery of the Hand, 26 (3). pp. 224-228. ISSN 02667681
Riley, GP, Goddard, MJ and Hazleman, BL (2001) Histopathological assessment and pathological significance of matrix degeneration in supraspinatus tendons. Rheumatology, 40 (2). pp. 229-230. ISSN 14602172
Roberts, PJ, Riley, GP, Morgan, K, Miller, R, Hunter, JO and Middleton, SJ (2001) The physiological expression of inducible nitric oxide synthase (iNOS) in the human colon. Journal of Clinical Pathology, 54 (4). pp. 293-297. ISSN 00219746
Legerlotz, K, Jones, E, Screen, H and Riley, GP Increased expression of IL6 family members in tendon pathology. Rheumatology.
Book Section
Wilkinson, JM, Jones, ER, Riley, GP, Chojnowski, AJ and Clark, IM (2012) The Expression of Collagen-Degrading Proteases Involved in Dupuytren’s Disease Fibroblast-Mediated Contraction. In: Dupuytren’s Disease and Related Hyperproliferative Disorders. UNSPECIFIED, pp. 143-149.
Riley, GP (2011) Tendons and ligaments. In: Rheumatology (5th Edition). Mosby Elsevier, Philadelphia, pp. 83-89. ISBN 978032306551
Riley, GP (2004) Tendon and ligament biochemistry and pathology. In: Soft tissue rheumatology. Oxford University Press, Oxford, pp. 20-53. ISBN 0192630938
Book
Hazleman, BL, Riley, GP and Speed, C (2004) Soft tissue rheumatology. Oxford University Press, Oxford. ISBN 0192630938
External Activities and Indicators of Esteem
- Organiser of symposium on tendon physiology and pathology – 2010, UEA
- Honorary Treasurer British Society for Matrix Biology (April 2004 – 2010)
- Consultant for Wyeth Laboratories, Cambridge, USA (2006-present)
- Member of International Olympic Committee Expert Panel on Molecular Basis of Connective Tissue and Muscle Injuries in Sport – February 2007, Lausanne, Switzerland
- Member of editorial board, Scandinavian Journal of Medicine and Science in Sports
- Organiser of research symposium ‘Tendon and ligament remodelling and regeneration’, 2006, Queens’ College, Cambridge
- Organiser of the British Society for Matrix Biology Spring Meeting 2006, Cambridge
- Member of Organising Committee XVIIIth Federation of European Connective Tissue Societies Meeting, Brighton, 2002 (600 attendees)
- Active member of American Orthopaedic Research Society – session moderator and reviewer of abstracts (2005 – present)
- Member, Development and Disease Theme Panel Biochemical Society, (2003–2006)
Administrative Posts/Responsibilities
- Chair of the BIO Ethical Review Committee since January 2010
- Plagiarism Officer for the School of Biological Sciences
- Module organiser, Modern Experimental Techniques in Molecular Medicine (M203)
