Dr Gary Rowley
| Job Title | Contact | Location |
|---|---|---|
| Lecturer in Bacterial Pathogenesis |
G dot Rowley at uea dot ac dot uk
Tel: 2889/1282 |
Biology 1.13 |
Career
- Lecturer, School of Biological Sciences, UEA (2007-)
- Postdoctoral Fellow, Institute of Food Research, UK (2004-2007)
- MRes & Ph.D. - University of Glasgow, UK (2000-2004)
- B.Sc. – Biomedical Science, University of Bradford, UK (1996-2000)
ResearcherID
http://www.researcherid.com/rid/F-7869-2011Key Research Interests
Current Research Projects
- Integration of envelope stress response pathways.
- The role of nitric oxide detoxification in physiology and pathogenesis.
- Identification of novel drug transport mechanisms.
- Nitrous oxide production by enteric and environmental bacteria (with Prof David Richardson)
- The role of chaperones in periplasmic homeostasis (with Dr Tom Clarke).
Life in our research group
Our research group uses a powerful combination of genetics, functional genomics, infection models and chemostat culture systems to understand the mechanisms that bacterial pathogens use to cause disease. We use the excellent facilities across the NRP such as the Wolfson Fermentation Laboratory and the brand new tissue culture facilities in the Biomedical research Centre. We are a new lab with lots of European flair and like to keep the fun in our science. We get together on a regular basis for lab meetings and journal presentations and we make sure that at least one group member goes to conferences relevant to our work. Group members recently presented at the American Society for Microbiology Salmonella Conference in Aix en Provence and we always make a regular appearance at Society for General Microbiology meetings in the UK. We are also committed to Science Outreach with lab members taking part in local science activities. We currently collaborate with several groups across the UK. If you think we can collaborate or help you in anyway please contact us.
PhD Positions
Please email me to discuss PhD opportunities and projects within the School of Biological Sciences.
Postdocs & Fellows
I am always happy to discuss possibilities for postdoctoral work and collaborations. Possible funding routes include applying for fellowships, e.g. EU Marie Curie or Royal Society fellowships, with me acting as sponsor, or grant applications with you as a named postdoc.Teaching Activities
- Skills for Biologists (BIO-1A4Y)
- Microbiology (BIO-2B28)
- Molecular Biology (BIO-2B02)
- Molecular Cell Biology (BIO-3C10)
- Microbial Biotechnology (BIO-3C09)
- Infection and Immunity (BIO-3C28)
- Medical Biotechnology (BIO-M105)
- Microbial and Enzyme Biotechnology (BIO-M101)
- Medical Biotechnology and Host:Pathogen Interactions (BIO-M207)
- Research Skills (BIO-M14Y)
- Research project (BIO-M13Y)
Article
Rowley, G, Hensen, D, Felgate, H, Arkenberg, A, Appia‑Ayme, C, Prior, K, Harrington, C, Field, SJ, Butt, JN, Baggs, E and Richardson, DJ (2012) Resolving the contributions of the membrane-bound and periplasmic nitrate reductase systems to nitric oxide and nitrous oxide production inSalmonella entericaserovar Typhimurium. Biochemical Journal, 441 (2). pp. 755-762. ISSN 0264-6021
Appia‑Ayme, C, Hall, A, Patrick, E, Rajadurai, S, Clarke, TA and Rowley, G (2012) ZraP is a periplasmic molecular chaperone and a repressor of the zinc-responsive two-component regulator ZraSR. Biochemical Journal, 442 (1). pp. 85-93. ISSN 0264-6021
Felgate, H, Giannopoulos, G, Sullivan, MJ, Gates, AJ, Clarke, T, Baggs, E, Rowley, G and Richardson, DJ (2012) The impact of copper, nitrate and carbon status on the emission of nitrous oxide by two species of bacteria with biochemically distinct denitrification pathways. Environmental Microbiology, 14 (7). pp. 1788-1800. ISSN 14622912
Arkenberg, A, Runkel, S, Richardson, DJ and Rowley, G (2011) The production and detoxification of a potent cytotoxin, nitric oxide, by pathogenic enteric bacteria. Biochemical Society Transactions, 39 (6). pp. 1876-1879. ISSN 0300-5127
Appia-Ayme, C, Patrick, EJ, Sullivan, M, Alston, MJ, Field, SJ, AbuOun, M, Anjum, MF and Rowley, G (2011) Novel Inducers of the Envelope Stress Response BaeSR in Salmonella Typhimurium: BaeR Is Critically Required for Tungstate Waste Disposal. PLoS ONE, 6 (8). e23713. ISSN 1932-6203
Rowley, G., Skovierova, H., Stevenson, A., Rezuchova, B., Homerova, D., Lewis, C., Sherry, A., Kormanec, J. and Roberts, M. (2011) The periplasmic chaperone Skp is required for successful Salmonella Typhimurium infection in a murine typhoid model. Microbiology, 157 (3). pp. 848-858. ISSN 1350-0872
Stremińska, MA, Felgate, H, Rowley, G, Richardson, DJ and Baggs, EM (2011) Nitrous oxide production in soil isolates of nitrate-ammonifying bacteria. Environmental Microbiology Reports. no-no. ISSN 17582229 (In Press)
Bowden, S.D., Rowley, G., Hinton, J.C. and Thompson, A. (2009) Glucose and glycolysis are required for the successful infection of macrophages and mice by Salmonella enterica serovar typhimurium. Infection and Immunity, 77(7). pp. 3117-3126.
Lewis, C., Skovierova, H., Rowley, G., Rezuchova, B., Homerova, D., Stevenson, A., Spencer, J., Farn, J., Kormanec, J. and Roberts, M. (2009) Salmonella enterican Serovar Typhimurium HtrA: regulation of expression and role of the chaperone and protease activities during infection. Microbiology, 155(Pt 3). pp. 873-881.
Prior, K., Hautefort, I., Hinton, J.C.D., Richardson, D.J. and Rowley, G. (2009) All Stressed Out. Salmonella Pathogenesis and Reactive Nitrogen Species. Advances in Microbial Physiology, 56. pp. 1-28. ISSN 00652911
Lewis, C., Skovierova, H., Rowley, G., Rezuchova, B., Homerova, D., Stevenson, A., Sherry, A., Kormanec, J. and Roberts, M. (2008) Small outer-membrane lipoprotein, SmpA, is regulated by oE and has a role in cell envelope integrity and virulence of Salmonella enterica serovar Typhimurium. Microbiology, 154. pp. 979-988.
Mills, P.C., Rowley, G., Spiro, S., Hinton, J.C.D. and Richardson, D.J. (2008) A combination of cytochrome c nitrite reductase (NrfA) and flavorubredoxin (NorV) protects Salmonella enterica serovar Typhimurium against killing by NO in anoxic environments. Microbiology, 154. pp. 1218-1228.
McMeehan, A., Roberts, M., Cogan, T.A., Jorgensen, F., Stevenson, A., Lewis, C, Rowley, G. and Humphrey, T.J. (2007) Role of the alternative sigma factors sigmaE and sigmaS in survival of Salmonella enterica serovar Typhimurium during starvation, refrigeration and osmotic shock. Microbiology, 153. pp. 263-269.
Balbontin, R., Rowley, G., Pucciarelli, M.G., Lopez-Garrido, J., Wormstone, Y., Lucchini, S., Garcia-Del Portillo, F., Hinton, J.C. and Casadesus, J. (2006) DNA adenine methylation regulates virulence gene expression in Salmonella enterica serovar Typhimurium. Journal of Bacteriology, 188 (23). pp. 8160-8168. ISSN 0021-9193
Lucchini, S., Rowley, G., Goldberg, M.D., Hurd, D., Harrison, M. and Hinton, J.C. (2006) H-NS mediates the silencing of laterally acquired genes in bacteria. PLoS Pathogens, 2 (8). pp. 746-752. ISSN 1553-7366
Rowley, G., Spector, M., Kormanec, J. and Roberts, M. (2006) Pushing the envelope: extracytoplasmic stress responses in bacterial pathogens. Nature Reviews Microbiology, 4. pp. 383-394.
Skovierova, H., Rowley, G., Rezuchova, B., Homerova, D., Lewis, C., Roberts, M. and Kormanec, J. (2006) Identification of the E regulon of Salmonella enterica serovar Typhimurium. Microbiology, 152 (5). pp. 1347-1359. ISSN 1350-0872
Thompson, A., Rowley, G., Alston, M., Danino, V. and Hinton, J.C. (2006) Salmonella transcriptomics: relating regulons, stimulons and regulatory networks to the process of infection. Current Opinion in Microbiology, 9. pp. 109-116.
Rowley, G., Stevenson, A., Kormanec, J. and Roberts, M. (2005) Effect of inactivation of degS on Salmonella enterica serovar Typhimurium in vitro and in vivo. Infection and Immunity, 73 (1). pp. 459-463. ISSN 0019-9567
Humphreys, S., Rowley, G., Stevenson, A., Anjum, M.F., Woodward, M.J., Gilbert, S., Kormanec, J. and Roberts, M. (2004) Role of the two-component regulatory CpxAR in the virulence of Salmonella enterica serotype Typhimurium. Infection and Immunity, 72. pp. 4654-4661.
Humphreys, S., Rowley, G., Stevenson, A., Kenyon, W.J., Spector, M.P. and Roberts, M. (2003) Role of periplasmic peptidylprolyl isomerases in Salmonella enterica serovar Typhimurium virulence. Infection and Immunity, 72. pp. 5386-5388.
Miticka, H., Rowley, G., Rezuchova, B., Homerova, D., Humphreys, S., Farn, J., Roberts, M. and Kormanec, J. (2003) Transcriptional analysis of the rpoE gene encoding extracytoplasmic stress response sigma factor sigmaE in Salmonella enterica serovar Typhimurium. FEMS Microbiology Letters, 226. pp. 307-314.
External Activities and Indicators of Esteem
- Council member of the Society of General Microbiology (2008-2012).
- Member of the American Society of Microbiology, the European Society of Clinical Microbiology and Infectious Disease and the Institute of Biology.
- Invited Speaker at NO: From Marvel to Menace, EuroSciCon, 2009.
Administrative Posts/Responsibilities
- Director of Postgraduate Teaching (BIO).
- Deputy Director of Teaching (BIO).
- Director of the Wolfson Fermentation Suite.
- Course Director for the MSc in Biotechnology for a Sustainable future.
- Module organiser for Infection and Immunity (BIO-3C28)
- Module organiser for Medical Biotechnology (BIO-M105)
- Module organiser for Medical Biotechnology and Host:Pathogen Interactions (BIO-M207)
- Module organiser for Research Skills (BIO-M14Y)
- Module organiser for Research Project (BIO-M13Y).


