Dr Gabriella Kelemen
| Job Title | Contact | Location |
|---|---|---|
| Lecturer |
G dot Kelemen at uea dot ac dot uk
Tel: 3288/1740 |
Biology 1.14 |
Career
- Lecturer, University of East Anglia (2000-present)
- Post Doctoral Fellow, John Innes Centre (1993-2000)
- Post Doctoral Fellow, University of Leicester (1991-1993)
- Leverhulme Trust Fellowship, University of Leicester, Department of Biochemistry (1989-1990)
- Ph.D. - Eötvös Loránd University Budapest, Hungary (1987)
- B.Sc. - Chemistry; Eötvös Loránd University Budapest, Hungary (1984)
ResearcherID
http://www.researcherid.com/rid/G-8486-2011MSc (Master of Science) training by research is available in my laboratory starting October 2012. Click here for further details.
Key Research Interests
Current Research Projects
- Bacterial polarised growth and its control by cytoskeletal proteins
- Chromosome organisation during hyphal growth
- Signalling in bacterial development
- The role of specific RNA polymerase holoenzymes controlling development and stress response
- Global characterisation of spore maturation and germination
MSc (Master of Science) training by research is available in my laboratory starting October 2012. Click here for further details.
Life in our Research Group
Our laboratory focuses on the biology of the model organism for bacterial development and antibiotic production, Streptomyces coelicolor. This exciting bacterium forms long, multigenomic filaments with complex branching patterns and at the end of its life cycle generates unigenomic spores ready for dispersal. Importantly, streptomycetes are the producers of more than 2/3 of the commercially available antibiotics. We are studying the mechanism of regulation of the complex developmental cycle of Streptomyces, including studies on gene expression, intra- and intercellular signalling and bacterial cytoskeletal proteins controlling cell shape and cell cycle using molecular biology, biochemistry and cell biology techniques. For localisation studies we access the Henry Wellcome Imaging laboratory for “state of the art” microscopy technologies. We have lab meetings and departmental seminars where we discuss experimental progress and recent publications. To present our results we regularly attend national and international conferences, such as the Society of General Microbiology meetings, the International Symposium on the Biology of Actinomycetes and Meetings on Bacterial Development.PhD Positions
We are seeking applicants fot a PhD Studentship on “Dissecting a bacterial polar assembly,” see http://ueasciweb.uea.ac.uk/Resproject/show.aspx?ID=86 Please contact me for any further information on this project.In addition, I would be happy to discuss externally funded PhD opportunities and projects within the School of Biological Sciences.
Postdocs & Fellows
I am always happy to discuss possibilities for postdoctoral work and collaborations. Possible funding routes include fellowship appliactions, e.g. EU Marie Curie fellowships, with me acting as sponsor, or grant applications with you as a named postdoc.Teaching Activities
- Molecular Biology (2B02)
- Microbiology (2B28)
- Microbial Cell Biology (3C10)
- Mathematics and Statistics for Biologists (1A6Y)
- Fundamentals of Cell Biology and Biochemistry (1A14)
Article
Walshaw, J, Gillespie, MD and Kelemen, GH (2010) A novel coiled-coil repeat variant in a class of bacterial cytoskeletal proteins. Journal of Structural Biology, 170 (2). pp. 202-215. ISSN 10478477
Gaskell, A, Crack, J, Cheeseman, MR, Kelemen, G, Hutchings, MI and Le Brun, N (2007) RsmA, an anti-sigma factor from Streptomyces coelicolor, modulates its activity through a [2Fe-2s] cluster cofactor. Journal of Biological Chemistry, 282 (43). pp. 31812-31820. ISSN 0021-9258
Dalton, KA, Thibessard, A, Hunter, JI and Kelemen, GH (2007) A novel compartment, the 'subqpical stem' of the aerial hyphae, is the location of a sigN-dependent, developmentally distinct transcription in Streptomyces coelicolor. Molecular Microbiology, 64 (3). pp. 719-737.
Hunt, AC, Servin-Gonzalez, L, Kelemen, GH and Buttner, MJ (2005) The bldC developmental locus of Streptomyces coelicolor encodes a member of a family of small DNA-binding proteins related to the DNA-binding domains of the MerR family. Journal of Bacteriology, 187 (2). pp. 716-728.
Traag, BA, Kelemen, GH and van Wezel, GP (2004) Transcription of the sporulation gene ssgA is activated by the IcIR-type regulator SsgR in a whi-independent manner in Streptomyces coelicolor A3(2). Molecular Microbiology, 53 (3). pp. 985-1000. ISSN 0950-382X
Viollier, PH, Kelemen, GH, Dale, GE, Nguyen, KT, Buttner, MJ and Thompson, CJ (2003) Specialized osmotic stress response systems involve multiple SigB-like sigma factors in Streptomyces coelicolor. Molecular Microbiology, 47 (3). pp. 699-714.
Kelemen, GH, Viollier, PH, Tenor, J, Marri, L, Buttner, MJ and Thompson, CJ (2001) A connection between stress and development in the multicelular prokaryote Streptomyces coelicolor. Molecular Microbiology, 40 (4). pp. 804-814. ISSN 0950-382X
Conference or Workshop Item
Leggett, RM, Grandison, S, Morris, RM, Kelemen, G and Moulton, V (2009) Statistical analysis of the growth and morphology of the filamentous microbe Streptomyces coelicolor. In: Statistical Tools for Challenges in Bioinformatics, 7th-9th July 2009, Leeds, UK.
External Activities and Indicators of Esteem
- Invited speaker: ISBA 14, International Symposium on the Biology of Actinomycetes “ A novel compartment in Streptomyces”, 2007
- Invited speaker : SGM Symposium : “ Distinct “tissues” in the mycelial bacterium, Streptomyces coelicolor, 2008
- Invited speaker: Frontiers of prokaryotic cell biology –EMBO, 2009
Administrative Posts/Responsibilities
- Course Director for Molecular Biology and Genetics and Genetics
- Module Organiser for Molecular Biology (2B02; 2003-present)
- University and School of Biology Microbiology Safety Officer
- Research Staff Coordinator/ Research Staff steering Committee
- Member of the Exam Board
- Deputy Theme leader for the Molecules and Pathways Theme
