Article

Baren, JP, Stewart, GD, Stokes, A, Gray, K, Pennington, CJ, O'Neill, R, Deans, DAC, Paterson-Brown, S, Riddick, ACP, Edwards, DR, Fearon, KCH, Ross, JA and Skipworth, RJE (2012) mRNA profiling of the cancer degradome in oesophago–gastric adenocarcinoma. British Journal of Cancer, 107 (1). pp. 143-149. ISSN 0007-0920

Charron, G, Stuchinskaya, T, Edwards, DR, Russell, DA and Nann, T (2012) Insights into the Mechanism of Quantum Dot-Sensitized Singlet Oxygen Production for Photodynamic Therapy. The Journal of Physical Chemistry C, 116 (16). pp. 9334-9342. ISSN 1932-7447

Eldred, JA, Hodgkinson, LM, Dawes, LJ, Reddan, JR, Edwards, DR and Wormstone, IM (2012) MMP2 Activity is Critical for TGF 2-Induced Matrix Contraction--Implications for Fibrosis. Investigative Ophthalmology & Visual Science, 53 (7). pp. 4085-4098. ISSN 0146-0404

Hahne, JC, Fuchs, T, Florin, A, Edwards, DR, Pourtier, A, Soncin, F and Wernert, N (2011) Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts. International Journal of Oncology, 39 (5). pp. 1073-1082. ISSN 1019-6439

Decock, J, Thirkettle, S, Wagstaff, L and Edwards, DR (2011) Matrix metalloproteinases: protective roles in cancer. Journal of Cellular and Molecular Medicine, 15 (6). pp. 1254-1265. ISSN 15821838

Elkington, P, Shiomi, T, Breen, R, Nuttall, RK, Ugarte-Gil, CA, Walker, NF, Saraiva, L, Pedersen, B, Mauri, F, Lipman, M, Edwards, DR, Robertson, BD, D’Armiento, J and Friedland, JS (2011) MMP-1 drives immunopathology in human tuberculosis and transgenic mice. Journal of Clinical Investigation, 121 (5). pp. 1827-1833. ISSN 0021-9738

Ramsay, AK, McCracken, SRC, Soofi, M, Fleming, J, Yu, AX, Ahmad, I, Morland, R, Machesky, L, Nixon, C, Edwards, DR, Nuttall, RR, Seywright, M, Marquez, R, Keller, E and Leung, HY (2011) ERK5 signalling in prostate cancer promotes an invasive phenotype. British Journal of Cancer, 104 (4). pp. 664-672. ISSN 0007-0920

Wagstaff, L, Kelwick, R, Decock, J and Edwards, DR (2011) The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis. Frontiers in Bioscience, 16 (1). pp. 1861-1872. ISSN 10939946

Stuchinskaya, T, Moreno, M, Cook, MJ, Edwards, DR and Russell, DA (2011) Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates. Photochemical & Photobiological Sciences, 10 (5). pp. 822-831. ISSN 1474-905X

Hodgkinson, LM, Wang, L, Duncan, G, Edwards, DR and Wormstone, IM (2010) ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells. Molecular Vision, 16. pp. 2765-2776.

Ravenhill, L, Wagstaff, L, Edwards, DR, Ellis, V and Bass, R (2010) G-helix of Maspin Mediates Effects on Cell Migration and Adhesion. Journal of Biological Chemistry, 285 (47). pp. 36285-36292. ISSN 0021-9258

Cooley, LS, Handsley, MM, Zhou, Z, Lafleur, MA, Pennington, CJ, Thompson, EW, Poschl, E and Edwards, DR (2010) Reversible trans-differentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro. Journal of Cell Science, 123 (21). pp. 3808-3816. ISSN 0021-9533

Atkinson, J.M., Falconer, R.A., Edwards, D.R., Pennington, C.J., Siller, C.S., Shnyder, S.D., Bibby, M.C., Patterson, L.H., Loadman, P.M. and Gill, J.H. (2010) Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases. Cancer Research, 70 (17). pp. 6902-6912. ISSN 0008-5472

Barter, MJ, Pybus, L, Litherland, GJ, Rowan, AD, Clark, IM, Edwards, DR, Cawston, TE and Young, DA (2010) HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes. Matrix Biology, 29 (7). pp. 602-612. ISSN 0945053X

Bass, Rosemary and Edwards, D.R. (2010) ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding? Biochemical Journal, 428 (3). e3-e5. ISSN 0264-6021

Green, J.A., Elkington, P T., Pennington, C.J., Roncaroli, F., Dholakia, S., Moores, R.C., Bullen, A., Porter, J.C., Agranoff, D., Edwards, D.R. and Friedland, J.S. (2010) Mycobacterium tuberculosis Upregulates Microglial Matrix Metalloproteinase-1 and -3 Expression and Secretion via NF- B- and Activator Protein-1-Dependent Monocyte Networks. The Journal of Immunology, 184 (11). pp. 6492-6503. ISSN 0022-1767

Krüger, Achim, Kates, Ronald E. and Edwards, Dylan (2010) Avoiding spam in the proteolytic internet: Future strategies for anti-metastatic MMP inhibition. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1803 (1). pp. 95-102. ISSN 01674889

Lee, Meng-Huee, Atkinson, Susan, Rapti, Magdalini, Handsley, Madeleine, Curry, Valerie, Edwards, Dylan and Murphy, Gillian (2010) The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment. Cancer Letters, 290 (1). pp. 114-122. ISSN 03043835

Pennington, Caroline J. and Edwards, Dylan (2010) Real-Time PCR Expression Profiling of MMPs and TIMPs. Methods in Molecular Biology, 622. pp. 159-173. ISSN 1064-3745

Stokes, A., Joutsa, J., Ala-aho, R., Pitchers, M., Pennington, C. J., Martin, C., Premachandra, D. J., Okada, Y., Peltonen, J., Grenman, R., James, H. A., Edwards, D. R. and Kahari, V. M. (2010) Expression Profiles and Clinical Correlations of Degradome Components in the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research, 16 (7). pp. 2022-2035. ISSN 1078-0432

Boutet, P., Aguera-Gonzalez, S., Atkinson, S., Pennington, C.J., Edwards, D.R., Murphy, G., Reyburn, H.T. and Vales-Gomez, M. (2009) Cutting edge: The metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein. Journal of Immunology, 182. pp. 49-53.

Frutkin, A.D., Otsuka, G., Stempien-Otero, A., Sesti, C., Du, L., Jaffe, M., Dichek, H.L., Pennington, C.J., Edwards, Dylan, Nieves-Cintron, M., Minter, D., Preusch, M., Hu, J.H., Marie, J.C. and Dichek, D.A. (2009) TGF- 1 Limits Plaque Growth, Stabilizes Plaque Structure, and Prevents Aortic Dilation in Apolipoprotein E-Null Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 29 (9). pp. 1251-1257. ISSN 1079-5642

Hancox, R.A., Allen, M.D., Holliday, D.L., Edwards, D.R., Pennington, C.J., Shaw, J.A., Walker, R.A., Pringle, J.H. and Jones, J.L. (2009) Tumor-associated Tenascin-C isoforms promote breast cancer cell invasion and growth by MMP-dependent and independent mechanisms. Breast Cancer Research, 11. p. 24.

Harvey, Amanda J., Pennington, Caroline J., Porter, Sarah, Burmi, Rajpal S., Edwards, Dylan, Court, William, Eccles, Suzanne A. and Crompton, Mark R. (2009) Brk Protects Breast Cancer Cells from Autophagic Cell Death Induced by Loss of Anchorage. The American Journal of Pathology, 175 (3). pp. 1226-1234. ISSN 00029440

Maretzky, T., Le Gall, S.M., Worpenberg, S., Eder, J., Overall, C., Huang, X-Y., Poghosyan, Z., Edwards, D.R. and Blobel, C.P. (2009) Src stimulates FGFR2 shedding by an ADAM15 splice variant linked to breast cancer. Cancer Research, 69. pp. 4573-4576.

Edwards, DR, Handsley, M and Pennington, CJ (2008) The ADAM Metalloproteinases. Molecular Aspects of Medicine, 29 (5). pp. 258-289.

Clark, IM, Swingler, TE, Sampieri Ramirez, CL and Edwards, DR (2008) The regulation of matrix metalloproteinases and their inhibitors. The International Journal of Biochemistry & Cell Biology, 40 (6-7). pp. 1362-1378. ISSN 13572725

Gutierrez-Fernandez, A, Fueyo, A, Folgueras, AR, Garabaya, C, Pennington, CJ, Pilgrim, S, Edwards, DR, Holliday, DL, Jones, JL, Span, PN, Sweep, FCGJ, Puente, XS and Lopez-Otin, C (2008) Matrix Metalloproteinase-8 functions as a metastasis suppressor through modulation of tumour cell adhesion and invasion. Cancer Research, 68. pp. 2755-2763.

Folgueras, AR, Fueyo, A, Garcia-Suarez, O, Cox, J, Astudillo, A, Tortorella, P, Campestre, C, Gutierrez-Fernandez, A, Fanjul-Fernandez, M, Pennington, CJ, Edwards, DR, Overall, CM and Lopez-Otin, C (2008) Collagenase-2 Deficiency or Inhibition Impairs Experimental Autoimmune Encephalomyelitis in Mice. Journal of Biological Chemistry, 283 (14). pp. 9465-9474. ISSN 0021-9258

Gerg, M, Kopitz, C, Schaten, S, Tschukes, A, Kahlert, C, Stangl, M, von Weyhern, CWH, Brucher, BLDM, Edwards, DR, Brand, K and Kruger, A (2008) Distinct functionality of tumour cell-derived gelatinases during formation of liver metastases. Molecular Cancer Research, 6. pp. 341-351.

Nielsen, B.S., Egeblad, M., Rank, F., Askautrud, H.A., Pennington, C.J., Pedersen, T.X., Christensen, I.J., Edwards, D.R., Web, Z. and Lund, L.R. (2008) Matrix Metalloproteinase 13 Is Induced in Fibroblasts in Polyomavirus Middle T Antigen-Driven Mammary Carcinoma without Influencing Tumor Progression. PLoS One, 3(8). p. 2959.

Oddsdottir, C., Riley, S.C., Leask, R., Edwards, D.R. and Watson, E.D. (2008) Activities of matrix metalloproteinases-9 and -2 in uterine fluid during induced equine endometritis. Pferdeheilkunde, 24. pp. 70-73.

Sampieri, C.L., Nuttall, R.K., Young, D.A., Goldspink, D., Clark, I.M. and Edwards, D.R. (2008) Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes. Matrix Biology, 27. pp. 128-138.

Shukla, C.J., Pennington, C.J., Riddick, A.C.P., Sethia, K.K., Ball, R.Y. and Edwards, D.R. (2008) Laser capture microdissection in prostate cancer research: establishment and validation of a powerful tool for the assessment of tumour-stroma interactions. British Journal of Urology, 101. pp. 765-774.

Stewart, G.D., Gray, K., Pennington, C.J., Edwards, D.R., Riddick, A.C., Ross, J.A. and Habib, F.K. (2008) Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason score. Oncology Reports, 20. pp. 1561-1567.

Stewart, G.D., Skipworth, R.J., Pennington, C.J., Lowrie, A.G., Deans, D.A., Edwards, D.R., Habib, F.K., Riddick, A.C., Fearon, K.C. and Ross, J.A. (2008) Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines. British Journal of Cancer, 99. pp. 126-132.

Zhong, J.L., Poghosyan, Z., Pennington, C.J., Scott, X., Handsley, M.M., Warn, A., Gavrilovic, J., Honert, K., Kruger, A., Span, P.N., Sweep, F.C.G.J. and Edwards, D.R. (2008) Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. Molecular Cancer Research, 6. pp. 383-394.

Atkinson, J.M., Pennington, C.J., Martin, S.W., Anikin, V.A., Mearns, A.J., Loadman, P.M., Edwards, D.R. and Gill, J.H. (2007) Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: Correlation of MMP-14 mRNA expression and proteolytic activity. European Journal of Cancer, 43. pp. 1764-1771.

Harris, J.E., Nuttall, R.K., Elkington, P.T., Green, J.A., Horncastle, D.E., Graeber, M.B., Edwards, D.R. and Friedland, J.S. (2007) Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo. Journal of Immunology, 178. pp. 1199-1207.

Hodgkinson, L.M., Duncan, G., Wang, L., Pennington, C.J., Edwards, D.R. and Wormstone, I.M. (2007) MMP and TIMP expression in quiescent, dividing and differentiating human lens cells. Investigative Ophthalmology and Visual Science, 48. pp. 4192-4199.

Kopitz, C., Ister, D., Gerg, M., Pennington, C.J., Wei, S., Hauser, S., Krell, H-W., Nagase, H., Brew, K., Edwards, D.R. and Kruger, A. (2007) Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling. Cancer Research, 67. pp. 8615-8623.

Nuttall, R.K., Silva, C., Hader, W., Bar-Or, A., Patel, K.D., Edwards, D.R. and Yong, V.W. (2007) Metalloproteinases MMPs amd ADAMs) are enriched in microglia compared to leukocytes and they regulate cytokine levels in activated microglia. Glia, 55. pp. 516-526.

Rooprai, H.K., Kyriazis, I., Nuttall, R.K., Edwards, D.R., Zicha, D., Aubyn, D., Davies, D., Gullan, R. and Pilkington, G.J. (2007) Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. International Journal of Oncology, 30. pp. 1263-1271.

Jones, GC, Corps, AN, Pennington, CJ, Clark, IM, Edwards, DR, Bradley, MM, Hazleman, BL and Riley, GP (2006) Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon. Arthritis & Rheumatism, 54 (3). pp. 832-842. ISSN 0004-3591

Chabottaux, V., Sounni, N.E., Pennington, C.J., English, W.R., van den Brule, F., Blacher, S., Gilles, C., Munaut, C., Maquoi, E., Lopez-Otin, C., Murphy, g., Edwards, D.R., Foidart, J.M. and Noel, A. (2006) Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases. Cancer Research, 66. pp. 5165-5172.

Dalmay, T. and Edwards, D.R. (2006) MicroRNAs and the Hallmarks of Cancer. Oncogene, 25. pp. 6170-6175.

Garcia-Alvarez, J., Ramirex, R., Checa, M., Nuttall, R.K., Sampieri, C.L., Edwards, D.R., Selman, M. and Pardo, A. (2006) Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis. Experimental Lung Research, 32. pp. 201-214.

Garcia-Alvarez, J., Ramirez, R., Sampieri, C.L., Nuttall, R.K., Edwards, D.R., Selman, M. and Pardo, A. (2006) Membrane type-matrix metalloproteinases in idiopathic pulmonary fibrosis. Sarcoidosis Vasculitis and Diffuse Lung Diseases, 23. pp. 13-21.

Pitchers, M., Stockes, A., Lonsdale, R., Premachandra, D.J. and Edwards, D.R. (2006) Research tissue banking in otolaryngology: organization, methods and uses, with reference to practical, ethical and legal issues. Journal of Laryngology and Otology, 120. pp. 433-438.

Porter, S., Span, P.N., Sweep, F.C.G.J., Tjan-Heijnen, V.C.G., Pennington, C.J., Pedersen, T.X., Johnsen, M., Lund, L.R., Romer, J. and Edwards, D.R. (2006) ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma. International Journal of Cancer, 118. pp. 1241-1247.

Sarkar, S., Nuttall, R.K., Liu, S., Edwards, D.R. and Yong, V.W. (2006) Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12. Cancer Research, 66. pp. 11771-11780.

Wallard, M.J., Pennington, C.J., Veerakumarasivam, A., Burtt, G., Mills, I.G., Warren, A., Leung, H.Y., Murphy, G., Edwards, D.R., Neal, D.E. and Kelly, J.D. (2006) Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma. British Journal of Cancer, 94. pp. 569-577.

Denton, C.P., Lindahl, G.E., Khan, K., Xu, SW., Ong, V.H., Gaspar, N.J., Lazaridis, K., Edwards, D.R., Leask, A., Eastwood, M., Leoni, P., Renzoni, E.A., Gharios, G.B., Abraham, D.J. and Black, C.M. (2005) Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II transforming growth factor-beta receptor (T beta RII Delta k). Journal of Biological Chemistry, 280. pp. 16053-16065.

Elkington, P.T.G., Nuttall, R.K., Boyle, J.J., O'Kane, C.M., Horncastle, D., Edwards, D.R. and Friedland, J.S. (2005) Profile and regulation of matrix metalloproteinase gene expression and secretion in human tuberculosis is divergent from Mycobacterium bovis BCG vaccine strain. American Journal of Respiratory and Critical Care Medicine, 172. pp. 1596-1604.

Handsley, M.M. and Edwards, D.R. (2005) Metalloproteinases and their inhibitors in tumour angiogenesis. International Journal of Cancer, 115. pp. 849-860.

Kassiri, Z., Oudit, G.Y., Mohammed, F.F., Sanchez, O., Dawood, F., Nuttall, R.K., Edwards, D.R., Backx, P.H., Liu, P. and Khokha, R. (2005) Combination of TNFalpha Ablation and MMP Inhibition Prevents Heart Failure After Pressure Overload in TIMP-3 Mutant Mice. Circulation Research, 97. pp. 380-390.

Mohammed, F.F., Pennington, C.J., Kassiri, Z., Rubin, J.S., Soloway, P.D., Ruther, U., Edwards, D.R. and Khokha, R. (2005) Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology, 41. pp. 857-867.

Pedersen, T.X., Pennington, C.J., Almhold, K., Christensen, I.J., Nielsen, B.S., Edwards, D.R., Romer, J., Dano, K. and Johnsen, M. (2005) Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas. Carcinogenesis, 26. pp. 1233-1240.

Porter, S., Clark, I.M., Kevorkian, L. and Edwards, D.R. (2005) The ADAMTS metalloproteinases. Biochemical Journal, 386. pp. 15-27.

Riddick, A.C., Shukla, C.J., Pennington, C.J., Bass, R., Nuttall, R.K., Hogan, A., Sethia, K.K., Ellis, V., Collins, A.T., Maitland, N.J., Ball, R.Y. and Edwards, D.R. (2005) Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues. British Journal of Cancer, 92 (12). pp. 2171-2180. ISSN 0007-0920

Singh, R.J., Mason, J.C., Lidington, E.A., Edwards, D.R., Nuttall, R.K., Khokha, R., Knauper, V., Murphy, G. and Gavrilovic, J. (2005) Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovascular Research, 67 (1). pp. 39-49. ISSN 0008-6363

Weaver, A., Goncalves da Silva, A., Nuttall, R.K., Edwards, D.R., Shapiro, S.D., Rivest, S. and Young, V.W. (2005) An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization. FASEB Journal, 19. pp. 1668-1670.

Young, D.A., Billingham, O., Sampieri, C.L., Edwards, D.R. and Clark, I.M. (2005) Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta 1 induced murine tissue inhibitor of metalloproteinases-1 gene expression. FEBS Journal, 272. pp. 1912-1926.

Young, D.A., Lakey, R.L., Pennington, C.J., Jones, D., Kevorkian, L., Edwards, D.R., Cawston, T.E. and Clark, I.M. (2005) Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. Arthritis Research and Therapy, 7 (3). pp. 503-512. ISSN 1478-6354

Bevan, D., Gherardi, E., Fan, T.P., Edwards, D.R. and Warn, R. (2004) Diverse and potent activities of HGF/SF in skin wound repair. Journal of Pathology, 203. pp. 831-838.

Edwards, D.R. (2004) TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges. Journal of Pathology, 202. pp. 391-394.

Kevorkian, Lara, Young, D.A., Darrah, C., Donell, ST, Shepstone, Lee, Porter, S., Brockbank, S.M.V., Edwards, D.R., Parker, A.E. and Clark, I.M. (2004) Expression profiling of metalloproteinases and their inhibitors in cartilage. Arthritis and Rheumatism, 50 (1). pp. 131-141. ISSN 0004-3591

Nuttall, R.K., Sampieri, C.L., Pennington, C.J., Gill, S.E., Schultz, G.A. and Edwards, D.R. (2004) Expression analysis of the entire MMP and TIMP gene families during mouse tissue development. FEBS Letters, 563. pp. 129-134.

Porter, S., Scott, S.D., Sassoon, E.M., Williams, M.R., Jones, J.L., Girling, A.C., Ball, R.Y. and Edwards, D.R. (2004) Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma. Clinical Cancer Research, 10 (7). pp. 2429-2440. ISSN 1078-0432

Toft-Hansen, H., Nuttall, R.K., Edwards, D.R. and Owens, T. (2004) Key metalloproteinases are expressed by specific cell types in experimental autoimune encephalomyelitis. Journal of Immunology, 173. pp. 5209-5218.

Young, D.A., Gavrilov, S., Pennington, C.J., Nuttall, R.K., Edwards, D.R., Kitsis, R.N. and Clark, I.M. (2004) Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes. Biochemical and Biophysical Research Communications, 322. pp. 759-765.

Hall, MC, Young, DA, Waters, JG, Rowan, AD, Chantry, A, Edwards, DR and Clark, IM (2003) The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. Journal of Biological Chemistry, 278 (12). pp. 10304-10313. ISSN 10304-10313

Alter, A., Duddy, M., Hebert, S., Biernacki, K., Prat, A., Antel, J.P., Yong, V.W., Nuttall, R.K., Pennington, C.J., Edwards, D.R. and Bar-Or, A. (2003) Determinants of human B cell migration across brain endothelial cells. Journal of Immunology, 170. pp. 4497-4505.

Banke, I.J., Arlt, M.J.E., Pennington, C., Kopitz, C., Steinmetzer, T., Schweinitz, A., Gasbacher, B., Quigley, J.P., Edwards, D.R., Sturzebecher, J. and Kruger, A. (2003) Increase of Anti-Metastatic Efficacy by Selectivity- but not Affinity-Optimization of Synthetic Serine Protease Inhibitors. Biological Chemistry, 384. pp. 1515-1525.

Bar-Or, A., Nuttall, R., Duddy, M., Alter, A., Pennington, C.J., Bourgoin, P., Edwards, D.R. and Yong, V.W. (2003) Analyses of all MMP members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain, 126. pp. 2738-2749.

Lafleur, M.A., Handsley, M.M. and Edwards, D.R. (2003) Metalloproteinases and their inhibitors in angiogenesis. Expert Reviews in Molecular Medicine, 5. pp. 1-39.

Moorehead, R.A., Hojilla, C.V., De Belle, I., Wood, G.A., Fata, J.E., Adamson, E.D., Watson, K.L., Edwards, D.R. and Khokha, R. (2003) IGF-II regulates PTEN expression in the mammary gland. Journal of Biological Chemistry, 278. pp. 50422-50427.

Nuttall, R.K., Pennington, C.J., Taplin, J., Wheal, A., Yong, V.W., Forsyth, P.A. and Edwards, D.R. (2003) Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells. Molecular Cancer Research, 1 (5). pp. 333-345. ISSN 1541-7786

Palosaari, H., Pennington, C.J., Larmas, M., Edwards, D.R., Tjaderhane, L. and Salo, T. (2003) Expression profile of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in mature human odontoblasts and pulp tissue. European Journal of Oral Sciences, 111. pp. 117-127.

Pardo, A., Garcia-Alvarez, J., Ramirez, R., Nuttall, R., Pennington, C., Edwards, D. and Selman, M. (2003) Lung expression of membrane-type matrix metalloproteinases (MT-MMPs) in idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP). FASEB Journal, 17. p. 832.

Platt, C., Krekoski, C.A., Edwards, D.R. and Gavrilovic, J. (2003) Extracellular matrix and matrix metalloproteinases in sciatic nerve. Journal of Neuroscience Research, 74 (3). pp. 417-429. ISSN 0360-4012

Riddick, A.C.P., Barker, C., Sheriffs, I., Bass, R., Ellis, V., Sethia, K.K., Edwards, D.R. and Ball, R.Y. (2003) Banking of fresh frozen prostate tissue: methods, validation and use. British Journal of Urology Internation, 91. pp. 315-323.

Wells, J.E., Rice, T., Nuttall, R.K., Edwards, D.R., Zekki, H., Rivest, S. and Yong, V.W. (2003) An adverse role for matrix metalloproteinase (MMP)-12 following spinal cord injury in mice. Journal of Neuroscience Research, 23. pp. 10107-10115.

Worley, J.R., Baugh, M.D., Hughes, D.A., Edwards, D.R., Hogan, A., Sampson, M.J. and Gavrilovic, J. (2003) Metalloproteinase expression in PMA stimulated THP-1 cells: effects of peroxisome proliferator-activated receptor-y (PPARy) agonists and 9-cis-retionic acid. Journal of Biological Chemistry, 278 (51). pp. 51340-51346.

Worley, J.R., Thompkins, P.B., Lee, M.H., Hutton, M., Soloway, P., Edwards, D.R., Murphy, G. and Knauper, V. (2003) Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP). Biochemical Journal, 372. pp. 799-809.

Arlt, M., Kopitz, C., Pennington, C., Lorenz, K., Krell, H-W., Bode, W., Gansbacher, B., Khokha, R., Edwards, D.R. and Kruger, A. (2002) Increase of gelatinase-specificity of matrix metalloproteinase inhibitors correlates with anti-metastatic efficacy in a T-cell lymphoma model. Cancer Research, 62. pp. 5543-5550.

Baker, A.J., Edwards, D.R. and Murphy, G. (2002) Metalloproteinase inhibitors: Biological actions and therapeutic opportunities. Journal of Cell Science, 115. pp. 3719-3727.

Hall, M.C., Young, D.A., Rowan, A.D., Edwards, D.R. and Clark, I.M. (2002) Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors. Biotechniques, 33. pp. 1004-1008.

Jung, J.C., Leco, K.J., Edwards, D.R. and Fini, M.E. (2002) Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption. Developmental Dynamics, 223. pp. 402-413.

Koshy, P.J.T., Lundy, C.J., Rowan, A.D., Porter, S., Edwards, D.R., Hogan, A., Clark, I.M. and Cawston, T.E. (2002) The modulation of matrix metalloproteinase (MMP) and A Disintegrin And Metalloproteinase (ADAM) gene expression in human chondrocytes by interleukin-1 and oncostatin M. Arthritis and Rheumatism, 46. pp. 961-967.

Lafleur, M.A., Handsley, M., Knauper, V., Murphy, G. and Edwards, D.R. (2002) Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane type-matrix metalloproteinases (MT-MMPs). Journal of Cell Science, 115 (17). pp. 3427-3438. ISSN 0021-9533

Poghosyan, Z., Robbins, S.M., Houslay, M.D., Webster, A., Murphy, G. and Edwards, D.R. (2002) Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. Journal of Biological Chemistry, 277 (7). pp. 4999-5007. ISSN 0021-9258

Price, J.S., Waters, J.G., Darrah, C., Pennington, C., Edwards, D.R., Donell, S.T. and Clark, I.M. (2002) The role of chondrocyte senescence in osteoarthritis. Aging Cell, 1. pp. 57-65.

Qi, J.H., Ebrahem, Q., Yeow, K., Edwards, D.R., Fox, P.L. and Anand-Apte, B. (2002) Expression of sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis. Journal of Biological Chemistry, 277. pp. 13394-13400.

Radomski, A., Jurasz, P., Sanders, E.J., Overall, C.M., Edwards, D.R. and Radomski, M.W. (2002) Identification, regulation and role of Tissue Inhibitor of Metelloproteinases-4 (TIMP-4) in human platelents. British Journal of Pharmacology, 137. pp. 1330-1338.

Van Kempen, L.C.L., Rhee, J-S., Dehne, K., Lee, J., Edwards, D.R. and Coussens, L.M. (2002) Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment. Differentiation, 70. pp. 610-623.

Wall, S.J., Bevan, D., Thomas, D.W., Harding, K.G., Edwards, D.R. and Murphy, G. (2002) Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse. Journal of Investigative Dermatology, 119. pp. 91-98.

Wall, S.J. and Edwards, D.R. (2002) Quantitative reverse transcription-polymerase chain reaction (RT-PCR): A comparison of primer-dropping, competitive and real -time RT-PCRs. Analytical Biochemistry, 300. pp. 269-273.

Yeow, K.M., Kishnani, N.S., Hutton, M., Hawkes, S.P., Murphy, G. and Edwards, D.R. (2002) Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix. Matrix Biology, 21. pp. 75-88.

Young, D.A., Philllips, B.W., Lundy, C., Nutall, R.K., Hogan, A., Schultz, G.A., Leco, K.J., Clark, I.M. and Edwards, D.R. (2002) Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene. Biochemical Journal, 364. pp. 89-99.

Groft, L.L., Muzik, H., Rewcastle, N.B., Johnston, R.N., Knauper, V., Lafleur, M.A., Forsyth, P.A. and Edwards, D.R. (2001) Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas. British Journal of Cancer, 85. pp. 55-63.

Kim, H.S., Oda, T., Lopez-Guisa, J., Wing, D., Edwards, D.R., Soloway, P.D. and Eddy, A.A. (2001) TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy. Journal of the American Society of Nephrology, 12. pp. 736-748.

Lafleur, M.A., Forsyth, P.A., Atkinson, S.J., Murphy, G. and Edwards, D.R. (2001) Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activity. Biochemical and Biophysical Research Communications, 282. pp. 463-473.

Lafleur, M.A., Hollenberg, M.D., Atkinson, S.J., Knauper, V., Murphy, G. and Edwards, D.R. (2001) Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species. Biochemical Journal, 357. pp. 107-115.

Maillard, M., Cadot, B., Ball, R.Y., Sethia, K., Edwards, D.R., Perbal, B. and Tatoud, R. (2001) Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissue. Journal of Clinical Pathology, 54. pp. 275-280.

Whiteside, E.J., Jackson, M.M., Herington, A.C., Edwards, D.R. and Harvey, M.B. (2001) Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 are key regulators of extracellular matrix degradation by mouse embryos. Biology of Reproduction, 64. pp. 1331-1337.

Yong, V.W., Power, C., Forsyth, P. and Edwards, D.R. (2001) Metalloproteinases in biology and pathology of the nervous system. Nature Reviews Neuroscience, 2. pp. 502-511.

Book Section

Pennington, C.J., Nuttall, R.K., Sampieiri-Ramirez-C., Wallard, Pilgrim, S and Edwards, D.R. (2008) Quantitative real-time PCR analysis of Degradome gene expression. In: The Cancer Degradome: Proteases and Cancer Biology. Springer, pp. 49-65.

Pennington, C.J., Pilgrim, S., Span, P.N., Sweep, F.C. and Edwards, D.R. (2008) Novel Degradome markers in breast cancer. In: The Cancer Degradome: Proteases and Cancer Biology. Springer, pp. 627-643.

Monograph

Clark, I.M., Young, D.A. and Edwards, D.R. (2003) TIMP-1 enhancer sequence: real or bacterial. Letter to Editor. UNSPECIFIED.