Dr Andrew Chantry
| Job Title | Contact | Location |
|---|---|---|
| Senior Lecturer |
A dot Chantry at uea dot ac dot uk
Tel: 3551/3573 |
Biology 0.15 |
Career
- Senior Lecturer in Cell Biology, University of East Anglia (2000-present)
- Lecturer, Department of Cancer Medicine, Imperial College (1993-2000)
- Alexander von Humboldt Fellow, Max-Planck-Institute, Munich (1991-1993)
- Postdoctoral Fellow, University of Oxford (1989-1991)
- Ph.D. University of London (1989)
- B.Sc. Medical Biochemistry, University of Birmingham (1985)
Key Research Interests
Current Research Projects
- Regulation of Smad signalling by E3 ubiquitin ligases and de-ubiquitinating enzymes
- Co-operation between TGF-beta signalling, Bcr-Abl and Lyn kinase in leukaemia
- Defining a novel Pax/Smad signalling axis
- microRNAs in the TGFbeta pathway
Life in our research group
The lab is well equipped for molecular and cellular signalling analysis. This includes a self-contained tissue culture facility and high-resolution fluorescence microscope adjacent to the laboratory, gel and western blotting apparatus, benchtop centrifuges, PCR machines, and a range of incubators for bacterial cultures. We offer a productive and thriving research environment working in an internationally competitive research area relevant to disease-specific biology, and aim to make a real impact on translational studies that will lead to novel therapeutics.
PhD Positions
Please email me to discuss PhD opportunities and projects within the School of Biological Sciences.
Postdocs & Fellows
Please contact me to discuss postdoctoral funding opportunities and fellowships.Teaching Activities
- Skills for Biologists (1A4Y)
- Biomedicine (1A5Y)
- Fundamentals of Cell Biology and Biochemistry (1A14)
- Introductory Chemistry for the Life Sciences (1A61)
- Cell Biology (2B06)
- Investigation of Human Disease (2B30)
- Cellular Signalling (3C03)
- Advanced Cell Biology (3C18)
Article
Soond, SM and Chantry, A (2011) How ubiquitination regulates the TGF-β signalling pathway: New insights and new players. BioEssays, 33 (10). pp. 749-758. ISSN 02659247
Chantry, A (2011) WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targets. Cell Cycle, 10 (15). pp. 2437-2439. ISSN 1538-4101
Cutts, AJ, Soond, SM, Powell, S and Chantry, A (2011) Early phase TGFβ receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses. The International Journal of Biochemistry & Cell Biology, 43 (4). pp. 604-612. ISSN 13572725
Soond, SM and Chantry, A (2011) Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT. Oncogene, 30. pp. 2451-2462. ISSN 0950-9232
Pais, H, Nicolas, FE, Soond, S, Swingler, T, Clark, I, Chantry, A, Moulton, V and Dalmay, T (2010) Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level. RNA, 16 (3). pp. 489-494. ISSN 1355-8382
Traka, M, Gasper, AV, Melchini, A, Bacon, JR, Needs, PW, Frost, V, Chantry, A, Jones, AM, Ortori, CA, Barrett, DA, Ball, RY, Mills, RD and Mithen, RF (2008) Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate. PLoS One , 3 (7). p. 2568.
Frost, V, Grocott, T, Eccles, MR and Chantry, A (2008) Self-regulated Pax gene expression and modulation by the TGFbeta superfamily. Critical Reviews in Biochemistry and Molecular Biology, Nov-Dec, 43 (6). pp. 371-391.
Møller, GM, Frost, V, Melo, JV and Chantry, A (2007) Upregulation of the TGFbeta signalling pathway by Bcr-Abl: Implications for haemopoietic cell growth and chronic myeloid leukaemia. FEBS Letters, 581 (7). pp. 1329-1334. ISSN 0014-5793
Grocott, T, Frost, V, Maillard, M, Johansen, T, Wheeler, GN, Dawes, LJ, Wormstone, IM and Chantry, A (2007) The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. Nucleic Acids Research, 35 (3). pp. 890-901. ISSN 0305-1048
Wicks, SJ, Grocott, T, Haros, K, Maillard, M, ten Dijke, PT and Chantry, A (2006) Reversible uniquitination regulates the Smad/TGF-beta signalling pathway. Biochemical Society Transactions, 34. pp. 761-763.
Wicks, SJ, Haros, K, Maillard, M, Song, L, Cohen, RE, Dijke, PT and Chantry, A (2005) The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGFbeta signalling. Oncogene, 24 (54). pp. 8080-8084. ISSN 0950-9232
Wormstone, IM, Tamiya, S, Eldred, JA, Lazaridis, K, Chantry, A, Reddan, JR, Anderson, I and Duncan, G (2004) Characterisation of TGF-beta 2 signalling and function in a human lens cell line. Experimental Eye Research, 78 (3). pp. 705-714.
Oksvold, MP, Thien, CBF, Widerberg, J, Chantry, A, Huitfeldt, HS and Langdon, WY (2004) UV-radiation-induced internalization of the epidermal growth factor receptor requires distinct serine and tyrosine residues in the cytoplasmic carboxy-terminal domain. Radiation Research, 161 (6). pp. 685-691.
Hall, MC, Young, DA, Waters, JG, Rowan, AD, Chantry, A, Edwards, DR and Clark, IM (2003) The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. Journal of Biological Chemistry, 278 (12). pp. 10304-10313. ISSN 10304-10313
Oksvold, MP, Thien, CBF, Widerberg, J, Chantry, A, Huitfeldt, HS and Langdon, WY (2003) Serine mutations that abrogate ligand-induced uniquitination and internalization of the EGF receptor do not affect c-Cb1 association with the receptor. Oncogene, 22. pp. 8509-8518.
Sweetman, D, Smith, T, Farrell, ER, Chantry, A and Munsterberg, AM (2003) The conserved glutamine rich region of chick csal1 and csal3 mediates protein interactions with other spalt family members - implications for Townes-Brocks syndrome. Journal of Biological Chemistry, 278 (8). pp. 6560-6566. ISSN 0021-9258
Leivonen, S-K, Chantry, A, Hakkinen, L, Han, J and Kahari, V-M (2002) Smad3 mediates transforming growth factor-beta-induced collagenase-3 (MMP-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signalling pathways. Journal of Biological Chemistry, 277. pp. 46338-46346.
Abdel-Wahab, N, Wicks, SJ, Mason, RM and Chantry, A (2002) Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240. Biochemical Journal, 362 (3). pp. 643-649. ISSN 0264-6021
Monograph
Swingler, TE, Culley, KL, Nicolas, F, Soond, S, Abu-Elmagd, M, Boot-Handford, RP, Young, DA, Chantry, A, Munsterberg, A and Hajihosseini, M (2010) 066 Identification and Characterisation of Micrornas Inolved in Chondrocyte Differentiation and Osteoarthritis. Meeting Abstract. UNSPECIFIED.
Patent
2006/0276386 (2006) Use of substances inhibiting the association of smad protein with ubiquitin c-terminal hydrolase for altering cellular responses to TGF-beta or BMP. .
50573.2 (2005) Using inhibitors of Bcr-Abl kinase and TGF-beta type I receptor kinase as a dual therapy for chronic myeloid leukaemia. .
External Activities and Indicators of Esteem
- Invited speaker; British Society for Matrix Biology meeting; The Molecular Basis of Fibrosis; Imperial College of Science, Technology & Medicine, London September 18th - 19th, 2003
- Member of Editorial Board (2005-2010); Molecular and Cellular Proteomics Journal (Impact Factor 9.8)
- Invited speaker; Bioscience 2006 conference, Ubiquitin and Signalling; Glasgow July 23-27, 2006
- Invited speaker; Bioscience 2006 conference, Ubiquitin and Signalling; Glasgow July 23-27, 2006
- External examiner for six PhD students (Imperial College, Cambridge University, Newcastle University)
- Alexander von Humboldt Research Fellowship (1991-1993)
Administrative Posts/Responsibilities
- Course Director C100 Biological Sciences
- Unit Organiser for Cellular Signalling (3C03)
- Chairman of BIO Library Committee
- Member of Bioimaging Committee
- Member of Exam Board


